Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S.
The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. In human plasma, the majority of protein S circulates in a high-affinity complex with the complement regulatory protein C4b-binding protein (