Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantita

Interactions between cortical areas were studied during the search for verbal associations and reading of words. The functional anatomy and the sequence of involvement of cortical areas during the solution of these tasks have been described previously, in studies using positron emission tomography and multichannel recordings of evoked potentials combined with identification of the locations of dip

Solution of spatial and verbal tasks was studied in 43 subjects using the advanced version of the method of intracortical interaction mapping (IIM) and analysis of EEG spectra in short (250 ms) intervals. Comparison between the IIM and coherence methods during solving simple motor tasks revealed some advantages of the IIM for studying of labile cortical connections. Several stages were separated i

This paper examines how Palestinian men and women are affected by poverty related to violent conflict. By acknowledging socio-cultural understandings of gender relations, it shows how men and women become vulnerable in different ways. To counter poverty, both women and men are dependent on viable social networks. It is however clear, that females, especially those in female-headed households, have

ALS is characterized by the degeneration of upper and lower motor neurons. In about 70% of patients with ALS the disease has an spinal onset, while about 30% of the patients have a bulbar onset. Cognitive dysfunction and behavioral changes are seen in about 50% of the patients, and 15% develop frontotemporal dementia. There is no single test that provides the ALS diagnosis. The diagnosis is based

Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click

As a school nurse, it can be challenging to make values and philosophy useful in the context of a busy and stressful workday. However, values and philosophy can help guide school nurses in their profession. This article proposes strategies for how school nurses can make their school nurse’s values and philosophy visible. The first step in formulating a school nurse philosophy is to identify overal

In this work, a combination of sonication and carbon dioxide expanded liquid extraction (SA-CXLE) is used for the first time for the extraction of lipids from berry seeds. Three solvents (ethanol, methanol and ethyl lactate) are screened for the best recoveries of total lipids. Ethanol is selected due to its efficiency, greenness and sustainability. The effects of operation variables including tem

Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating a better tumor response. Initial pre-clinical studies have shown that irradiation at dose rates far exceeding those currently used in clinical con

Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during su