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Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
Tumor progression alters the composition and physical properties of the extracellular matrix. Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis. While endothelial cells are key players in cancer progression, the influence of tumor stiffness on the endothelium and the impact on metastasis is unknown. Through quantitative mass spectrometry, we find that the
A computational phase transformation model for selective laser melting processes
Selective laser melting (SLM) has gained large interest due to advanced manufacturing possibilities. However, the growing potential also necessitates reliable predictions of structures in particular regarding their long-term behaviour. The constitutive and structural response is thereby challenging to reproduce, due to the complex material behaviour. This motivates the aims of this contribution: T
Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability
Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic fluxes in ECs when cultured on a tridimens
American Judaism and the Second Vatican Council : The Response of the American Jewish Committee to Nostra Aetate
During the Second Vatican Council, American Jewish community members impacted the drafting of the declaration on the Catholic Church's attitude toward Jews and Judaism. This article explores the American Jewish Committee's reactions to the drafting and promulgation of the Declaration on the Relation of the Church with Non-Christian Religions (Nostra Aetate) and its contribution to establishing int
Have governments designed provisions for lone mothers, long-term unemployed and working poor to be multidimensional and integrated?
Monitoring, remote measurements
Specimen or core; in the laboratory (Sides available)
Installation of probes
Staphylococcal Enterotoxin C—An Update on SEC Variants, Their Structure and Properties, and Their Role in Foodborne Intoxications
Staphylococcal enterotoxins are the most common cause of foodborne intoxications (staphylococcal food poisoning) and cause a wide range of diseases. With at least six variants staphylococcal enterotoxin C (SEC) stands out as particularly diverse amongst the 25 known staphylococcal enterotoxins. Some variants present unique and even host-specific features. Here, we review the role of SEC in human a
En socioekologiskt rättvis bostadsmarknad
Housing Manifesto-22 demands for the future home are a collective result of a collaboration between CRUSH - Critical Urban Sustainability Hub, housing activists and urban researchers around Sweden.We are critically engaged in issues of sustainable urban development with a focus on the acute housing crisis. Now we want to share our thoughts on how we view the future of housing policy. Based on our
Care and Homelessness in the Shadow of Planetary Crisis
Gerillastickning : garn som politiskt vapen
Economic Freedom and Antisemitism
We examine how variation in antisemitism across countries can be explained by economic freedom. We propose two mechanisms. First, the more economic freedom, the greater the scope of market activities. If people perceive Jews as particularly skilful at doing business at the expense of others, a greater reliance on markets can increase antisemitism. Second, a key type of institution undergirding the
Does prolonged education causally affect dementia risk when adult socioeconomic status is not altered? A Swedish natural experiment in 1.3 million individuals
Intervening on modifiable risk factors to prevent dementia is of key importance, since progress-modifying treatments are not currently available. Education is inversely associated with dementia risk, but causality and mechanistic pathways remain unclear. We aimed to examine the causality of this relationship in Sweden using, as a natural experiment, data on a compulsory schooling reform that exten
Ethical issues and ethnographic work involving very young children
Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention
Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liqui
Everyday struggles and tensions in toddlers’ digital media practices
Articulation in time : Some word-initial segments in Swedish
Speech is both dynamic and distinctive at the same time. This implies a certain contradiction which has entertained researchers in phonetics and phonology for decades. The present dissertation assumes that articulation behaves as a function of time, and that we can find phonological structures in the dynamical systems. EMA is used to measure mechanical movements in Swedish speakers. The results sh
Complex sociodemographic inequalities in consultations for low back pain : lessons from multilevel intersectional analysis
Sociodemographic inequalities in the occurrence of low back pain (LBP) are well-studied. This study aimed to examine complex sociodemographic inequalities in the risk LBP consultation in the population from a socioeconomical intersectional perspective. Using register data, we identified 458,852 individuals aged 35-75 years residing in Skåne in 2013, with no previous LBP consultation since 2006. We