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Involving children in non-therapeutic research: on the development argument.

Non-therapeutic research on children raises ethical concerns. Such research is not only conducted on individuals who are incapable of providing informed consent. It also typically involves some degree of risk or discomfort, without prospects of medically benefiting the participating children. Therefore, these children seem to be instrumentalized. Some ethicists, however, have tried to sidestep thi

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

BACKGROUND: Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnormalities display profoundly different global gene expression profiles. However, it is largely unknown whether such subtype-specific leukemic signatures are unique or if they are ac

A method for evaluation of QRS shape features using a mathematical model for the ECG

Automated classification of ECG patterns is facilitated by careful selection of waveform features. This paper presents a method for evaluating the properties of features that describe the shape of a QRS complex. By examining the distances in the feature space for a class of nearly similar complexes, shape transitions which are poorly described by the feature under investigation can be readily iden

Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients: A randomized, controlled, evaluator-blind, multicentre study.

Objective. Patients with inflammatory bowel disease (IBD) often have low iron stores or anaemia. There is controversy about whether iron should be supplemented orally or intravenously (i.v.). The purpose of this study was to investigate whether treatment with intravenous iron is superior to treatment with oral iron. The primary end-points were response and remaining anaemia at the end of treatment

The relationship between reading comprehension, working memory and language in children with cochlear implants

Working memory, language, and reading comprehension are strongly associated in children with severe and profound hearing impairment treated by cochlear implants (CI). In this study we explore this relationship in sixteen Swedish children with CI. We found that over 60% of the children with CI performed at the level of their hearing peers in a reading comprehension test. Demographic factors were no

Tissue temperature control using a water-cooled applicator: Implications for transurethral laser-induced thermotherapy of benign prostatic hyperplasia

A prototype to a water-cooled applicator to be used in transurethral laser-induced thermotherapy of benign prostatic hyperplasia was developed. The flexible applicator was made of Teflon(TM) tubes except for the distal outer part which was made of glass, providing a transparent medium for laser radiation and enabling efficient cooling of the surrounding tissue. For heating, laser light from a Nd:Y

Vertical gradients and seasonal variation in stem CO2 efflux within a Norway spruce stand

Stem CO2 efflux is known to vary seasonally and vertically along tree stems. However, annual tree- and stand-scale efflux estimates are commonly based on measurements made only a few times a year, during daytime and at breast height. In this study, the effect of these simplifying assumptions on annual efflux estimates and their influence on the estimates of the importance of stems in stand-scale c

Exile Warriors : Violence and Community among Hutu Rebels in the eastern Congo

This dissertation is an anthropological study of war and violence in the volatile eastern territories of the Democratic Republic of Congo. The ethnographic focus is on one of the largest rebel groups currently operating in the Congo conflicts, the Hutu-dominated Democratic Forces for the Liberation of Rwanda (FDLR). These Hutu rebels arrived in the Congo in 1994, after the genocide in neighboring

Asymtomatic Bacteriuria as a Model to Study the Coevolution of Hosts and Bacteria.

During asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract for extended periods of time without causing symptoms of urinary tract infection. Previous studies indicate that many Escherichia coli (E. coli) strains that cause ABU have evolved from uropathogenic E. coli (UPEC) by reductive evolution and loss of the ability to express functional virulence factors. For instance, the prot

Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.

OBJECTIVES: Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential rol

Levels of 1-hydroxypyrene, symptoms and immunologic markers in vulcanization workers in the southern Sweden rubber industries.

OBJECTIVES: The aim of this study was to determine urinary 1-hydroxypyrene (1-HP) levels in contemporary Swedish vulcanization workers and in controls. These levels were used as an index substance for vulcanization fumes, as well as a biomarker for polycyclic aromatic hydrocarbons (PAHs). The risk of symptoms and changed levels of immunologic markers were investigated in relation to the 1-HP level