Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a specific loss of hypocretin-producing neurons. The incidence of NT1 increased in Sweden, Finland and Norway following Pandemrix®-vaccination, initiated to prevent the 2009 influenza pandemic. The pathogenesis of NT1 is poorly understood, and causal links to vaccination are yet to be clarified. The strong association with Human leukocy

We have developed an in-situ method using sonication (3 mm probe sonicator, 30 W, 20 kHz) and auto-reduction (control) to study the mechanism of the formation of manganese dioxide (MnO2) on a solid template (silk film), and its resulting enzymatic activity on tetramethylbenzidine (TMB) substrate. The fabrication of the silk film was first optimized for stability (no degradation) and optical transp

There is no apparent need for individuals to endure this kind of suffering in contemporary Western society with all its advantages. Nevertheless, endurance running is now a mainstream leisure pursuit. Why do hundreds of thousands of men, women and even children choose this torturous kind of leisure activity?In previous literature on consumption of extraordinary experiences, authors focus on the pu

As consumers in Western consumer culture have increasingly turned from high cultural to low cultural consumption categories to cultivate themselves, the meanings of the traditional and socio-cultural concepts used to represent different forms of consumer expertise have been blurred or altered. Drawing upon sociocultural literature on taste and distinction we attempt to provide theoretical clarity

he idea of person-centred health systems is widely advocated in political and policy declarations to better address health system challenges. A person-centred approach is advocated on political, ethical and instrumental grounds and believed to benefit service users, health professionals and the health system more broadly. However, there is continuing debate about the strategies that are available

Health care professionals frequently describe performance management and monitoring of efficiency and quality measures for external accountability as an administrative burden with limited benefits. Professionals argue that they are subject to too tight control that signals distrust, limits professional autonomy and ultimately decreases their motivation to perform. At worst, poorly incentivized ind

A central challenge in infection medicine is to determine the structure and function of host-pathogen protein-protein interactions to understand how these interactions facilitate bacterial adhesion, dissemination and survival. In this review, we focus on proteomics, electron cryo-microscopy and structural modeling to showcase instances where affinity-purification (AP) and cross-linking (XL) mass s

In this exploratory study, individuals’ processes of engagement in violent extremist groups are analysed by drawing from criminological life-course theory and narrative-based understandings of crime. Based on interviews with individuals who have participated in violent extremism, it is suggested that the process of engagement consists of three steps: (1) a weakening of informal social controls, fo

BACKGROUND: With age, the number of chronic conditions increases along with the use of medications. For several years, polypharmacy has been found to be on the increase in western societies. Polypharmacy is associated with an increased risk of adverse drug events (ADE). Medications called potentially inappropriate medications (PIM) have also been found to increase the risk of ADEs in an older popu

The change of groundwater levels after the 2016 Mw 7.0 Kumamoto crustal earthquake was evaluated using a simple conceptual hydrological model in an attempt to show the presence, intensity, and probable mechanism of water level rise observed in Kumamoto where a comprehensive observation-well network exists. A tank model was applied to verify 16 wells in the study field. In the model groundwater lev