Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably causing decreased breathing capacity and quality of life for patients. While animal models have paved the way for our understanding of pathobiology and the development of therapeutic strategies for disease management, their translational capacity is limited. There is, therefore, a well-recognised need for in

Global climate change has increasing effects on mental health and well-being (e.g., in the form of climate anxiety), both through direct exposure to its consequences (e.g., extreme weather) and through indirect exposure (i.e., the social representation or appraisal of climate change without direct contact to its physical consequences). To help people cope with distress due to climate anxiety, natu

This book explores in theory and practice how artificial intelligence (AI) intersects with and alters the city. Drawing upon a range of urban disciplines and case studies, the chapters reveal the multitude of repercussions that AI is having on urban society, urban infrastructure, urban governance, urban planning and urban sustainability.Contributors also examine how the city, far from being a pass

The Ph.D. dissertation consists of three connected, yet independent research articles, which focus on the implementation of circular economy principles in public procurement. Motivated by a curiosity for dynamics in processes of implementation I chose to investigate how actors related to processes of public procurement can implement the circular economy principles as a default. The aim of the diss

Under de senaste årtiondena har bin, såsom humlor, minskat i både antal arter och populationsmängder. Detta är ett stort problem för vårt samhälle då både jordbruket och naturliga ekosystem till stor del är beroende av dessa pollinatörer. Det är speciellt problematiskt att humlor minskar då de har förmågan att utföra en speciell sorts pollinering (buzz-pollination) som några av våra vanligaste gröThe decline of bees, such as bumblebees, over the last decades raises concerns as they are key pollinators in both agricultural and natural ecosystems. One proposed cause for the decline of wild bees is competition for food resources with managed honeybees. Detrimental effects of competition can result where co-existing species exhibit a high degree of shared resource use (i.e., niche overlap). Th

Vad är det egentligen som är så roligt? Denna fråga ställer man sig lätt när man tittar i gammal svensk skämtpress, som var en typ av tidning med en storhetstid kring sekelskiftet och första världskriget. De var roliga tidningar, men humor i historisk tid kan vara svår att förstå. För att göra detta behövs humorn sättas in i sitt sammanhang, och det är just detta jag har försökt göra. SammanhangetWhat makes something funny? This is the most basic, underlying question to this thesis, which explores the Swedish satire magazines Söndags-Nisse, Naggen and Strix on their journey through the pinnacle of the Swedish democratization process during the years 1918 to 1922. These types of magazines were of great popularity throughout all of Europe during parts of the late 19th century up until the in

Characterizing the effects of mutations on stability is critical for understanding the function and evolution of proteins and improving their biophysical properties. High throughput folding and abundance assays have been successfully used to characterize missense mutations associated with reduced stability. However, screening for increased thermodynamic stability is more challenging since such mut

BACKGROUND: Metabolic alterations contribute to disease onset and prognosis of Huntington's disease (HD). Weight loss in the R6/2 mouse model of HD is a consistent feature, with onset in mid-to-late stage of disease.OBJECTIVE: In the present study, we aimed to investigate molecular and functional changes in white adipose tissue (WAT) that occur at weight loss in R6/2 mice. We further elaborated on

The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

Demographic trends and advances in accessibility have led to more heterogeneous populations in public buildings. While providing accessible evacuation, it may be necessary to direct evacuees to different evacuation paths depending on functional capacity. The presence of people with mobility limitations (e.g., wheelchair users) may affect the evacuation of others, possibly influencing the decision

This paper treats the problem of control signal saturation caused by feedforward control from measurable load disturbances. An efficient feedforward compensator will often give significant peaks in the control signal at fast changes in the load disturbance. These peaks may cause the control signal to reach a saturation limit. In the paper, it is shown that the anti-windup function may cause unnece

Integration of fiber modification step with a modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that CMC adsorption to the cellulose model surface is prone to an