Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light–dark cycles may stimulate the development of the circadian system and

BACKGROUND: Balloon angioplasty with drug-coated balloons (DCBs) is frequently used during percutaneous coronary intervention for in-stent restenosis. Despite its frequent use, there is a lack of long-term data on the efficacy of DCB angioplasty. We conducted an investigation on the long-term efficacy outcome of in-stent restenosis, comparing DCBs, drug-eluting stents, and plain old balloon angiop

In this article, a Stein-type weighted limited information maximum likelihood (LIML) estimator is proposed. It is based on a weighted average of the ordinary least squares (OLS) and LIML estimators, with weights inversely proportional to the Hausman test statistic. The asymptotic distribution of the proposed estimator is derived by means of local-to-exogenous asymptotic theory. In addition, the as

The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of th

Valid instrumental variables (IVs) must not directly impact the outcome variable and must also be uncorrelated with nonmeasured variables. However, in practice, IVs are likely to be invalid. The existing methods can lead to large bias relative to standard errors in situations with many weak and invalid instruments. In this paper, we derive a LASSO procedure for the k-class IV estimation methods in

Offentlig-privat samverkan (”OPS”) kan ses som en typ av offentlig upphandling där en eller flera privata aktörer, genom ett gemensamt projektbolag, levererar en tjänst på uppdrag av en offentlig beställare, vanligtvis ett infrastrukturprojekt inom transport, energiförsörjning, utbildning eller sjukvård. Utmärkande för OPS är att projektbolaget ansvarar för alla delar av projektet, inklusive projePublic-private partnership ("PPP") can be seen as a type of public procurement where one or more private actors, through a joint project company, deliver a service on behalf of a public client, typically an infrastructure project in transportation, energy supply, education, or healthcare. A distinguishing feature of PPP is that the project company is responsible for all aspects of the pr

Straffinstitutet är svenska statens mest ingripande maktmedel mot sina medborgare, vars legitimitet delvis bygger på att straff anses rättvisa. Historiskt har motiven för att medvetet åsamka lidande genom straffet varierat, men en central idé har alltid varit att straff och klander motiveras av gärningspersonens förtjänst för den begångna gärningen. Denna uppsats undersöker, ur ett moralfilosofisThe institution of punishment is the Swedish state's most intrusive means of power against its citizens, with its legitimacy partly grounded in the notion that punishment is just. Historically, the motives for deliberately inflicting suffering through punishment have varied, but a central idea has always been that punishment and blame are justified by the offender's desert for their commit

Many governments worldwide have proposed transitioning from a fossil-based economy to a bioeconomy to address climate change, resource depletion, and other environmental concerns. The bioeconomy utilizes renewable biological resources across all sectors and is strongly founded on scientific advances and technological progress. Given that the bioeconomy spans multiple sectors, industries, and techn

Programme:Jörg Widmann Towards Paradise (Labyrinth VI)*Gustav Mahler Symphony No 5The trumpet concerto “Towards Paradise (Labyrinth VI)” was especially written for Håkan Hardenberger (21/22) by composer Jörg Widmann.

The Red Sea crisis and the recent attacks on commercial ships have drawn significant attention worldwide, underscoring the need to understand how such geopolitical conflicts can disrupt global supply chains and economic stability. This paper thoroughly examines the complex impacts of the crisis on India's electronics and photonics sector, recognizing the sector's crucial importance as a fundamenta

In this chapter, we explore the integration of sustainable entrepreneurship education in the context of circular entrepreneurship ecosystems, highlighting the necessity of shifting from traditional profit-centric models towards ones that emphasise sustainability and circular economy principles. We critique current educational practices for overlooking environmental and ethical considerations and a

The lawsuit filed in Shanxi by the families of 18 women forced into sexual slavery by the imperial Japanese army is the first such challenge in a Chinese court.It marks a critical moment in the movement, but success will depend on domestic and international support.

Positioning Polymer Electrolyte Fuel Cells (PEFCs) in the market depends on substantial advances that start from a deep knowledge concerning the influence of operating parameters, such as temperature-sweep and high-current density. In the present study, a comprehensive analysis of the impedance behavior of a single PEFC via Electrochemical Impedance Spectroscopy (EIS) was carried out in order to u

α-synuclein is a neuronal protein implicated in neurotransmitter release. Its function is thought to critically depend on the dynamic equilibrium between its free and its membrane-bound state. α-synuclein amyloid formation, implicated in Parkinson's disease, is also modulated by lipid membranes. The interplay between these processes remains elusive yet relates to the outstanding question of what d

OBJECTIVES: Analysis of the long-term risks of ischaemic stroke and cerebral bleeding in patients with atrial fibrillation after mitral valve surgery and concomitant Cox-maze IV procedure. METHODS: In total, 397 patients with symptomatic degenerative mitral valve insuffciency and atrial fibrillation, underwent mitral valve surgery and Cox-maze IV in Sweden between 2009 and 2017. In this retrospect