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Security at what cost? Dual-use research oversight and its effect on innovation: an empirical investigation of the Danish Biosecurity Act

Technological innovation has been a crucial driver of economic growth, leading to significant improvements in our quality of life. However, the rise of dual-use technologies—those with both beneficial and harmful potential—poses increasing risks. This paper examines what the impact of government policies designed to mitigate these risks is on innovation, focusing on Denmark’s 2008 Biosecurity Law

Where are the female science professors? : A personal perspective

The first woman to earn a Professorship at a University in Europe was Laura Maria Caterina Bassi, who earned a professorship in physics at the University of Bologna in 1732. Almost 300 years and three waves of feminism later, in 2016, women typically still only comprise 20% (or less) of the number of full professors in Europe. This opinion article will discuss the experiences of being a female aca

Enzyme Architecture : Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to d-glyceraldehyde phosphate (GAP), via general base catalysis by E165. Historically, this enzyme has been an extremely important model system for understanding the fundamentals of biological catalysis. TIM is activated through an energetically demanding conformational cha

Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes : The Case of Serum Paraoxonase 1

Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Structurally, PON1 is a six-bladed β-propeller with a flexible loop (residues 70-81) covering the active site. This loop contains a functionally critical Tyr at position 71. We have performed detailed experimental and computational a

40 Festival Internacional de Música de Canarias with Sinfónica de Tenerife

Håkan Hardenberger, conductor Orquesta Sinfónica de Tenerife, Ensemble Wind- and percussionworks included: Aaron Copland: Fanfare for the Common Man (1942) Irene Raquel Fariña: PhidiasErnst Krenek: Kleine Blasmusik, op. 70a IntervalEinojuhani Rautavaara: A Requiem in Our Time (1953)Antonin Dvořák: Serenade für Bläserensemble d-Moll op. 44

Balancing State Sovereignty and Climate Change as a Common Concern of Humankind

Climate change constitutes a major collective action problem because it affects all of humanity, and an effective response to it is unlikely if individual actors prioritize their own interests independently. The international community has thus acknowledged that the issue requires a collective response. Climate change has also been considered a common concern of humankind. The concept of common co

Det digitala övervakningssamhället: Ett nödvändigt ont? - En analys av förenligheten mellan EU-kommissionens förslag till CSAM-förordning och grundläggande fri- och rättigheter

Digitaliseringen har inte bara revolutionerat vår vardag och hur vi kommunicerar utan även skapat en ny arena för brottslighet. Bland de mest bekymmersamma brotten som har ökat i takt med den digitala utvecklingen är sexuella övergrepp mot barn. I syfte bekämpa och förebygga dessa brott presenterade EU-kommissionen 2022 ett förslag till en förordning som ålägger leverantörer av interpersonella komDigitalization has not only revolutionized our daily lives and how we communicate but has also created a new arena for criminal activity. Among the most concerning crimes that have increased with the rise of digital development is child sexual abuse. In order to combat and prevent these crimes, the European Commission presented a proposal for a regulation in 2022 that obliges providers of interper

Tenacious Documents : Exploring the Allure of Documentation in Swedish Compulsory Schools

De svenska utbildningsmyndigheterna står inför ett seglivat problem. Lärare har under många år uttryckt missnöje över alltmer utbredda och genomgripande krav på dokumentation. En hel del dokumentation stjäl tid som annars skulle kunna läggas på elevers lärande och att utveckla undervisningen, lyder klagomålen. Under de senaste 15 åren har olika svenska regeringar försökt åtgärda detta problem, menThe Swedish education authorities are up against a tenacious problem. Teachers have for years expressed dissatisfaction over increasingly prolific and pervasive demands for documentation that hijacks time that could have been invested in pupils’ learning. Over the past 15 years different Swedish governments have sought to remedy this problem but to no avail. The ‘burden of documentation’, as it is

People Detection and Occupancy Estimation Using Ultrasound Signals

Fladdermöss lever stora delar av sina liv i mörker och använder sig därför av ultraljudssignaler, istället för ljus, för att navigera och jaga. Om vi låter oss inspireras av fladdermössens navigeringsteknik, kan vi då också lära oss att upptäcka personer i ett rum med hjälp av ultraljud? Svaret på frågan är ja, det är möjligt att upptäcka mänsklig närvaro i ett rum genom att använda ultraljud. SjFinding a non-intrusive way of detecting human presence and counting the number of people in a room poses a challenging problem. This thesis presents a solution to said problem, utilizing ultrasound signals. Analysis of the echo and reverberation of ultrasound signals provides acoustic information about the surrounding environment, which is altered by potential occupants. By employing such a techn

Exercise cardiovascular magnetic resonance shows improved diastolic filling by atrioventricular area difference in athletes and controls

Hydraulic force, a novel mechanism shown to aid diastolic filling, can be calculated by assessing the geometrical relationship between the left ventricular and atrial short-axis areas (atrioventricular area difference, AVAD) (Maksuti E, Carlsson M, Arheden H, Kovács SJ, Broome M, Ugander M. Sci Rep 7: 43505-43510, 2017; Steding-Ehrenborg K, Hedstrom € E, Carlsson M, Maksuti E, Broome M, Ugander M,

Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection : The implication of occult seeds after initial surgery

Objective Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathologica

Distinguishability-induced many-body decoherence

We show that many-body interference phenomena are exponentially suppressed in the particle number, if the identical quantum objects brought to interference acquire a finite level of distinguishability through statistical mixing of some internal, unobserved degrees of freedom. We discuss consequences for cold atom and photonic circuitry experiments.

Boron-induced transformation of ultrathin Au films into two-dimensional metallic nanostructures

The synthesis of large, freestanding, single-atom-thick two-dimensional (2D) metallic materials remains challenging due to the isotropic nature of metallic bonding. Here, we present a bottom-up approach for fabricating macroscopically large, nearly freestanding 2D gold (Au) monolayers, consisting of nanostructured patches. By forming Au monolayers on an Ir(111) substrate and embedding boron (B) at

Aggregation of cardiovascular risk factors in a cohort of 40-year-olds participating in a population-based health screening program in Sweden

Background: It is important to identify and evaluate cardiovascular risk factors at an early stage to address them accordingly. Among the younger population, the metabolic syndrome is less common than in older ages. However, each separate metabolic risk factor still has an additive effect on cardiovascular risk factor burden. Non-metabolic risk factors that occur in the younger population include

Europeisk förvaltningsrätt i Sverige, 2 uppl.

Det förvaltningsrättsliga landskapet i Sverige har under de senaste decennierna blivit allt mer sammanlänkat med Europarätten, dvs. EU-rätten, Europakonventionen samt annat material från Europarådet. För att som svensk jurist kunna arbeta med förvaltningsrättsliga frågor är det nödvändigt att ha en grundläggande förståelse för hur Europarätten påverkar de svenska rättsliga strukturerna. I verket p