This issue of Journal of Scandinavian Cinema features a diverse range of articles covering topics from early silent cinema to contemporary genre filmmaking. Highlights include discussions of digital restoration, cinematic influence, Sámi culture, horror in children’s cinema and film literacy. The issue also reviews new research on Carl Th. Dreyer that emphasizes the emotional aspects of his films.

Background: Pediatric atopic dermatitis (AD) is a common chronic disease. For assessing treatment outcomes, the concept of controlled and uncontrolled AD has been introduced. Objectives: The aim of the study was to estimate healthcare resource use in terms of visits, treatments and costs in children with controlled and uncontrolled AD. Materials & Methods: The study utilised administrative dat

Phosphate hydrolysis is ubiquitous in biology. However, despite intensive research on this class of reactions, the precise nature of the reaction mechanism remains controversial. Herein, we have examined the hydrolysis of three homologous phosphate diesters. The solvation free energy was simulated by means of either an implicit solvation model (COSMO), hybrid quantum mechanical/molecular mechanica

The idea that enzymes catalyze reactions by dynamical coupling between the conformational motions and the chemical coordinates has recently attracted major experimental and theoretical interest. However, experimental studies have not directly established that the conformational motions transfer energy to the chemical coordinate, and simulating enzyme catalysis on the relevant timescales has been i

DNA polymerases make up a family of enzymes responsible for regulating DNA replication and repair, which in turn maintains the integrity of the genome. However, despite intensive kinetic, crystallographic, and computational studies, elucidation of the detailed enzymatic mechanism still presents a significant challenge. We recently developed an alternative strategy for exploring the fidelity and me

Phosphate monoester and anhydride hydrolysis is ubiquitous in biology, being involved in, amongst other things, signal transduction, energy production, and the regulation of protein function. Therefore, this reaction has understandably been the focus of intensive research. Nevertheless, the precise mechanism by which phosphate monoester hydrolysis proceeds remains controversial. Traditionally, it

Many phosphatases make use of metal ions to aid catalysis of phosphate ester hydrolysis. Here, we investigate the impact of metal ions on the potential energy surface (PES), and hence the preferred reaction mechanism, for a simple model for hydrolysis of phosphate ester monoanions. We show that, while both associative (A(N) + D(N)) and dissociative (D(N) + A(N)) mechanisms are represented on the p

This entry reflects on the meaning and significance of playful work in contemporary organizations. In recent years, playful work has become a prominent managerial technique to combat employee disengagement and low morale in organizations. This trend has its roots in positive psychology, especially Csikszentmihalyi’s concept of flow and Deci and Ryan’s self-determination theory. Developments such a

The hydrolysis of phosphate esters is crucially important to biological systems, being involved in, among other things, signaling, energy transduction, biosynthesis, and the regulation of protein function. Despite this, there are many questions that remain unanswered in this important field, particularly with regard to the preferred mechanism of hydrolysis of phosphate esters, which can proceed th

Hybrid quantum mechanical/molecular mechanical (QM/MM) approaches have been used to provide a general scheme for chemical reactions in proteins. However, such approaches still present a major challenge to computational chemists, not only because of the need for very large computer time in order to evaluate the QM energy but also because of the need for proper computational sampling. This review fo

Phosphate ester hydrolysis is ubiquitous in biology, playing a central role in energy production, signaling, biosynthesis, and the regulation of protein function among other things. Although the mechanism of action of the enzymes regulating this reaction has been the focus of intensive research in the past few decades, the correct description of this apparently simple reaction remains controversia

Advancements in AI and Robotics have made it possible, at least to some extent, for technology to interact with humans in humanlike ways, such as being able to use natural language. Some of these technologies have rapidly overtaken the consumer market in the form of services such as ChatGPT, which in 2022 became the fastest growing user-base in history by acquiring 100 million users within two mon

What future aspirations have informed the incentives for producing children's literature in Muslim minority communities? What social dynamics and theological debates have accompanied its visions of Islamic futures? What narrative tropes, visual-aesthetics norms and literary genres has it appropriated, while maturing into an innovative religious-pedagogic-literary expression? Probing such questions

Protein tyrosine phosphatase 1B (PTP1B) is an important drug target for the treatment of type II diabetes and obesity. There are strong indications that a novel class of allosteric inhibitors act by preventing the closure of the WPD-loop [C. Wiesmann, K.J. Barr, J. Kung, J. Zhu, D.A. Erlanson, W. Shen, B.J. Fahr, M. Zhong, L. Taylor, M. Randall, R.S. McDowell, S.K. Hansen, Allosteric inhibition of

Targeted molecular dynamics was used to examine the mechanism of WPD loop closure in PTP1B, which is essential for the activity of the enzyme. Two important regions are identified: the R-loop (residues 113-118), which assists in substrate binding, and the S-loop (residues 198-209), which undergoes a conformational change that appears to be vital for the movement of the WPD loop. The S-loop is adja

Microstrip patch antennas have become essential in modern communication systems due to their compact size and ease of fabrication. However, their performance is often constrained by narrow bandwidth, low radiation efficiency, and low gain, especially in miniaturized designs. The performance limits of microstrip patch antennas are helpful in understanding and overcoming these challenges. These perf

Intracellular delivery is crucial in biological and medical studies. Although many molecular tools have been created for cell-based gene therapies, it remains challenging to introduce external molecules into cells. As one of the most popular non-viral transfection methods, electroporation induces transient pores in the cell membrane by applying an external electric field. Unsatisfactory transfecti

Quark spin effects in e+e- annihilation to pseudoscalar and vector mesons are implemented for the first time in the pythia Monte Carlo event generator. The spin-dependent fragmentation of the string stretched between the produced quark-antiquark pair with correlated spin states is described by the string+P30 model implemented in the string fragmentation routine of pythia by using the StringSpinner