Background: Much is unknown regarding the regulation of amyloid precursor protein (APP) processing in the human central nervous system. It has been hypothesized that amyloidogenic APP-processing preferentially occurs in the regulated secretory pathway of neurons. To test this hypothesis we looked for correlations of APP-derived molecules in CSF with chromogranin (Cg) derived peptides, representing

Providing equal access to health care is an important objective in most health care systems. It is especially pertinent in systems like the Swedish primary care market, where providers are free to establish themselves in any part of the country. To improve equity in access to care, 15 out 21 county councils in Sweden have implemented risk-adjusted capitation based on the Care Need Index, which inc

The Long-tailed Duck Clangula hyemalis is the main offshore wintering seaduckspecies in the Baltic region, although numbers have declined steeply since the early 1990s. The reasons for the decline are not well understood and information about habitat choice is scarce. Blue Mussels Mytilus edulis are the main food source for Longtailed Ducks in the southern Baltic Sea and here we have used both mod

The occurrence of wintering and spring-staging sea ducksin the southern part of Swedish Öresund was surveyedfrom air and ship during the period 2001–2011. Altogether22 air and 20 boat surveys were made during themonths November–May and here we present the resultsregarding five commonly recorded sea ducks. We presentthe numbers recorded and the general time pattern of occurrenceduring winter and sp

Neck-banding of Greylag Geese in the Nordic countries was initiated in 1984 bythe Nordic Council for Wildlife Research as there was a need for a thorough knowledge of various aspects of the population ecology and migration patterns of the populations in different parts of the four countries. Since the start in 1984 more than 6400 Greylag Geese have been neck-banded, yielding more than 250,000 read

Co-occurrence of closely related species can cause behavioral interference in mating and increase hybridization risk. Theoretically, this could lead to the evolution of more species-specific mate preferences and sexual signaling traits. Alternatively, females can learn to reject heterospecific males, to avoid male sexual interference from closely related species. Such learned mate discrimination c

An isolated, yet virtually intact contour feather(FUM-1980) from the lower Eocene Fur Formation of Denmarkwas analysed using multiple imaging and moleculartechniques, including field emission gun scanning electronmicroscopy (FEG-SEM), X-ray absorption spectroscopy andtime-of-flight secondary ion mass spectrometry (ToF-SIMS).Additionally, synchrotron radiation X-ray tomographicmicroscopy (SRXTM) waAn isolated, yet virtually intact contour feather (FUM-1980) from the lower Eocene Fur Formation of Denmark was analysed using multiple imaging and molecular techniques, including field emission gun scanning electron microscopy (FEG-SEM), X-ray absorption spectroscopy and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Additionally, synchrotron radiation X-ray tomographic microscopy (SR

Purpose – Supply chains evolve and change in size, shape and configuration, and in how they are coordinated, controlled and managed. Some supply chains are mature and relatively unchanging. Some are subject to significant change. New supply chains may emerge and evolve for a variety of reasons.The purpose of this paper is to examine the nature of supply chain evolution and address the question “Wh

The IEEE 1687 standard describes reconfigurable structures allowing to flexibly access the instruments existing within devices (e.g., to support test, debug, calibration, etc.), by the use of configurable modules acting as controllable switches. The increasing adoption of this standard requires the availability of algorithms and tools to automate its usage. Since the resulting networks could inevi

Bean Geese Anser fabalis have been neck-banded extensivelyin the breeding areas in northern Finland duringtwo periods: 1978–1994 and 2002–2009. The observationsof these geese showed marked differences in timingof migration and location of wintering and stagingareas between the two periods. The Bean Geese stayedfurther to the north in south Sweden during the autumnin the latter period and arrived l

Groundwater samples were collected from several soil depths down to 50 m below soil surface to investigate vertical profiles of NO3 − and hydrogeochemical characteristics of the experimental site. The experimental site is located in the Shimabara City, Nagasaki, Japan, where nitrate contamination in groundwater is severe due to intensive agricultural production. A transition zone regarding dissolv

We report on the opportunities for direct geometry chopper spectrometers (DGCS) by polychromatic illumination of the sample. At pulsed sources the use of multiple initial neutron energies appears naturally, if the repetition rate of chopper in front of the sample is larger than the repetition rate of the source. As a consequence, a large part of the spectrum is measured redundantly with variable e