We investigated the efficacy of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes for 4 years in clinical practice.

Hot desert ecosystems are characterized by high soil temperatures with large fluctuations annually and diurnally. Thus, one could hypothesize that not only the microbial community would be adapted to high temperatures, but also have a large temperature range conducive for growth. We determined the temperature sensitivity of the soil bacterial community from the Chihuahuan Desert, Big Bend National

The role of infection in rheumatoid arthritis (RA) has not been determined. We aimed to document the infectious burden and some aspects of antibacterial immunity in a large and prospective cohort study of RA patients in the early and late stages of the disease and in their relatives predisposed to RA.

Surface electron dynamics unfold at time and length scales down to attoseconds and nanometres, making direct imaging with extreme spatiotemporal resolution highly desirable. However, this has turned out to be a major challenge even with the advent of reliable attosecond light sources. In this paper, photoelectrons from Ag nanowires and nanoparticles excited by extreme ultraviolet (XUV) attosecond

The complex network of neuronal cells in the retina makes it a potential target of neuronal toxicity - a risk factor for visual loss. With growing use of nanoparticles (NPs) in commercial and medical applications, including ophthalmology, there is a need for reliable models for early prediction of NP toxicity in the eye and retina. Metal NPs, such as gold and silver, gain much of attention in the

Patients with some autoimmune diseases (AIDs) are at increased risk of cancer, possibly a result of an underlying dysregulation of the immune system, medication, treatment or, probably, surveillance bias. Data on cancer mortality and survival in patients previously diagnosed with AIDs would provide novel information on these comorbidities and their clinical implications. Standardized mortality rat

The open and closed forms of ozone and the path connecting them through a transition state, in C-2v symmetry, are explored using the multi-state, multi-configurational second order perturbative method, MS-CASPT2. It is demonstrated that, by using an ANO-L triple-zeta basis set, it is possible to set up an active space able to describe the otherwise troublesome transition state region. Both a conic

We present a Monte Carlo study of dijet angular distributions at root s = 14 TeV. First we perform a next-to- leading order QCD study; we calculate the distributions in four different bins of dijet invariant mass using different Monte Carlo programs and different jet algorithms, and we also investigate the systematic uncertainties coming from the choice of the parton distribution functions and the

Currently, there is increasing competition for waste as feedstock for the growing number of biogas plants. This has led to fluctuation in feedstock supply and biogas plants being operated below maximum capacity. The feasibility of supplementing a protein/lipid-rich industrial waste (pig manure, slaughterhouse waste, food processing and poultry waste) mesophilic anaerobic digester with carbohydrate

The integrated dynamic ecosystem model ForSAFE-VEG was used to estimate critical loads for nitrogen using different chemical and biological criteria, and attempting to account for possible effects of climate change. The study is based on a model application on sites used for critical loads assessments in Sweden and France, focusing on the ecological effect of nitrogen pollution. To assess critical

Abstract The nutrient and carbon (C) allocation dynamics in mycorrhizal hyphal networks cause variation in costs and benefits for individual plants and fungi and influence the productivity, diversity and C cycling in ecosystems. We manipulated light and phosphorus (P) availability in a pot experiment with Trifolium subterraneum colonised by the arbuscular mycorrhizal (AM) fungus Glomus intraradice