Background: Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multifactorial etiology including hypertension and altered hemodynamics and disruption of vessel integrity. Patients with autoimmune disease and certain immune modulator therapies are a

Observations from orbital spacecraft have shown that Jezero crater on Mars contains a prominent fan-shaped body of sedimentary rock deposited at its western margin. The Perseverance rover landed in Jezero crater in February 2021. We analyze images taken by the rover in the 3 months after landing. The fan has outcrop faces, which were invisible from orbit, that record the hydrological evolution of

Objectives: Accurate and reliable diagnostics are crucial as histopathological type influ-ences selection of treatment in lung cancer. The aim of this study was to evaluate real-world accuracy and use of immunohistochemical (IHC) staining in lung cancer diagnostics. Materials and Methods: The diagnosis and used IHC stains for small specimens with lung cancer on follow-up resection were retrospecti

This study presents a spatial analysis of two regions in southern Iberia (Western Sierra Morena and Lands of Antequera) as a means to deepen our understanding of the Romanisation of the province Ulterior Baetica. Its theoretical foundations rely on the belief that human communities modify and adapt to their surroundings according to their changing needs (functional and symbolic, amongst many other

Covalent-functionalized graphene nanoplatelets (CF-GNPs) inside a circular heated-pipe and the subsequent pressure decrease loss within a fully developed turbulent flow were discussed in this research. Four samples of nanofluids were prepared and investigated in the ranges of 0.025 wt.%, 0.05 wt.%, 0.075 wt.%, and 0.1 wt.%. Different tools such as field emission scanning electron microscopy (FE-SE

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated si

The Iberian Peninsula has been repeatedly characterised by its wide diversity of landscapes and of communities inhabiting them in Antiquity. This circumstance has hindered the possibility of developing holistic interpretations of cultural change experienced by these communities. However, recent research (e.g. Moreno Escobar, Ojeda Rivera and García Sanjuán 2020) has highlighted how the analysis of

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their

Ips sexdentatus (Coleoptera: Curculionidae: Scolytinae) is one of the most destructive and economically important forest pests. A better understanding of molecular mechanisms underlying its adaptation to toxic host compounds may unleash the potential for future management of this pest. Gene expression studies could be considered as one of the key experimental approaches for such purposes. A suitab

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout different areas of the central nervous system (CNS) in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Deposition of neurofibrillary tangles (NFTs) in specific CNS regions correlates with the severity o

Background Cutaneous leishmaniasis (CL) is frequent in travellers and can involve oro-nasal mucosae. Clinical presentation impacts therapeutic management. Methodology Demographic and clinical data from 459 travellers infected in 47 different countries were collected by members of the European LeishMan consortium. The infecting Leishmania species was identified in 198 patients. Principal findings C

The São Francisco River Basin (SFRB) is one of the main watersheds in Brazil, standing out for generating energy and consumption, among other ecosystem services. Hence, it is important to identify hydrological drought events and the anomalous climate patterns associated with dry conditions. The Standard Precipitation Index (SPI) for 12 months was used to identify hydrological drought episodes over

Large-scale historical databases featuring individual-level causes of death offer the potential for longitudinal studies of health and illnesses. There is, however, a risk that the transformation of the primary sources into ‘data’ may strip them of the very qualities required for proper medical historical analysis. Based on a pilot study of all 11,100 deaths registered in Copenhagen in 1880–1881,

This chapter discusses the value of a capability approach in historical research on older people. Historians are generally focused on studying continuity and change over time. Their research often aims at explaining how and why certain phenomena appear and take different shapes. Capability is a way of capturing an individual’s ability to live a meaningful life, or a life that they perceive as good

Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the interconversion of glyceraldehyde 3-phosphate and dihydroxy-acetone phosphate. This simple reaction involves the shuttling of protons mediated by protolysable side chains. The catalytic power of TIM is thought to stem from its ability to facilitate the deprotonation of a carbon next to a carbonyl group to generate an