Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary EC

PREMIERE: Premiered by Hu Liu during the 2017 China-ASEAN Music Week at the Guangxi University of the Arts on May 28th.NOTE:Imitating the Vivacity of the Human Voice, is a meditation on diversity and the roiling of coexistence. In this piece disparate components from east and west do not suggest a transcendent unification. Rather, rhetorical devices such as “Tiaogong” [跳弓] or “Schleifer” become so

Lingua-Palatal #2, has been totally recomposed in 2020, and is written for four voices that use close amplification to heighten the resonant differences between the oral and nasal cavities. This should be a very strong effect, as if the listener is actually inside the cavity. Therefore, special care must be given to the microphone type and placement. It might even be possible to put microphones in

BACKGROUND: There is no consensus on best content, set-up, category of involved healthcare professionals or duration of rehabilitation-programs for patients with chronic musculoskeletal pain, and outcomes show varying results. Individual care regimes for sub-groups of patients have been proposed.AIM: To describe the type of interventions used in a physiotherapist-led, rehabilitation-program for pa

The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of caro

In this thesis degradation of chlorinated solvents, e.g., tetrachloroethene (perchloroethylene [PCE]), has been examined, both natural occurring degradation and in situ remediation strategies. The projects included have focused on two field sites of former dry-cleaning facilities, which are contaminated with PCE in both the groundwater and the sediments. One site had only been exposed to natural d

This thesis is about the development of adjective use and meaning structures examined from a cognitive linguistic perspective. Adjectives modify nominal meanings and it is in context, in the interaction with the noun that the adjective meaning and configuration is determined. Nearly 13,000 adjective-noun combinations from texts written by Swedish students in grades 3, 5, 9, and 11/12 were analysed

Objectives: Simple decompression is an accepted surgical treatment of ulnar nerve entrapment at the elbow (UNE). Our purpose was to evaluate the outcome and potential predictors for the outcome after simple decompression in UNE.Methods: All surgically treated UNE cases (from 2004-2008) at our department were studied retrospectively. Out of 285 primary surgeries, 242 primary simple ulnar nerve deco

Objectives: Knowledge is scarce about the outcome of revision surgery for recurrent or persistent ulnar nerve entrapmentat the elbow (UNE). We studied the outcome of subcutaneous (SCT) and submuscular (SMT) ulnar nerve transpositionsdue to UNE, analyzing both primary and revision surgeries, aiming to identify predictors for revision surgery.Methods: All surgically treated UNE cases (2004-2008) at

A central challenge for sustainable development is how societies are to avoid, minimize or address impacts from anthropogenic climate change. However, competing perspectives on “what should be sustained” lead to widely different understandings of what mitigation, adaptation and loss and damage entail and how best to approach them. We provide a novel conceptual and empirical comparison of two contr

Residual stress can be introduced unintentionally into the workpiece with various magnitudes and distributions through all manufacturing processes. These stresses have a significant effect upon the performance of the final component. Understanding the residual stress imparted by machining is an essential aspect of understanding the machining process and overall part quality. Although many investig

Thermochromic leuco dyes may be applied to textiles substrates to provide colour change when the temperature is raised. These materials have been used previously by designers in interesting ways, activated with a variety of heat sources. This paper presents the outcome of research developing a set of ‘design variables’ appropriate for textile designers, for use with thermochromic textiles when act

Rank and cardinality penalties are hard to handle in optimization frameworks due to non-convexity and discontinuity. Strong approximations have been a subject of intense study and numerous formulations have been proposed. Most of these can be described as separable, meaning that they apply a penalty to each element (or singular value) based on size, without considering the joint distribution. In t

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The motor and non-motor symptoms of PD lead to a number of consequences in everyday life for persons with PD (PwPD). PwPD continuously need to adapt to their new life situation and despite medical treatment, the impact of PD on everyday life is inevitable and can lead to a lower level of life satisfaction (LS). LS is a