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Asthma and COPID: differences and similarities - With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort (R)) in both diseases

Asthma and chronic obstructive pulmonary disease (COPD) both have a high prevalence worldwide and yet each condition remains underdiagnosed. Despite a number of common features, these inflammatory respiratory syndromes have distinct clinical outcomes. COPD represents a greater economic burden than asthma because it has a less favourable prognosis and is associated with greater morbidity and mortal

dUTPase from the retrovirus equine infectious anemia virus: specificity, turnover and inhibition

The kinetic properties of dUTPase from equine infectious anemia virus (EIAV) were investigated. KM (1.1 [plusmn] 0.1 [mu ]M) and kcat (25 s[minus ]1) were found to be independent of pH in the neutral pH range. Above pH 8.0, KM increases slightly. Below pH 6.0, the enzyme is rapidly deactivated. Detergent was found to enhance activity, leaving KM and kcat unaffected. Compared to the Escherichia col

Ecosystem service supply and vulnerability to global change in Europe

Global change will alter the supply of ecosystem services that are vital for human well-being. To investigate ecosystem service supply during the 21st century, we used a range of ecosystem models and scenarios of climate and land-use change to conduct a Europe-wide assessment. Large changes in climate and land use typically resulted in large changes in ecosystem service supply. Some of these trend

Development of Detector Systems for Internal and Fixed Target Heavy Ion Physics Experiments

This thesis deals with intermediate energy heavy ion reactions with the particular aim to study the nuclear matter equation of state which defines the relation between statistical parameters of a fermionic system. The development of equipment for two experiments, CA47 at The Svedberg Laboratory in Uppsala, Sweden and R16 at Kernfysisch Versneller Instituut (KVI), Groningen, The Netherlands, are d

New structural chromosomal rearrangements in congenital leukemia

The karyotypic abnormalities and clinical data on three patients in whom acute leukemia was diagnosed within the first 6 months of life are presented. The four structural chromosomal rearrangements detected in the bone marrow from these patients, i.e., t(7;12)(q36;p13) and t(1;19)(q11;q11) in case 1, t(2;10;11;12)(q21q31;p13;q13;q24) in case 2, and t(11;19)(q23;p13) in case 3, have not previously

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting

Background strain is known to influence the way a genetic manipulation affects mouse phenotypes. Despite data that demonstrate variations in the primary phenotype of basic inbred strains of mice, there is limited data available about specific metabolic fluxes in vivo that may be responsible for the differences in strain phenotypes. In this study, a simple stable isotope tracer/NMR spectroscopic pr

A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dosed of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients

Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients. The aim of this study was to compare the anti-emetic efficacy and safety of ondansetron, placebo and metoclopramide in the treatment of opioid-induced nausea and emesis (OIE) in cancer patients. This was a multinational, multicentre, double-blind, parallel group study in which cancer patients

Lönande lärande - teknologisk förändring, yrkesskicklighet och lön i svensk verkstadsindustri omrking 1900

Popular Abstract in Swedish Av de industrier som kom att spela en viktig roll för den starka ekonomiska utvecklingen i Sverige från 1890-talet och framåt befann sig den moderna verkstadsindustrin i frontlinjen. Syftet med denna avhandling är att diskutera hur de teknologiska förändringar som präglade den andra industriella revolutionens inledande fas påverkade den relativa efterfrågan på yrkesskicSweden experienced a remarkable economic growth in the period 1890-1930, to a large extent due to a very successful adaptation of core elements of the Second Industrial Revolution such as electricity and mechanical engineering. Theoretically this thesis aims at discussing changes in the balance between the relative demand for skilled and unskilled labour during the first phase of the Second Indust

The impact of metabolic and blood pressure control on incidence and progression of nephropathy. A 10-year study of 385 type 2 diabetic patients

The aim of the present study was to find clinical parameters affecting incidence and progression of nephropathy in type 2 diabetic patients. A prospective study for 10 years was performed in 385 type 2 diabetic patients (diabetes diagnosis > or =30 years) attending a hospital-based outpatient clinic. Medical risk indicators like diabetes duration, HbA(1c), and blood pressure were related to the de

Asian Models of Agricultural Development and their Relevance to Afrika

This working paper discusses the different Asian experiences of the Green Revolution from the late 1960s to the 1980s in the perspective of earlier developments of agricultural intensification. The intention of the paper is to identify common features and conditions contributing to the considerable success of Asian agriculture over the past 30 years. The authors argue that the Green Revolution mus

A fishy mosasaur: the axial skeleton of Plotosaurus (Reptilia, Squamata) reassessed

The concept of convergence, that is, how unrelated animals independently evolve similar morphological traits, is a fundamental aspect of evolution. Hitherto, the Mesozoic ichthyosaurs were regarded as the sole obligate marine reptiles that achieved a fully streamlined body and a semilunate tail fluke. However, analyses of vertebral centrum morphometrics and process orientation have revealed that a

Satiation effects in piscivore prey size selection

We present a functional response model that primarily evaluates effects of satiation in piscivore prey-size selection. The model also includes other passive processes, such as prey-size-dependent encounter rate and prey-size-dependent capture success, where capture success decreases and encounter rate increases with prey size. The model generates a wide variety of outcomes, where small, intermedia