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Voltage-gated Ca2+ (CaV) channel dysfunction leads to impaired glucose-stimulated insulin secretion in pancreatic β-cells and contributes to the development of type-2 diabetes (T2D). The role of the low-voltage gated T-type CaV channels in β-cells remains obscure. Here we have measured the global expression of T-type CaV3.2 channels in human islets and found that gene expression of CACNA1H, encodi
This article examines how Singaporean parents negotiate complex expectations in relation to current reforms aimed at raising creative and problem-solving children. Based on ethnographic fieldwork, the article explores how ideas of brain-claiming, resilience, and natural exposure shape parenting practices around young children’s learning. The findings suggest that parents’ sentiments of uncertaintyThis article examines how Singaporean parents negotiate complex expectations in relation to current reforms aimed at raising creative and problem-solving children. Based on ethnographic fieldwork, the article explores how ideas of brain-claiming, resilience, and natural exposure shape parenting practices around young children’s learning. The findings suggest that parents’ sentiments of uncertainty
Background: Several objective gait parameters are associated with cognitive impairment, but there is limitedknowledge of gait models in people with mild cognitive impairment (MCI).Research question: How can 18 objective gait characteristics be used to define different components of gait inpeople with MCI (with suspected incipient neurocognitive disorder) and cognitively unimpaired people (CU),resp
I Sveriges grundskolor använder musiklärare en stor del av sin arbetstid till arbete som rör bedömning och betygsättning. Fem musiklärare har i denna studie intervjuats med syftet att ta reda på hur de konstruerar sina bedömnings- och betygsättningspraktiker genom att undersöka vilka omständigheter som inverkar på dessa. Studiens vetenskapsteoretiska förankring finns i socialkonstruktionismen; teaMusic teachers in Swedish compulsory schools spend much of their time with work concerning assessment and grading. In this study, five music teachers have been interviewed with the purpose of finding out how they construct their assessment and grading practices by inquiring into by what circumstances their practices are affected. The study’s theoretical foundation lies within social constructionis
Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. In particular, it is essential to clarify how the endogenous analgesic centres which are present in the brain, s
This paper explores educational desires, parenting and shifting notions of childhood in contemporary Singapore. Singapore’s education system is globally renowned for its high academic standards and for producing students who excel in international assessment tests and rankings. At the same time, there has been a shift of attention in education policy towards social-emotional competencies and well-This paper explores educational desires, parenting and shifting notions of childhood in contemporary Singapore. Singapore’s education system is globally renowned for its high academic standards and for producing students who excel in international assessment tests and rankings. At the same time, there has been a shift of attention in education policy towards social-emotional competencies and well-
The practice of product destruction, whereby retailers or manufacturers dispose of viable consumer products such as unsold goods or customer returns, is an extreme expression of the linearity of our current production-consumption system. This qualitative exploratory study aims to uncover why companies engage in this highly unsustainable and resource-inefficient behaviour and to explore the potenti
The lichen family Teloschistaceae (Teloschistales, lichenized Ascomycota) included ten genera and ca 500 species prior to the molecular era (Kärnefelt 1989). Since then, molecular studies resulted in today's ca 112 genera and ca 1200 species (e.g., Fayyaz et al. 2022; Kondratyuk et al. 2022a, 2022b). New species and genera in the Teloschistaceae, based on recently discovered monophyletic branches,
The new genus Kudratoviella for the former Caloplaca zeorina group having the highest level of bootstrap support in the phylogenetic tree of the Teloschistaceae, based on combined dataset of nrITS, 28S nrLSU DNA and 12S SSU mtDNA sequences, which does not belong to any other earlier proposed genera of the subfamily Xanthorioideae, is described. The genus Oceanoplaca Arup, Søchting et Bungartz founThe new genus Kudratoviella for the former Caloplaca zeorina group having the highest level of bootstrap support in the phylogenetic tree of the Teloschistaceae, based on combined dataset of nrITS, 28S nrLSU DNA and 12S SSU mtDNA sequences, which does not belong to any other earlier proposed genera of the subfamily Xanthorioideae, is described. The genus Oceanoplaca Arup, Søchting et Bungartz foun
Seven species new to science are described, illustrated and compared with closely related taxa. Of them, one species, i.e.: Coppinsidea vernadskiensis S. Y. Kondr., T. O. Kondratiuk et I. Yu. Parnikoza is from the Argentine Islands, Western Maritime Antarctic Peninsula, Jacke lixia hosseussii S. Y. Kondr., L. Lőkös et J.-S. Hur, from South America (Argentina and Uruguay), Loekoeslaszloa reducta YoSeven species new to science are described, illustrated and compared with closely related taxa. Of them, one species, i.e.: Coppinsidea vernadskiensis S. Y. Kondr., T. O. Kondratiuk et I. Yu. Parnikoza is from the Argentine Islands, Western Maritime Antarctic Peninsula, Jacke lixia hosseussii S. Y. Kondr., L. Lőkös et J.-S. Hur, from South America (Argentina and Uruguay), Loekoeslaszloa reducta Yo
The engram encoding the interval between the conditional stimulus (CS) and the unconditional stimulus (US) in eyeblink conditioning resides within a small population of cerebellar Purkinje cells. CSs activate this engram to produce a pause in the spontaneous firing rate of the cell, which times the CS-conditional blink. We developed a Bayesian algorithm that finds pause onsets and offsets in the r
In this book, I advance the concept of gender transculturation to illustrate how migrant consumers navigate contesting gender ideologies in their host cultural marketplace. Taking a consumer cultural theoretical perspective, the study lies in the nexus of and unpacks an alternative understanding in the current research frontier of consumer acculturation, gender and ideologies. Acculturation of imm
The Summary for Urban Policymakers (SUP) initiative provides a distillation of the IPCC reports into accessible and targeted summaries that can help inform action at city and regional scales. Volume I in the series, What the Latest Physical Science of Climate Change Means for Cities, identified the ways in which human-induced climate change is affecting every region of the world, and the cities an
Agroecosystem photosynthesis is key to coping with global climate change. In farmland where human activities are highly involved, the interaction between environmental factors and their influences on gross primary productivity (GPP) are insufficiently understood. Particularly, the irrigation and mulching in water-saving agriculture can alter the crop responses to environmental change. Based on edd
Agricultural ecosystem water use efficiency (WUE) is an important indicator reflecting carbon-water coupling, but its control mechanisms in managed fields remain unclear. In order to reveal the influencing factors of WUE in the agricultural field under mulched drip irrigation (DM), we carried out the 8-year continuous observations in a maize field from Northwestern China. The structural equation m
Efforts to develop effective climate mitigation strategies for agriculture require methods to estimate nitrous oxide (N2O) emissions from soil. Process-based biogeochemical models have been often used for field- and large-scale estimates, while the sensitivity and uncertainty of model applications to incubation experiments are less investigated. In this study, a process-oriented model (CoupModel)
Background: Adipic acid (AA) is one of the most important industrial chemicals used mainly for the production of Nylon 6,6 but also for making polyurethanes, plasticizers, and unsaturated polyester resins, and more recently as a component in the biodegradable polyester poly(butylene adipate terephthalate) (PBAT). The main route for AA production utilizes benzene as feedstock and generates copious
