Background: Food consumption is one of the most important drivers of environmental pressures. Adoption of healthy diets is suggested to be an option for less environmentally intensive food habits and improved public health. In particular, changes in meat consumption are believed to bring potential benefits. Objective: To quantify the impact of changes in meat consumption on the dietary contributio

Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte

Receding glaciers are among the most obvious changes caused by global warming, and glacial meltwater entering lakes generally forms plumes of particles. By taking vertical samples along a horizontal gradient from such a particle source, we found that photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) attenuated 20-25% faster close to the inflow of suspended particles compare

A small number of proteins have the unusual property of tasting intensely sweet. Despite many studies aimed at identifying their sweet taste determinants, the molecular basis of protein sweetness is not fully understood. Recent mutational studies of monellin have implicated positively charged residues in sweetness. In the present work, the effect of overall net charge was investigated using the co

Cyanobacteria living epiphytically on mosses in pristine, unpolluted areas fix substantial amounts of atmospheric nitrogen (N) and therefore represent a primary source of N in N-limited boreal forests. However, the fate of this N is unclear, in particular, how the fixed N-2 enters the soil and becomes available to the ecosystem. In this study, we applied N-15-ammonium chloride (N-15-NH4Cl) onto ca

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with

Blood coagulation and complement pathways are two important natural defense systems. The high affinity interaction between the anticoagulant vitamin K-dependent protein S and the complement regulator C4b-binding protein (C4BP) is a direct physical link between the two systems. In human plasma, similar to 70% of total protein S circulates in complex with C4BP; the remaining is free. The anticoagula

Immune cells within the tumor can act either to promote growth or rejection of tumor cells. The aim of the present study was to evaluate immune cell markers (number and localization) within the tumor before and during rejection due to radioimmunotherapy, to determine whether there is a change in markers related to rejection and/or tolerance of the tumor cells.

Control of haemorrhage is vital in all operative settings. As complement to traditional surgical haemostatic techniques, a heterogeneous collection of absorbable substances with haemostatic capacity have been developed; topical haemostatic agents. The widespread variety of the products and the study-populations (clinical or experimental) make interpretation of previously performed studies difficul

Aims Delcasertib is a selective inhibitor of delta-protein kinase C (delta-PKC), which reduced infarct size during ischaemia/reperfusion in animal models and diminished myocardial necrosis and improved reperfusion in a pilot study during primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI). Methods and results A multicentre, double-blind trial was perform

In this article, we analyse the evolution and transformation of Danish spatial planning from its tentative origins in liberalist politics, through its rise as a central feature of the welfare state project, to its more recent entrepreneurial forms in a context of neoliberalisation. The article demonstrates how transformations of Danish spatial planning discourses and practices must be understood i

Integrated Water Resources Management (IWRM) is a relatively new approach in Bolivia. However, it is now generally accepted that this approach needs to be established in order to find sustainable solutions for development and is actively promoted by the Water Ministry, especially in environmentally fragile regions, such as the Lake Poopo basin. The Lake Poopo basin is one of the poorest regions in

Ultraviolet radiation (UVR) causes physical damage to DNA, carboxylation of proteins and peroxidation of lipids in copepod crustaceans, ubiquitous and abundant secondary producers in most aquatic ecosystems. Copepod adaptations for long duration exposures include changes in behaviour, changes in pigmentation and ultimately changes in morphology. Adaptations to short-term exposures are little studi

The far-infrared spectra of solid orthodeuterium and solid normal deuterium are presented and compared to the corresponding spectra of solid parahydrogen and solid normal hydrogen. Spectra of water in orthodeuterium are compared to spectra of water in parahydrogen. The water rotation constants in orthodeuterium are approximately 80% of the rotation constants of water in parahydrogen. The S(0)(0) b

Objective: To evaluate the ability of a postnatal weight-gain algorithm (WINROP) to identify sight-threatening retinopathy of prematurity (ROP type 1) in a nation-based extremely preterm infant cohort. Methods: This study enrolled all 707 live-born extremely preterm (gestational age [GA]