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The impact of tourism research

The exceedingly competitive climate of academia has increased the emphasis on performance-based research funding. In this paper we evaluate the UK's government assessment of research impact and critically comment upon the implications for future research conduct. The key findings are as follows; firstly we provide a summary of UK tourism research impact. Secondly, we demonstrate the effect of the

A Deep Learning Approach to MR-less Spatial Normalization for Tau PET Images

The procedure of aligning a positron emission tomography (PET) image with a common coordinate system, spatial normalization, typically demands a corresponding structural magnetic resonance (MR) image. However, MR imaging is not always available or feasible for the subject, which calls for enabling spatial normalization without MR, MR-less spatial normalization. In this work, we propose a template-

Young Somalis’ social identity in Sweden and Britain : The interplay of group dynamics, socio-political environments, and transnational ties in social identification processes

In this article, we aim to contribute to the literature on social identification among migrants and minorities by offering a theoretical framework that accounts for the interplay of socio-psychological factors, local and transnational group dynamics, and the socio-political environment in which migrants live. This approach enables us to analyse not only the political significance of identity, but

Copenhagen Head Injury Ciclosporin Study : A Phase IIa Safety, Pharmacokinetics, and Biomarker Study of Ciclosporin in Severe Traumatic Brain Injury Patients

Traumatic brain injury (TBI) contributes to almost one third of all trauma-related deaths, and those that survive often suffer from long-term physical and cognitive deficits. Ciclosporin (cyclosporine, cyclosporin A) has shown promising neuroprotective properties in pre-clinical TBI models. The Copenhagen Head Injury Ciclosporin (CHIC) study was initiated to establish the safety profile and pharma

Swedish word accents, intonation and L2 English : Aligning tonal, metrical and morphosyntactic structure during L2 processing

Mastering a new language (L2) implies the need to readjust the associations between different components (phonology, lexicon, grammar) in the native language (L1). L2 speakers have often been observed to apply prosodic patterns from their first language when processing a new language. Swedish speakers have been reported to produce a word melody that resembles accent 1 when speaking foreign languag

Pretreatment for biorefineries : A review of common methods for efficient utilisation of lignocellulosic materials

The implementation of biorefineries based on lignocellulosic materials as an alternative to fossil-based refineries calls for efficient methods for fractionation and recovery of the products. The focus for the biorefinery concept for utilisation of biomass has shifted, from design of more or less energy-driven biorefineries, to much more versatile facilities where chemicals and energy carriers can

Beta-blocker therapy and risk of vascular dementia : A population-based prospective study

There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2,

Parametric study on flow characteristics and heat transfer in rectangular channels with strip slits in ribs on one wall

Augmentation of heat transfer must always be judged against an additional pressure loss. To this context, this paper explores slitted ribs on the turbulent flow and heat transfer characteristics in rectangular cooling channels with an aspect ratio of 4:1. A verified v2f turbulence model is applied in the present numerical simulations in the Reynolds number range from 20,000 to 80,000. The flow and

Deletion of IRF4 in Dendritic Cells Leads to Delayed Onset of T Cell-Dependent Colitis

Classical dendritic cells (cDC) can be classified into two major subsets: Irf8-dependent cDC1 and Irf4-expressing cDC2. Although these subsets play distinct roles in intestinal immune homeostasis, their functions in T cell-driven colitis remain unknown. To assess the role of IRF4 expression in cDC2 in T cell-driven colitis, CD11c-Cre.Irf4fl/fl and Irf4fl/fl mice were backcrossed onto a Rag-1-/- ba

Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy : Experience from the Nordic ARVC Registry

Background: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestat

Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk

Objective: The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls. Methods: The variants in the TL

Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates

AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and beta cell mass.METHODS: Pancreas tissue from 15 non-diabetic organ donors who were positive for islet