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Immune checkpoint blockade (ICB) therapy can restore T cell function in tumors, but not all patients benefit, and the mechanisms behind this remain unclear. In this study, we used patient-derived organotypic (PDO) cultures from metastatic melanoma to examine transcriptomic and cellular changes following ex vivo T cell stimulation. Genomic and transcriptomic features were preserved during PDO forma
Lars Marcus’s book Städernas stenar (The stones of cities) presentsbasic concepts and the latest directions in the space syntax researcharea. Marcus’s presentation is based on the necessity of understandingthat urban planning as an area of knowledge is comprised of the materialreality of both the city and the “lived city”, human beings, and their useof the city as a tool, of being comprehended as
AbstractAim: This study sought to investigate the hypothesis that children dying outside a pediatric intensive care unit (PICU) after PICU discharge have a limitation of medical treatment (LOMT) order in place, limiting PICU readmission at the time of death.Methods: A cohort was identified of all children (n=3890; 5019 admissions) treated in a PICU in Sweden over 3 consecutive years between Januar
BACKGROUND: Head impacts are common in contact sports such as boxing and occur at times of elevated core body and brain temperatures induced by the exercise. Following impact, elevated brain temperature may lead to the development of exacerbated brain injury that can be monitored by blood biomarkers. Blood-brain biomarkers S100B and glial fibrillary acidic protein (GFAP) reflect glial injury; neur
We consider the verification of neural network policies for discrete-time stochastic systems with respect to reach-avoid specifications. We use a learner-verifier procedure that learns a certificate for the specification, represented as a neural network. Verifying that this neural network certificate is a so-called reach-avoid supermartingale (RASM) proves the satisfaction of a reach-avoid specifi
The aim of this study is to explore the internal damage mechanisms of AlSi12 metal matrix syntactic foam (MMSF) with embedded ceramic hollow spheres (CHSs) to understand the damage behavior during compressive loading. To achieve this goal, in situ synchrotron X-ray tomography is used. A qualitative and quantitative assessment of the initiation and gradual collapse of matrix, filler material, and p
Early recognition and management of sports-related concussion (SRC), including removal from the sports activity, is essential for player safety and to prevent long-term symptoms. A graduated, stepwise rehabilitation protocol is implemented to allow the athlete to return to sports. In 2022, the 6th international consensus statement on concussion in sports was presented, which has now been adapted t
Background and purpose — Musculoskeletal deformities in cerebral palsy (CP) may be surgically treated, but population-based studies of postoperative complications after these surgeries are rare. The aim of our study was to assess the risk of complications following elective orthopedic surgery in children and young adults with CP. Methods — We performed a register-based cohort study of 1,514 indivi
This paper integrates the concepts of first and second stories as well as Symbolic Interactionism and provides a framework that emphasizes the local rationality of practitioners and the social construction of meaning within their organizations. This paper will first consider some of the assumptions that characterize today’s safety discourse(s) because they inform how CS works with clients. What Sy
Artikel om de utrikespolitiska förbindelserna mellan Sverige och USA från ett jubileum 1938 (New Sweden Tercentenary Celebration) till ett annat 1948 (Swedish Pioneer Centennial).
Depression is a debilitating psychiatric disorder. Electroconvulsive therapy (ECT) and ketamine are effective treatments for severe depression, but target populations may differ. Systematic reviews on the few available trials show higher remission rates with ECT than with ketamine. Nonetheless, ketamine’s rapid onset of action is comparable to ECT but with less cognitive adverse effects. This make
The Polarization and Impedance Controlled Car (PICC) presents an innovative approach for demonstrating and teaching key principles of electromagnetic field theory, specifically polarization and impedance. Designed as an interactive learning tool, the PICC utilizes a radio-controlled car, NanoVNA, Raspberry Pi, and handheld antennas to visualize real-time effects of polarization and impedance. The
This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then co
Micro-LEDs have emerged as a hot research topic due to their potential for next-generation display and lighting applications, necessitating advanced characterization techniques to optimize their performance. This study demonstrates the advantage of cathodoluminescence in the scanning electron microscope to be a critical tool for the optical characterization of InGaN platelets with red quantum well
The retreat of the modern liberal order in contemporary democracies can be understood as co-constituted with the normalisation of the far right. The far right has increasingly accessed the political ‘mainstream’ through the enabling of erstwhile-disavowing centre-right and right-wing counterparts. In contexts of political ‘victory’, the identity (re)formation of these mainstream right-wing subject
Background Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive protein (CRP), blood eosinophils (B-Eos), blood neutrophils (B-Neu), blood lymphocytes (B-Lym), bloo
Future studies are methodological tools that have affected policy design over the past decades. In Peru, these tools have developed hand in hand with a cycle of institutional volatility in a context of socioeconomic and political turmoil. While the context has improved, the relevance of future studies in relation with policy design is still questionable. New approaches developed and implemented by
Pathogenic variants of human CDC14A (cell division cycle 14A) are associated either with nonsyndromic deafness DFNB32 or HIIMS, hearing impairment infertile male syndrome. The 623-residue CDC14A protein has two globular domains (residues 17-152 and 217-325) and a 278-residue C-terminal intrinsically disordered region (IDR). To date, 16 recessive variants of human CDC14A are associated with hearing
While fiscal policy making in the EU is in the hands of national governments, it is to be carried out in accordance with commonly agreed rules: the Stability and Growth Pact (SGP). The SGP originates in the understanding that uncoordinated fiscal policy produces cross-border effects that can harm the functioning of the Economic and Monetary Union. For member states with an excessive deficit, that
