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Homomeric coiled-coils can self-assemble into a wide range of structural states with different helix topologies and oligomeric states. In this study, we have combined de novo structure modeling with stability calculations to simultaneously predict structure and oligomeric states of homomeric coiled-coils. For dimers an asymmetric modeling protocol was developed. Modeling without symmetry constrain

The article examines Singaporeans' experiences of upward social mobility and how traditional gender roles within the family are renegotiated and reinterpreted in Singapore. When the former British colony gained independence in 1965 its post-colonial government embarked on an ambitious modernization programme, under which villages were demolished and residents relocated to new high-rise estates, fa

The electron transport properties of a topological insulator Bi2Se3 thin film are studied in Hall-bar geometry. The film with a thickness of 10 nm is grown by van der Waals epitaxy on fluorophlogopite mica and Hall-bar devices are fabricated from the as-grown film directly on the mica substrate. Weak antilocalization and electron-electron interaction effects are observed and analyzed at low temper

Bengt Johannisson received the International Award for Entrepreneurship and Small Business Research in 2008. In this essay we present and evaluate his work over the last four decades in three of its dimensions: pioneering, provocative and participative. While his research interests and themes range widely, early on he resisted the individualization of entrepreneurship studies and instead emphasize

This article presents a polar diagram method developed for describing and evaluating the potential machinability of different workpiece materials. The potential machinability is examined in terms of five critical properties of the workpiece material. Two groups of materials, a group of common steel grades and the other a group of stainless steels, were examined in detail, their polar diagrams illu

In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enh

Speculation remains that growth hormone (GH) treatment is associated with increased neoplasia risk. Studies in GH-treated childhood cancer survivors suggested higher rates of second neoplasms, while cancer risk data for GH-treated and untreated hypopituitary adults have been variable. We present primary cancer risk data from the Hypopituitary Control and Complications Study (HypoCCS) with a focus

According to the classical perspective, polity size and democracy are inversely related. In this article, we argue that there is an important exception that manifests itself at the district level in settings where multiparty competition is allowed. Specifically, we find that larger districts encourage greater contestation. This results from a little-noticed mechanical effect as well as from severa

Clinical oncology is advancing toward a more personalized treatment orientation, making the need to understand the biology of metastasis increasingly acute. Dissecting the complex molecular, genetic and clinical phenotypes underlying the processes involved in the development of metastatic disease, which remains the principal cause of cancer-related deaths, could lead to the identification of more

Objective: To analyze screening for retinopathy of prematurity (ROP) during a 3-year period in a national cohort of infants born before 27 weeks' gestation. Methods: A national prospective study of neonatal morbidity in extremely preterm infants was performed in Sweden between April 1, 2004, and March 31, 2007. Screening for ROP was to start in the fifth postnatal week and to continue weekly until

BACKGROUND: The objective of this study was to assess, in a large data set from Swedish Medical Health Registries, whether maternal obesity and maternal morbid obesity were associated with an increased risk for various structural birth defects. METHODS: The study population consisted of 1,049,582 infants born in Sweden from January 1, 1995, through December 31, 2007, with known maternal weight and

The self-assembly of a true ternary mixture comprising an electroneutral complex of DNA anions and surfactant cations (dodecyltrimethylammonium cations, DTA), water, and nonionic surfactant (monoolein, MO) has been studied. The phase diagrams of two systems, DTA-DNA/MO/water and, for comparison, dodecyltrimethylammonium bromide (DTAB)/MO/water, were obtained by visual inspection, microscopic exami

Strained InGaN/GaN core-shell nanowires (NWs) are promising candidates for solid state lighting applications due to their superior properties compared to planar films. NW based devices consist of multiple functional layers, which sum up to many hundred nanometers in thickness, that can uniquely be accessed in a non-destructive fashion by hard X-rays. Here, we present a detailed nanoscale strain ma

The innate immune system is the first line of defense against invading microbes. Its specificity relies a great deal on host pattern recognition molecules that sense pathogen-associated molecular patterns of the invading pathogen. However, full protection is not always guaranteed, and some early defense mechanisms involved in bacterial killing, such as the complement system, can also exert cytolyt

Definition of individual risk profile is the first step to implement strategies to keep the delicate balance between under- and overimmunosuppression after kidney transplantation.

A measurement of the Lambda(0)(b) lifetime and mass in the decay channel Lambda(0)(b) -> J/psi (mu(+) mu(-))Lambda(0)(p pi(-)) is presented. The analysis uses a signal sample of about 2200 Lambda(0)(b) and (Lambda) over bar (0)(b) decays that are reconstructed in 4.9 fb(-1) of ATLAS pp collision data collected in 2011 at the LHC center-of-mass energy of 7 TeV. A simultaneous mass and decay time ma

It is widely believed that the light induced degradation of crystalline silicon solar cells is due to the formation of a BsO2i recombination center created by the optically excited migration of the oxygen dimer (charge-state-driven motion). In this letter the concentration dependence of the neutral state of O-2i on [O-i] in p- and n-type Cz-Si has been determined using infrared absorption. A syste