ABSTRACT: BACKGROUND: Renal function decreases with age. Dosage adjustment according to renal function is indicated for many drugs, in order to avoid adverse reactions of medications and/or aggravation of renal impairment. There are several ways to assess renal function in the elderly, but no way is ideal. The aim of the study was to explore renal function in elderly subjects in nursing homes and

In the present paper we give a general two-dimensional formalism for scattering in a multilayered medium with a finite inhomogeneity present. The formalism is based on the T matrix method, introduced by Waterman [J. Acoust. Soc. Am. 45, 1417 (1969)]. The formalism is developed in detail for the geometries consisting of one layer with an obstacle situated either inside or below the layer. More gene

The subject of this paper is to calculate the fields in a layered earth induced by a current distribution. A general formulation is presented, which contains very few restrictions of the current distribution. For the simplest current distributions (dipole, circular, and rectangular loops) we derive expressions for the fields, which contain a single integral (Sommerfeld type). Numerical computation

A 12-bit 125-MHz digital-to-analog converter (DAC) for communication application is designed. It is based on current-steering segmented architecture and modified Q2 random walk switching scheme to obtain 12-bit accuracy. A new voltage swing reduced driver (VSRD) is implemented to promote the dynamic performance. The DAC uses 0.18 µm 1.8 V standard digital CMOS technology. The die area (core) is 2.

This paper is based on the findings of a research work by Abukhader and Jönson (2004a), who discuss the possibilities and limitations of the ties of postponement strategy in food supply chains. They identified the cases/examples (i.e. company cases) of application of postponement across the various categories of foods: frozen, chilled/fresh and long shelf life. The food industry nowadays is in nee

Objective: To assess whether a genetic risk score that was previously shown to be associated with myocardial infarction and coronary artery disease is also associated with markers of carotid atherosclerosis. Design: A total of 4022 middle-aged subjects from the general Swedish population were genotyped and individually assigned a genetic risk score based on 13 single-nucleotide polymorphisms (SNPs

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of che

All Swedish new-born infants were screened for alpha-1-antitrypsin (AAT) deficiency in 1972-74. The cohort of 127 PiZZ and 54 PiSZ individuals has been followed-up regularly.

A huge quantity of gene and protein sequences have become available during the post-genomic era, and information about genetic variations, including amino acid substitutions and SNPs, is accumulating rapidly. To understand the effects of these changes, it is often essential to apply bioinformatics tools. Where there is a lack of homologous sequences or a three-dimensional structure, it becomes ess

Experimental oscillator strengths for 19 ultraviolet lines of Pd II have been derived from measurements of line intensities in calibrated Fourier transform spectra, combined with picosecond-pulse laser measurements of radiative lifetimes. Five of these 19 lines, in addition to other Pd nr lines, are present in Hubble Space Telescope/Goddard High-Resolution Spectrograph echelle spectra of the chemi

BACKGROUND: Suicide attempts have been shown to be less common in older age groups, with repeated attempts generally being more common in younger age groups and severe attempts in older age groups. Consistently, most studies have shown an increased suicide risk after attempts in older age. However, little is known about the predictive value of age on repeated and severe suicide attempts for accomp

While Aristotle has conventionally been perceived as a precursor for the taxonomy of modern biological systematics, such as that of Carolus Linnaeus, this essay investigates the relationship between Aristotelian metaphysics and natural history in order to demonstrate the problem of anomalies in any system of this kind. In particular, the problem involves the place that may be given to the unnatura

Aortoenteric fistula formation is a devastating condition regardless of whether it is primary or secondary (i.e. after previous aneurysm repair) in nature. Patients present with signs and symptoms of gastrointestinal bleeding with or without signs of systemic infection and are often in a very poor clinical condition. Conventional treatment consists of extensive open surgery (extra-anatomical bypas

Building on previous work showing that eye gaze plays a role during moral decision-making and that the underlying mechanisms might be characterised as a fixation dependent drift-diffusion process, donation decisions between charitable organisations were studied. Models were fit with full, no or partial fixation dependence. Results indicate the model with partial fixation dependence provided the be

Wang F, Xia J, Chen J, Peng Y, Cheng P, Ekberg H, Wang X, Qi Z. Combination of antibodies inhibits accelerated rejection mediated by memory T cells in xenoantigen-primed mice. Xenotransplantation 2010; 17: 460-468. © 2010 John Wiley & Sons A/S. Abstract: Background: Donor-reactive memory T cells are known to accelerate allograft rejection; in our previous study, we reported that combined monoc