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1. Permutation tests are important in ecology and evolution as they enable robust analysis of small sample sizes and control for various forms of dependencies among observations. A common source of dependence is spatial autocorrelation. Accounting for spatial autocorrelation is often crucial, because many ecological and evolutionary processes are spatially restricted, such as gene flow, dispersal,
Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. However, the target of this drug has remained unclear. In this study, we applied diverse strategies to identify the histone deacetylase HDAC4 as a target for the antiangiogenic activity of tasquinimod. Our comprehensive analysis revealed allo
Professional cycling combines extensive endurance training with non weight-bearing exercise, two factors often associated with lower bone mineral density (BMD). Therefore BMD was measured with dual-energy x-ray absorptiometry in 30 professional road cyclists (mean (SD) age: 29.1 (3.4) years; height: 178.5 (6.7) cm; weight: 71.3 (6.1) kg; %fat mass: 9.7 (3.2)%; (V) over dotO(2) max: 70.5 (5.5) ml .
Popular Abstract in Swedish Varje år insjuknar ca 7000 kvinnor i Sverige i bröstcancer och antalet ökar för varje år. Fortfarande är kunskapen om orsakerna till bröstcancer relativt okända, men många av de kända riskfaktorerna är kopplade till en hög halt av könshormoner i blodet. Faktorer i kosten som kan motverka effekten av könshormonerna är därför av stort intresse. Under 1990-talet inbjöds Diets high in fibre have previously been associated with decreased risk of breast cancer in the Malmö Diet and Cancer cohort. Several potent compounds may exist in high-fibre diets that might protect against breast cancer, for example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen r
Although chemical functionalization of single-walled carbon nanotubes was extensively studied, in many cases detailed information about the influence of the nanotube metallicity and diameter is missing. Here, we present an X-ray photoemission and absorption spectroscopy study of endohedrally functionalized carbon nanotubes with different diameters, where Ni(II) acetylacetonate molecules are reacte
ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric
This study uses Swedish accident data for the years 2004–2008 to analyze the relationship between injury severity for pedestrians struck by a vehicle and the speed environment at accident locations. It also makes use of a multinomial logit model and other statistical methods. Speed measurements have been performed at accident sites, and the results show that there was a relationship between the (1
Fotosyntesen är växternas fantastiska och för oss livgivande metod att med hjälp av energin i solljuset omvandla luftens koldioxid till växtbiomassa och syre. Men många lägre organismer har en fotosyntes som inte producerar nŒgot syre, medan åter andra organismer kan binda koldioxid med hjälp av någon annan energikälla än solljuset. Lars Olof Björn och Jan Bergström reder ut begreppen.
Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European
Background. The acronym ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) highlights that children seeking clinical treatment are often multiply impaired, thus requiring treatment from several specialties. The aim was to map and relate, on a population level, ESSENCE to two salient predictors of health and adaptation to adversities, namely, Self-Directedness
Luthers kombination av Guds-ords-mystik och kallelsemedvetande blir så tydlig att den just därför varit svår att förstå. Stolt gör upp med vanföreställningar som att retorik skulle utesluta spontanitet. Hon utgår från språkvetenskapliga iakttagelser: Luthers latinska och tyska språkanvändning står i intensivt beroende av varandra, och hans nyskapande insatser för det tyska språket kan inte isolera
Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in labora
In order to evaluate the success of simple heuristics we need to know more about how a relevant heuristic is chosen and how we learn which cues are relevant. These meta-abilities, we believe, are at the core of ecological rationality, rather than the individual heuristics.
