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Cumulative risk assessment of five phthalates in European children and adolescents

The European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, t

Human Biomonitoring Data in Health Risk Assessments Published in Peer-Reviewed Journals between 2016 and 2021 : Confronting Reality after a Preliminary Review

Human biomonitoring (HBM) is a rapidly developing field that is emphasized as an important approach for the assessment of health risks. However, its value for health risk assessment (HRA) remains to be clarified. We performed a review of publications concerned with applications of HBM in the assessment of health risks. The selection of publications for this review was limited by the search engines

Exposure of men and lactating women to environmental phenols, phthalates, and DINCH

Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chemicals of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating

Organohalogens : A persisting burden in Slovenia?

Persistent organic pollutants (POPs) represent a concern for the environment and human health due to their persistence and toxicity. Exposure in Slovenia is geographically differentiated because the country, as part of former Yugoslavia, has a history of industry and regional contamination and is – at the same time – known for its clean nature. The PCB pollution of the Krupa River drew the public'

Urinary phthalate concentrations in the slovenian population : An attempt to exposure assessment of family units

Phthalates are widespread contaminants with differing chemical characteristics, which largely determine their product applications, and they can leach into the environment. Due to their endocrine disruptive properties at long-term low-level exposure, they propose a health threat to people that has been associated with several adverse health effects such as: decreased male fertility and impacts on

Temporal Changes in Concentrations of Lead and Other Trace Metals in Free-Ranging Eurasian Eagle Owls Bubo bubo in Sweden

Patterns of lead and other trace metals were examined in 122 Eurasian eagle owls Bubo bubo found dead in Sweden in the period 1978–2013. Environmental lead (Pb) has decreased over recent decades from reduced anthropogenic emissions but mortality by Pb poisoning is still frequently reported for avian raptors and scavengers exposed to Pb ammunition. One objective here was to determine if Pb concentr

Primed into security: can attachment security priming affect attachment-related biases on early attention?

Attachment avoidance is associated with deactivation of the attachment system when distressed, and disengagement from distressing information to maintain felt security. This study investigated how experimentally induced priming to enhance felt security might influence avoidant strategies at an attentional level. In a randomized, mixed design (N=104), we assessed attentional vigilance/disengagement

QUANTIFYING THE FLOW PATHWAY FEATURES IN FORESTS OF A ROCKY MOUNTAIN USING MULTI-TRACER

Preferential pathways are crucial channels for water and solute infiltration. To better investigate the features of flow pathways in forest soils, multi-tracer (Brilliant Blue and NaBr) experiments were conducted in pure forests dominated by Quercus variabilis BI., and Platycladus orientalis (L.) Franco., respectively. Additionally, the total infiltration depth of 40 mm was selected. In the soil l

CROWDSOURCING AND ONLINE APP IN URBAN FLOOD MANAGEMENT

A common and huge challenge in risk and disaster management such as urban flood is the lack of effective communication, especially instant communication from the general public when sudden flooding occurs. There is a strong need to facilitate complementary risk management for authorities to communication with public in addition to mainstream channels. In a recent international project, possibility

Co-creating Value in the Scandinavian Welfare System : Matching Elderly Care in a Major Swedish Municipality

The concept of a socially sustainable society is linked to the notion of equal access to high-quality welfare services and an equitable distribution of common resources. The rationale behind the introduction of private actors to provide welfare services is that greater choice will result in higher quality of service for individuals, achieved through a co-creation process. The purpose of this study

On the evolution of floral traits : Variation in complex floral phenotypes across pollination environments

Pollinators play a central role in shaping the astounding diversity of angiosperm flowers. Flowers are complex, multidimensional, genetically and functionally integrated phenotypes, rendering it a challenge to quantify and interpret observed trait variation. Even variation in simpler trait measurements is a challenge to interpret, because of the multitude of selective agents and evolutionary proce

High-energy-density acoustofluidic device using a double-parabolic ultrasonic transducer

High-acoustic-energy-density acoustofluidic devices are necessary to make this technology a viable option for clinical applications in the biomedical field. We present a mechanical interface that enables delivery of a high-amplitude acoustic field inside a fluid cavity by translating the vibrations from two large piezoelectric elements into a microfluidic chip. The study comprises both experimenta

Operando Investigation of WS2 Gas Sensors : Simultaneous Ambient Pressure X-ray Photoelectron Spectroscopy and Electrical Characterization in Unveiling Sensing Mechanisms during Toxic Gas Exposure

Ambient pressure X-ray photoelectron spectroscopy (APXPS) is combined with simultaneous electrical measurements and supported by density functional theory calculations to investigate the sensing mechanism of tungsten disulfide (WS2)-based gas sensors in an operando dynamic experiment. This approach allows for the direct correlation between changes in the surface potential and the resistivity of th

Scenarios for the long-term efficacy of amyloid-targeting therapies in the context of the natural history of Alzheimer's disease

INTRODUCTION: Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer's disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease trajectory is not yet understood. We propose a framework for evaluating realistic long-term scenarios. METHODS: Results from recent phase 3 trials of Aβ-targeting antibodies were integrated with an estim

AI Act high-risk requirements readiness : industrial perspectives and case company insights

The AI Act’s (AIA) requirements for high-risk AI systems affect many aspects of modern software systems. Knowing which AIA-related technical challenges are relevant to different companies is essential to focus compliance-oriented research on the aspects that matter. We therefore conducted an interview study in collaboration with a case company that specializes in network video solutions within the

Clinical impact of circulating biomarkers in prediction of adverse cardiac events in patients with congenital heart disease. A systematic review

IntroductionPatients with congenital heart disease (ConHD) are at increased risk for adverse cardiac events. Predicting long-term outcomes and guidance of patient management might benefit from a range of (new) biomarkers. This is a rapidly evolving field with potentially large consequences for clinical decision making. With a systematic review of available biomarkers in ConHD we identified the cli

Modeling the recent drought and thinning impacts on energy, water and carbon fluxes in a boreal forest

Globally, boreal forests act as important carbon sinks, however, drought and forest management could substantially alter the sink strength, though the controlling mechanisms of drought and management remain unclear. In this study, we combined the detailed process-based CoupModel with multiple measurements to study the impacts of recent drought and forest thinning on a boreal forest during 2018–202

Nerve regeneration in healthy and diabetic rat sciatic nerves : Influence of timing, a novel scaffold and the lactoferrin-derived peptide PXL01

Repair or reconstruction after a peripheral nerve injury is a challenge because functional outcome is still unsatisfactory. Treatment in patients with diabetes may be further demanding. Nerve regeneration after nerve injury was investigated, using various repair and reconstruction models, including immediate and delayed repair, bioengineered conduits, or nerve autografts as well as a possibility t

European Law Moot Court Competition, History, Cases & Materials

The book offers an overview of the history, cases and material of the European Law Moot Court Competition (ELMC). The ELMC is today considered the most prestigious moot court within the field of European Union Law and one of the most important moot court competitions in the world.Published at the occasion of the 35th anniversary of the competition, the book aims to both motivate students and guide