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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without di

Genetic dissection of serum vaspin highlights its causal role in lipid metabolism

Objective: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity-related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. Methods: A meta-analysis of genome-wide association studies for serum vaspin f

All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults

OBJECTIVE Latent autoimmune diabetes in adults (LADA) is a heterogenous, slowly progressing autoimmune diabetes. We aim to contribute new knowledge on the long-term prognosis of LADA with varying degrees of autoimmunity by comparing it to type 2 diabetes and adult-onset type 1 diabetes. RESEARCH DESIGN AND METHODS This Swedish population-based study included newly diagnosed LADA (n = 550, stratifi

Digital lifestyle treatment improves long-term metabolic control in type 2 diabetes with different effects in pathophysiological and genetic subgroups

To address the unmet need for scalable solutions for lifestyle treatment, we developed a new digital method to promote behavioral change. Here we report that patients with type-2 diabetes in Sweden (n = 331) exposed to the intervention have significantly improved HbA1c during a median follow-up of 1038 days (4 mmol/mol compared with matched controls; P = 0.009). This is paralleled by reduced body

Measurements of Zγ+jets differential cross sections in pp collisions at √s = 13 TeV with the ATLAS detector

Differential cross-section measurements of Zγ production in association with hadronic jets are presented, using the full 139 fb −1 dataset of s = 13 TeV proton–proton collisions collected by the ATLAS detector during Run 2 of the LHC. Distributions are measured using events in which the Z boson decays leptonically and the photon is usually radiated from an initial-state quark. Measurements are mad

Physiology of chemoheterotrophic thermoanaerobes

The industry is increasingly discovering the potential of strict anaerobic thermophilic bacteria, as there are many applications to consider, including the production of stable thermozymes and degradation of lignocellulosic materials, proteins, and alkanes. However, the metabolism of these thermoanaerobes is still poorly understood and so far, there is comprehensive knowledge of only a few model s

Charged-hadron production in pp, p+Pb, Pb+Pb, and Xe+Xe collisions at √sNN = 5 TeV with the ATLAS detector at the LHC

This paper presents measurements of charged-hadron spectra obtained in pp, p+Pb, and Pb+Pb collisions at s or sNN = 5.02 TeV, and in Xe+Xe collisions at sNN = 5.44 TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb −1, 28 nb −1, 0.50 nb −1, and 3 μb −1, respectively. The nuclear modification factors RpPb and R AA are obtained by comparing the spectr

Measurement of the properties of Higgs boson production at √s = 13 TeV in the H → γγ channel using 139 fb−1 of pp collision data with the ATLAS experiment

Measurements of Higgs boson production cross-sections are carried out in the diphoton decay channel using 139 fb−1 of pp collision data at s = 13 TeV collected by the ATLAS experiment at the LHC. The analysis is based on the definition of 101 distinct signal regions using machine-learning techniques. The inclusive Higgs boson signal strength in the diphoton channel is measured to be 1.04−0.09+0.10

Obesity-associated changes in molecular biology of primary breast cancer

Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC differs according to patients’ body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent i

Production of biofuels by thermoanaerobic bacteria

Biofuel demand is gradually rising yearly and is expected to do so more rapidly due to the current energy crisis. Bioethanol production is already at a commercial scale but is primarily made using mesophiles fermenting corn and sugar, which have obvious societal drawbacks. Therefore, new technologies should be developed. In addition, hydrogen as a non-carbon energy carrier has gained renewed inter

Spatio-temporal variability of the earth’s surface temperature and the changes in land user/land cover : implications for sustainable tourism development

Tourism both contributes to environmental change and is, in turn, affected by such change. One area that is of considerable significance is tourism’s contribution to land use change and its subsequent impacts. Land use change, such as tourism urbanization, together with global heating leads to an increase in surface temperature and deterioration in environmental quality and human comfort levels. U

Determination of the strong coupling constant from transverse energy-energy correlations in multijet events at √s = 13 TeV with the ATLAS detector

Measurements of transverse energy-energy correlations and their associated azimuthal asymmetries in multijet events are presented. The analysis is performed using a data sample corresponding to 139 fb −1 of proton-proton collisions at a centre-of-mass energy of s = 13 TeV, collected with the ATLAS detector at the Large Hadron Collider. The measurements are presented in bins of the scalar sum of th

TESS and CHEOPS discover two warm sub-Neptunes transiting the bright K-dwarf HD 15906

We report the discovery of two warm sub-Neptunes transiting the bright (G = 9.5 mag) K-dwarf HD 15906 (TOI 461, TIC 4646810). This star was observed by the Transiting Exoplanet Survey Satellite (TESS) in sectors 4 and 31, revealing two small transiting planets. The inner planet, HD 15906 b, was detected with an unambiguous period but the outer planet, HD 15906 c, showed only two transits separated

Deep-Learning Based High-Precision Localization with Massive MIMO

High-precision localization and machine learning (ML) are envisioned to be key technologies in future wireless systems. This paper presents an ML pipeline to solve localization tasks. It consists of multiple parallel processing chains, each trained using a different fingerprint to estimate the position of the user equipment. In this way, ensemble learning can be utilized to fuse all chains to impr

Inclusive-photon production and its dependence on photon isolation in pp collisions at √s = 13 TeV using 139 fb −1 of ATLAS data

Measurements of differential cross sections are presented for inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13 TeV provided by the LHC and using 139 fb −1 of data recorded by the ATLAS experiment. The cross sections are measured as functions of the photon transverse energy in different regions of photon pseudorapidity. The photons are required to be isolated b

A Hybrid Antenna Switching Scheme for Dynamic Channel Sounding

Channel sounding is essential for the development of radio systems. One flexible strategy is the switched-array-based channel sounding, where antenna elements are activated at different time instants to measure the channel spatial characteristics. Although its hardware complexity is decreased due to fewer radio-frequency (RF) chains, sequentially switching the antenna elements can result in aliasi

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~ 43,800) of SK-BMD, identifying 59 loci, collectively explaining 12.5% of the trait variance. Association signals cluster within gene-sets involved in

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High-precision cellular-based localization is one of the key technologies for next-generation communication systems. In this paper, we investigate the potential of applying machine learning (ML) to a massive multiple-input multiple-output (MIMO) system to enhance localization accuracy. We analyze a new ML-based localization pipeline that has two parallel fully connected neural networks (FCNN). The