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African tropical rainforest net carbon dioxide fluxes in the twentieth century

The African humid tropical biome constitutes the second largest rainforest region, significantly impacts global carbon cycling and climate, and has undergone major changes in functioning owing to climate and land-use change over the past century. We assess changes and trends in CO2 fluxes from 1901 to 2010 using nine land surface models forced with common driving data, and depict the inter-model v

Rare emergence of symptoms during long-term asymptomatic E. coli 83972 carriage, without altered virulence factor repertoire.

Asymptomatic bacteriuria (ABU), established by intravesical inoculation of E.coli 83972, is protective in patients with recurrent UTI. In an RCT cross-over study, two patients developed three symptomatic UTI episodes while carrying E.coli 83972. This study examined if a reacquisition of virulence by symptom isolates may account for the switch from ABU to symptomatic UTI.

Analysis of the volume averaging relations in continuum mechanics

In this paper volume average relations related to the multilevel modeling process in continuum mechanics are analyzed and the concept of average consistency is investigated both analytically and numerically. These volume averages are used in the computational homogenization technique, where a transition of the mechanical properties from the local, microscopic, to the global, macroscopic, length sc

Inclusive cross section and double-helicity asymmetry for pi(0) production at midrapidity in p plus p collisions at root s=510 GeV

PHENIX measurements are presented for the cross section and double-helicity asymmetry (A(LL)) in inclusive pi(0) production at midrapidity from p + p collisions at root s = 510 GeV from data taken in 2012 and 2013 at the Relativistic Heavy Ion Collider. The next-to-leading-order perturbative-quantum-chromodynamics theory calculation is in excellent agreement with the presented cross section result

Impact of human population density on fire frequency at the global scale

Human impact on wildfires, a major earth system component, remains poorly understood. While local studies have found more fires close to settlements and roads, assimilated charcoal records and analyses of regional fire patterns from remote-sensing observations point to a decline in fire frequency with increasing human population. Here, we present a global analysis using three multi-year satellite-

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI= 30 Kg/m(2)). We performed two case-control genome-wide studies using two accepted cut-offs for defining individuals as overweight

Above-ground and below-ground plant responses to fertilization in two subarctic ecosystems

Soil nutrient supply is likely to change in the Arctic due to altered process rates associated with climate change. Here, we compare the responses of herbaceous tundra and birch forest understory to fertilization, considering both above-and below-ground responses. We added nitrogen and phosphorus to plots in both vegetation types for three years near Abisko, northern Sweden, and measured the effec

Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.

Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation w

Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates

Modification and optimization of the anticancer drug cisplatin is of interest with respect to selective cell targeting and DNA binding efficiency. Attractive approaches contain both, modification of the platinum coordination sphere and design of hybrid molecules of the cisplatin binding moiety including peptide motifs. Peptides with cell penetrating, directing or recognizing properties can be impl

Grazing resistance allows bloom formation and may explain invasion success of Gonyostomum semen

The nuisance alga Gonyostomum semen (Raphidophyceae) has expanded in the Nordic countries during the last decades and can dominate lake phytoplankton communities almost completely. A possible explanation to its dominance could be limited grazing by zooplankton. We investigated the potential grazing pressure on G. semen using an experimental approach supported by field data. We determined the grazi

Usefulness of Species Traits in Predicting Range Shifts.

Information on the ecological traits of species might improve predictions of climate-driven range shifts. However, the usefulness of traits is usually assumed rather than quantified. Here, we present a framework to identify the most informative traits, based on four key range-shift processes: emigration of individuals or propagules away from the natal location; the distance a species can move; est

Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy

Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccinat

Analysis of Protein Dynamics Simulations by a Stochastic Point Process Approach

MD simulations can now explore the complex dynamics of proteins and their associated solvent in atomic detail on a millisecond time scale. Among the phenomena that thereby become amenable to detailed study are intermittent conformational transitions where the protein accesses transient high-energy states' that often play key roles in biology. Here, we present a coherent theoretical framework, base

ELSA and Gaia: Four years of fruitful collaboration

ELSA (European Leadership in Space Astrometry) is a four-year, EU-funded Research Training Network ending in September 2010. It has employed 10 postgraduate students and 5 postdocs for 2-3 years and financed a number of workshops, training events and topical meetings, culminating in the present symposium. The primary goal of ELSA is to train young scientists in the context of the Gaia project whil

Shell Structure of Natural Rubber Particles: Evidence of Chemical Stratification by Electrokinetics and Cryo-TEM

The interfacial structure of natural rubber (NR) colloids is investigated by means of cryogenic transmission electron microscopy (cryo-TEM) and electrokinetics over a broad range of KNO3 electrolyte concentrations (4-300 mM) and pH values (1-8). The asymptotic plateau value reached by NR electrophoretic mobility (mu) in the thin double layer limit supports the presence of a soft (ion- and water-pe

Criterion validity is maintained when items are evaluatively neutralized: Evidence from a full scale FFM-inventory

The original version and an evaluatively neutralized version (with items rephrased to reduce popularity) of a personality inventory were compared. The results revealed A) Similar criterion validity across three different sets of self-rated behaviors, B) Stronger relations to the rated social desirability of criteria for the original version, and C) Less correlation between factors for the neutrali

Origin of the anomalous temperature dependence of coercivity in soft ferromagnets

We report on the origin of the anomalous temperature dependence of coercivity observed in some soft ferromagnets by studying the magnetic and electronic properties of FeZr films doped using ion implantation by H, He, B, C, and N. The anomalous increase of the coercivity with temperature was observed only in the C- and B-doped samples. Using x-ray photoelectron spectroscopy, we show that the anomal

Retinal ganglion cell topography and spatial resolution of two parrot species: budgerigar (Melopsittacus undulatus) and Bourke's parrot (Neopsephotus bourkii).

Retinal ganglion cell (RGC) isodensity maps indicate important regions in an animal's visual field. These maps can also be combined with measures of focal length to estimate the theoretical visual acuity. Here we present the RGC isodensity maps and anatomical spatial resolving power in three budgerigars (Melopsittacus undulatus) and two Bourke's parrots (Neopsephotus bourkii). Because RGCs were st