The amyloid beta (A beta) peptides (mainly A beta 40 and A beta 42), which are derived from the amyloid precursor protein (APP), can oligomerize into antibody A11-positive, neurotoxic species, believed to be involved in Alzheimer's disease. Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells. In

Older people have more functional limitations than younger people and they form a segment of the population that is more dependent on mobility devices than other age groups. Since they spend most of their time at home, their dwelling is an important environmental arena for performing everyday activities. Barriers in the environment can limit or hinder activity performance. Therefore, older people

Background: Early developmental conditions can influence within- and among-brood variation in the timing of hatching/birth, which has been shown to affect offspring survival, growth, and reproductive success across a range of species. Problem: How does within- and among-litter variation in the timing of birth affect offspring growth and survival in Egernia whitii? Organism: Egernia whitii, a l

The formation of chondrules is one of the oldest unsolved mysteries in meteoritics and planet formation. Recently an old idea has been revived: the idea that chondrules form as a result of collisions between planetesimals in which the ejected molten material forms small droplets that solidify to become chondrules. Pre-melting of the planetesimals by radioactive decay of Al-26 would help produce sp

Purpose: To what extent active surveillance and deferred treatment for localized risk prostate cancer are used is unclear. We assessed the use of surveillance and of deferred treatment in a population based, nationwide cohort in Sweden. Materials and Methods: In the National Prostate Cancer Register of Sweden, with a 98% coverage vs the compulsory Swedish Cancer Registry, we identified 8,304 incid

A novel sequential injection method for the determination of nitrite at nanomolar level in seawater samples has been developed. The pink azo compound was formed based on the Griess reaction and quantitatively adsorbed onto a Sep-Pak C18 cartridge. The enriched azo compound was rinsed with water and ethanol (28%, v/v) in turn, and then eluted with an eluent containing 26.6% (v/v) ethanol and 0.108m

A widespread and flexible use of robots in rapidly changing working environments could be greatly enhanced by human-robot interaction and collaboration. Humans and robots have complementary skills. The robotic worker can relieve the human from repetitive work, and the human can make robot deployment easier by managing nonstandard or particularly skilful operations. Such a scenario, however, requir

Background: MicroRNA-34 is a family of three miRNAs that have been reported to function as tumor suppressor miRNAs and show decreased expression in various cancers. Here, we examine functions of miR-34c in basal-like breast cancer cells. Methods: Data from The Cancer Genome Atlas (TCGA) were used for evaluation of expression in primary breast cancers. Cellular processes affected by miR-34c were in

Context: The notion of insignificant prostate cancer (Ins-PCa) has progressively emerged in the past two decades. The clinical relevance of such a definition was based on the fact that low-grade, small-volume, and organ-confined prostate cancer (PCa) may be indolent and unlikely to progress to biologic significance in the absence of treatment. Objective: To review the definition of Ins-PCa, its in

Muscle contraction studies often focus solely on myofibres and the proteins known to be involved in the processes of sarcomere shortening and cross-bridge cycling, but skeletal muscle also comprises a very elaborate ancillary network of capillaries, which not only play a vital role in terms of nutrient delivery and waste product removal, but are also tethered to surrounding fibres by collagen "wir

Cold sensitivity is a common complaint following hand injuries. Our aim was to investigate long-term self-reported cold sensitivity, and its predictors and the importance of sense of coherence (SOC), 8 years after a hand injury as well as in patients treated for Hand Arm Vibration Syndrome (HAVS) during the same time period.

Popular Abstract in Swedish Reglering och kommunikation med störande brus Hur kan man på bästa möjliga sätt skicka data, till exempel en ljudsignal, när kommunikationen störs av brus och ändå måste ske snabbt? Och hur kan man på bästa sätt styra en process när styrsystemet begränsas av dålig kommunikation? Dessa frågor har undersökts i avhandlingen Control and Communication with Signalto-Noise This thesis is about two problems in the intersection of communication and control theory. Their common feature is that they involve communication over an additive white noise channel with a signal-to-noise ratio (SNR) constraint. The first problem concerns the transmission of a real-valued signal from a partially observed Markov source. The distortion criterion is the mean squared error and the

High PHA production and storage using palm oil mill effluent (POME) was investigated using a laboratory batch Bio-PORec (R) system under aerobic-feeding conditions. Results showed that maximum PHA was obtained at a specific rate (q(p)) of 0.343 C-mol/C-mol h when air was supplied at 20 ml/min. The PHA yield was found to be 0.80 C-mol/C-mol acetic acid (HAc) at microaerophilic condition and the mas

The ratio of the production cross sections for W and Z bosons in association with jets has been measured in proton-proton collisions at root s = 7 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is based on the entire 2011 dataset, corresponding to an integrated luminosity of 4.6 fb(-1). Inclusive and differential cross-section ratios for massive vector bosons decaying

Insulin secretion from pancreatic beta-cells is controlled by complex metabolic and energetic changes provoked by exposure to metabolic fuels. Perturbations in these processes lead to impaired insulin secretion, the ultimate cause of T2D (Type 2 diabetes). To increase our understanding of stimulus secretion coupling and metabolic processes potentially involved in the pathogenesis of T2D, a compreh

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Akut inflammation i bukspottskörteln (akut pankreatit, AP) är en vanlig sjukdom som oftast debuterar med kraftiga buksmärtor och ibland illamående och kräkningar. De flesta patienter, ungefär 80%, får en mild form av sjukdomen som begränsas till just bukspottkörteln (pancreas), och dessa patienter tillfrisknar efter några daAcute pancreatitis is an inflammatory disease characterized by a diverse spectrum of clinical presentations ranging from a mild and self-limiting to a severe and systemic disorder. The relationship between inflammation and proteolytic activation in pancreatitis is an elusive issue. The aim of this thesis was to define the influence of platelets and neutrophils as well as their interrelations in re