Background and purpose The Scandinavian Sarcoma Group (SSG) XIV protocol is based on experience from previous SSG trials and other osteosarcoma intergroup trials, and has been considered the best standard of care for patients with extremity localized, non-metastatic osteosarcoma. We analyzed the outcome in 63 consecutive patients. Patients and methods From 2001 through 2005, 63 patients recruited

New tools and forms of cooperation at the landscape level are needed in order for forestry and environmental conservation to co-exist in areas with many land owners. Awareness has existed for several years in Sweden that cooperation at the landscape level is essential for protecting areas of high environmental value. This awareness has come to expression in several projects and initiatives. One of

BACKGROUND: Conversion operations after vertical banded gastroplasty (VBG) are sometimes performed because of vomiting and/or acid regurgitation. Primary operation with gastric bypass (GBP) is known to reduce gastroesophageal reflux (GERD). Previous studies have not been designed to differentiate between the effects of the altered anatomy and of the ensuing weight loss. No series has reported data

Objective . Low density lipoprotein cholesterol (LDL-C) is an independent and modifiable risk factor for development of cardiovascular disease (CVD). Postprandial lipid metabolism has been linked to CVD, but little is known about the postprandial LDL-C profile in patients with type-2 diabetes (T2DM). We aimed to study the postprandial levels of LDL-C in T2DM patients. Material and methods . After

Susceptibility genes and environmental factors are important for development of Type 1 diabetes (T1D). Increased birth weight (BW), increased linear growth and gestational infections are among the reported risk factors. T1D is predictable by analysis of HLA genotypes and islet cell autoantibodies. In this thesis risk factors and prediction of T1D were studied as part of the Diabetes Prediction in

Background: Major intrinsic proteins (MIPs) also named aquaporins form channels facilitating the passive transport of water and other small polar molecules across membranes. MIPs are particularly abundant and diverse in terrestrial plants but little is known about their evolutionary history. In an attempt to investigate the origin of the plant MIP subfamilies, genomes of chlorophyte algae, the sis

We investigate, with high-resolution angle-resolved photoemission spectroscopy, the spectral function of potassium-doped quasi-free-standing graphene on Au. Angle-dependent x-ray photoemission and density functional theory calculations demonstrate that potassium intercalates into the graphene/Au interface, leading to an upshift of the K-derived electronic band above the Fermi level. This empty ban

Background: Many patients with cervical disc disease require leave from work, due to long-lasting, complex symptoms, including chronic pain and reduced levels of physical and psychological function. Surgery on a few segmental levels might be expected to resolve disc-specific pain and reduce neurological deficits, but not the non-specific neck pain and the frequent illness. No study has investigate

We have estimated affinities for the binding of 34 ligands to trypsin and nine guest molecules to three different hosts in the SAMPL3 blind challenge, using the MM/PBSA, MM/GBSA, LIE, continuum LIE, and Glide score methods. For the trypsin challenge, none of the methods were able to accurately predict the experimental results. For the MM/GB(PB)SA and LIE methods, the rankings were essentially rand

Production of synthetic vehicle fuels from biomass is a hot topic. There are several alternative fuels to consider when evaluating properties such as cost of production and energy efficiency to both product and final use in a road vehicle. Thermochemical conversion via gasification and downstream synthesis of fuels as well as biochemical conversion of woody biomass to ethanol is considered in this

A pentose-rich hydrolysate fraction obtained by extraction of steam-pretreated sugarcane bagasse was analysed with regard to dissolved phenolics. The liquid obtained after steam pretreatment (2% SO2 (w/w) at 190 ◦C for 5min)was divided into two parts: one containing dissolved compounds originating from hemicellulose (with xylose as the dominating compound), and the other containing predominantly d

A Monte-Carlo simulation package has been developed to model the response of a detector system for ion identification used in conjunction with ion separators following nuclear reactions. The simulation is written predominantly using the GEANT4 framework but utilises the ion transport code MOCADI for accurate separator and reaction modelling. A novel MOCADI-GEANT4 interface has been developed to ut

Neuronal endoplasmic reticulum (ER), continuous from soma to dendritic spines, undergoes rapid fragmentation in response to N-methyl-D-aspartate (NMDA) receptor stimulation in hippocampal slices and neuronal primary cultures. Here, we show that ER fragments in the mouse brain following cardiac arrest (CA) induced brain ischemia. The ER structure was assessed in vivo in cortical pyramidal neurons i

FLT3 and c-KIT are crucial regulators of hematopoietic stem and progenitor cells. We investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. STS1/STS2-deficient mice show a profound expansion of multipotent progenitor and lymphoid primed multipotent progenitor cells with elevated colony-forming capacity. Although