To acquire a better understanding of clonal evolution of acute myeloid leukemia (AML) and to identify the clone(s) responsible for disease recurrence, we have comparatively studied leukemia-specific mutations by whole-exome-sequencing (WES) of both the leukemia and the nonleukemia compartments derived from the bone marrow of AML patients. The T-lymphocytes, B-lymphocytes and the functionally norma

The industrial relations models among the EU/EES countries vary widely. The Nordic model of self-regulation contrasts sharply to French state extension of collective agreements and minimum wage set by the state. While social dialogue often refers to tripartite negotiations, bipartite collective bargaining is characteristic of self-regulation. Swedish self-regulation is the most far-reaching among

We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem cell compartment. We identify a substate, which at the single cell level coexpresses pluripotent and mesodermal gene expression programmes. Functionally these cells initiate

Soil carbon (C) reservoirs held in forests play a significant role in the global C cycle. However, harvesting natural forests tend to lead to soil C loss, which can be countered by the establishment of plantations after clear cutting. Therefore, there is a need to determine how forest management can affect soil C sequestration. The management of stand density could provide an effective tool to con

Infection of mice and rats with any one of five tested human adenovirus types belonging to groups A and B (types 3, 7, 12, 18 and 31) induced an immunity to the TSTAs of type 12 tumors as detected by the colony inhibition (CI) test. No immunity was found against an adenovirus type 1 tumor. Two adenovirus types belonging to group C (types 1 and 5) were similarly tested and found to induce a clear‐c

It is unclear how pathological aging of the inflammatory system relates to Alzheimer’s disease (AD). We tested whether age-related inflammatory changes in cerebrospinal fluid (CSF) and plasma exist across different stages of AD, and whether such changes related to AD pathology. Linear regression was first used model chronological age in amyloid-β negative, cognitively unimpaired individuals (Aβ− C

Early career scientists sometimes observe senior scientists engage in apparent scientific misconduct, but feel powerless to intervene, lest they imperil their careers. We propose a Secure Reporting Procedure that both protects them, when pursuing those concerns, and treats the senior scientists fairly. The proposed procedure is, we argue, consistent with the ethical principles of the scientific co

From the catalytic, semiconducting, and optical properties of zinc oxide (ZnO) numerous potential applications emerge. For the physical and chemical properties of the surface, under-coordinated atoms often play an important role, necessitating systematic studies of their influence. Here we study the vicinal ZnO(10 1 ¯ 4) surface, rich in under-coordinated sites, using a combination of several expe

In this paper we present the matched window reassignment method, generalizing the results to complex valued signals in multiple dimensions. For an oscillating transient signal with an envelope shape described by an arbitrary twice differentiable function, the reassigned spectrogram, with a matched window, concentrates all energy into one single time-frequency point. An estimator for the parameters

Fetal immobilization affects skeletal development and can lead to severe malformations. Still, how mechanical load affects embryonic bone formation is not fully elucidated. This study combines mechanobiology, image analysis and developmental biology, to investigate the structural effects of muscular loading on embryonic long bones. We present a novel approach involving a semi-automatic workflow, t

Background: Controlled release (CR) systems have emerged as powerful platforms for innovative formulations and dietary designs to enhance the techno-functional performance of bioactive food ingredients both in human body and food products. Generally, the term CR, has developed to indicate delivery systems with optimal control over release rate and performance. However, there are principles and req

For many fleeing their home countries, destinations in northern Europe were the ultimate goal. But what happened when they got there?

I argue that reception history can have a, limited but important, role to play as tie- breaker in the evaluation of reconstructions of historical philosophical arguments and positions. In an effort to exemplify the proposed methodology I argue that Lisa Shapiro’s rational reconstruction of Descartes’s provisional moral code in terms of a broad conception of morality supplies us with an interpretat