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Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

BACKGROUND: The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (AQP4) expression, facilitates much of this brain clearance. During the last decade, several observations hav

Analysis and design of recovery behaviour of autonomous-vehicle avoidance manoeuvres

Autonomous vehicles allow utilisation of new optimal driving approaches that increase vehicle safety by combining optimal all-wheel braking and steering even at the limit of tyre–road friction. One important case is an avoidance manoeuvre that, in previous research, for example, has been approached by different optimisation formulations. An avoidance manoeuvre is typically composed of an evasive p

A technical workforce for regional industrial development? Origin and dispersion of graduates from the technical secondary schools in Malmö and Borås 1855–1930

This article connects to the discussion on skills and knowledge during the early industrialisation. It focuses on how two out of four technical secondary schools in Sweden (Malmö and Borås) lived up to their aims communicated by politicians and other stakeholders: to provide emerging industries and crafts in their regions with technicians and to prepare for studies at the Technological Institute.

Complex Eigenvalue Splitting for the Dirac Operator

We analyze the eigenvalue problem for the semiclassical Dirac (or Zakharov–Shabat) operator on the real line with general analytic potential. We provide Bohr–Sommerfeld quantization conditions near energy levels where the potential exhibits the characteristics of a single or double bump function. From these conditions we infer that near energy levels where the potential (or rather its square) look

Application of lean methods into design process of large power transformers

The paper presents application of lean engineering methods at design process re-engineering. Lean principles are harder to implement in an one-of-a-kind production environment rather than in an environment of a serial production, where there are almost no changes during production process. There are considerable differences in value-added activities that characterize lean production on one hand an

Eco-evolutionary perspectives on emergence, dispersion and dissolution of historical Dutch commons

Historical commons represent self-governed governance regimes that regulate the use and management of natural and man-made shared resources. Despite growing scientific interests, analyses of commons evolution and temporal dynamics are rare and drivers of change (birth, adaptation, dissolution) remain obscure. We apply an interdisciplinary approach and address these issues from an eco-evolutionary

Punishment mechanisms and their effect on cooperation: : A simulation study.

In social dilemmas punishment costs resources, not just from the one who is punished but often also from the punisher and society. Reciprocity on the other side is known to lead to cooperation without the costs of punishment. The questions at hand are whether punishment brings advantages besides its costs, and how its negative side-effects can be reduced to a minimum in an environment populated by

Exact expressions for numerical evaluation of high order modes of vibration in uniform Euler-Bernoulli beams

In the literature, expressions can be found for the mode shape functions of uniform Euler-Bernoulli beams. However, these expressions permit the evaluation of only the first 12 modes or so due to numerical issues associated with the evaluation of near field waves that increase exponentially with frequency. To overcome this problem, approximate expressions have been developed that avoid the evaluat

Performing building vibration assessments by acoustic measurements

This article presents an innovative application of the frequency domain decomposition method based on an acoustic and vibration response. Frequency domain decomposition method has been frequently used for operational modal analysis testing in the last decade to identify modal parameters for in-situ case studies. For these studies, the outputs of the vibration response through accelerometers have b

Time Intervals Under the Lens at Sweden’s First Diagnostic Center for Primary Care Patients With Nonspecific Symptoms of Cancer. A Comparison With Matched Control Patients

Introduction: Fast-track referral pathways for patients with nonspecific, serious symptoms have been implemented in several countries. Our objective was to analyze time intervals in the diagnostic routes of patients diagnosed with cancer at Sweden’s first Diagnostic Center (DC) for nonspecific symptoms and compare with time intervals of matched control patients. Methods: Adult patients with nonspe

Vilken litteratur (o)synliggörs inom romanska språk i svensk högre utbildning och forskning?

Studien kartlägger litteraturämnen i kandidatuppsatser och avhandlingar i romanska språk i Sverige under tidsperioden 2000-2016. Syftet är att belysa olika litteraturers roll och (o)synliggörande i självständiga arbeten. Ansatsen är deskriptiv och ämnar identifiera mönster och tendenser i materialet. Dessa mönster ska ligga till grund för fördjupade studier av områden med utvecklingspotential i de

Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants

BACKGROUND: Preterm infants are susceptible to hyperglycemia and hypoglycemia, conditions which may lead to adverse neurodevelopment. The use of continuous glucose monitoring devices (CGM) might help keeping glucose levels in the normal range, and reduce the need for blood sampling. However, the use of CGM might be associated with harms in the preterm infant. OBJECTIVES: Objective one: to assess t

Lack of participatory effort : On the ethics of communicating urban planning

In all planning processes, including those we label participatory, there are neglected parties. Even when co-produced decisions, equity objectives, or common initiatives are at hand, some actors are likely to be less listened to, or they are never even recognised, hence, ‘perfect’ participation does not exist. Nevertheless, participatory objectives continue to be an important resilience factor in

Heat production in different populations of human blood cells exposed to immune complexes in vitro : The importance of the Fc parts of immunoglobulins and the influence of active complement

By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values