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Since the first derivation of human pluripotent stem cells (hPSCs) 27 years ago, technologies to control their differentiation and manufacturing have advanced immensely, enabling increasing numbers of clinical trials with hPSC-derived products. Here, we revew the landscape of interventional hPSC trials worldwide, highlighting available data on clinical safety and efficacy. As of December 2024, we
Background and Purpose: Although reirradiation of glioblastoma has a long history of clinical practice, guidance on how to perform it in the context of recent technological advances, modern imaging modalities or systemic therapy is scarce. This joint ESTRO/EANO guideline aims to collect the existing evidence to produce recommendations for safe reirradiation of glioblastoma. Methods: The basis of t
We have previously demonstrated that the intracellular, non-GPI anchored CD59 isoforms IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are necessary for insulin secretion from pancreatic β-cells. While investigating their expression across human tissues, we identified IRIS-1 and IRIS-2 mRNA in the human brain, though their protein expression and function remained unclear. This stud
Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum diesel with renewable diesel can alter emission properties but the potential health effects remain unclear. This study aimed to explore toxicity and underlying mechanisms of diesel exhaust from renewable fuels. Using proximity extension assay (Olink), 92 proteins linked to inflam
Background: Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity i
Objectives To investigate the effect of precarious employment (PE) on the risk of diagnosed chronic musculoskeletal disorders (MSDs) among Swedish workers in occupations with strenuous working conditions. Methods This nationwide register-based cohort study included workers registered as living in Sweden in 2005, aged 21-60 at the 2010 baseline. Three samples were included: workers with high biomec
Research shows conversations matter - both for learning and inspiring action. In this podcast collection, we are 'Talking Transformations' with thought leaders from government, industry, and academia. Our mission is to discuss current trends in science, technology, governance, and behaviours to transform our society and economy towards sustainability. In this podcast mini-series, season 2, we talk
This paper considers the ways in which research projects linger beyond their ‘official’ endings, and how to deal with this. Building on conversations in human geography and related disciplines on slow research, performed endings, and the practical and socio-political complexities of data storage and analysis over time, I relate some experiences with my research on the Finnish Saimaa Ringed Seal, w
Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway disease. DNA variants were detected in three families by sequencing. In two unrelated families, a deep-intronic variant (KIAA0586/TALPID3:c.3990 + 3186G>A) act
Aim: To analyse the challenges faced by parents of extremely preterm infants born before 24 weeks of gestation and the potential buffering effect of perceived resources on the family's health continuum. Methods: The qualitative data were obtained from 70 parents of 70 infants born before 24 weeks of gestation, through open-ended questions in a survey. An inductive content analysis was conducted to
Raw sediment samples which are without prior lengthy laboratory preparation can be used to obtain a rough but rapid estimate of the luminescence equivalent dose, and thus of the relative age of the sediment. In this study, we tested this range-finder method on clastic sediments in NE Poland for the first time, with special focus on Pleistocene meltwater sediments generated by highly energetic glac
Nonlinear effects play a central role in photonics as they form the foundation for most of the device functionalities such as amplification and quantum state preparation and detection. Typically the nonlinear effects are weak and emerge only at high photon numbers with strong drive. Here we present an experimental study of a Josephson junction -based high-impedance resonator. We show that by takin
Introduction: Little is known of the long-term prognosis of patients with acute ischaemic stroke in the absence of standard modifiable stroke risk factors (SMoRFs). In acute coronary syndromes, patients without modifiable risk factors have a higher mortality rate. We analysed data from the Swedish Stroke Register to determine survival of patients without SMoRFs following an ischaemic stroke. Patie
InAs nanowires have been used as selectors and electrodes in a one-transistor one-resistor resistive random-access memory (RRAM) configuration for increased memory scalability. Such oxide-based memories not only show promise both in conventional memory technology but also as analog memories for neural networks. The small areas of the oxide elements, however, result in challenges for electrical cha
Background: Desmoplastic melanoma (DM) is a rare subtype, accounting for less than 5% of primary cutaneous invasive melanomas. DM often arises in chronically sun-exposed skin, in older individuals. While the incidence of cutaneous melanoma has increased globally, trends specific to DM are less documented and studies on survival outcomes for DM are inconsistent. Objectives: To study patient and tum
Metal fuels can be promising candidates as alternative energy sources and renewable energy carriers within the metal-fuel cycle. They feature high energy density, low environmental impact, and broad production and application. One challenge in metal particle combustion lies in its multi-physics complexity compared to traditional hydrocarbon fuels. This thesis intends to investigate the combustion
Denna rapport jämför två fall där Helsingborgs stad verkar för att bli mer cirkulär. Det ena är hur avfallsbolaget NSR (där staden är majoritetsägare) har utvecklat en produktionsanläggning och kompetenscentrum om biokol. Det andra är hur Stadsbyggnadskontoret, med Fastighetsförvaltningen, arbetar med att främja återbruk. Rapporten beskriver hur man i dessa två fall har skapat agendasättande relatDenna rapport jämför två fall där Helsingborgs stad verkar för att bli mer cirkulär. Det ena är hur avfallsbolaget NSR (där staden är majoritetsägare) har utvecklat en produktionsanläggning och kompetenscentrum om biokol. Det andra är hur Stadsbyggnadskontoret, med Fastighetsförvaltningen, arbetar med att främja återbruk. Rapporten beskriver hur man i dessa två fall har skapat agendasättande relat
