Thermodynamic stability of an alkaline protease from a new alkaliphilic Nesterenkonia sp. AL-20, was investigated and compared with that of Subtilisin Carlsberg. The amount of calcium bound to the AL-20 protease was determined to be only about 0.14 mol/mol of protease. Differential scanning calorimetry scan of the enzyme at increasing temperature showed the denaturation of the enzyme to be a two-s

We have studied the influence of a wide concentration range of islet amyloid polypeptide (IAPP) on both glucagon and insulin release stimulated by various types of secretagogues. In an islet incubation medium devoid of glucose, the rate of glucagon release being high, we observed a marked suppressive action by low concentrations of IAPP, 10−10 and 10−8 M, on glucagon release. Similarly, glucagon r

We report the first measurements of z -dependent coherent optical transition radiation (COTR) due to electron-beam microbunching at high gains (>10(4) ) including saturation of a self-amplified spontaneous emission free-electron laser (FEL). In these experiments the fundamental wavelength was near 530 nm, and the COTR spectra exhibit the transition from simple spectra to complex spectra (5% spectr

Truncating germline mutations in the tumor suppressor gene BRCA-1 associated protein-1 (BAP1) have been reported in families predisposed to developing a wide range of different cancer types including uveal melanoma and cutaneous melanoma. There has also been an association between amelanotic tumor development and germline BAP1 mutation suggesting a possible phenotypic characteristic of BAP1 mutati

By mimicking embryonic development of the hematopoietic system, we have developed an optimized in vitro differentiation protocol for the generation of precursors of hematopoietic lineages and primitive hematopoietic cells from human embryonic stem cells (ES) and induced pluripotent stem cells (iPS). Factors such as cytokines, extra cellular matrix components, and small molecules, as well as the te

The title compound, cis-[Pt(CH3COO)2(C2H6S)2], crystallizes in the P21/c space group with a pseudo-square-planar geometry. The complex forms centrosymmetric dimeric packing units, with C-H...O-Pt interactions and a short Pt...Pt distance [3.5868(2) Å]. The coordination mode of the acetate ligands is monodentate and they are oriented almost perpendicular to the coordination plane. Cambridge Structu

This paper takes an initial step in integrating insights from two sets of literature which have focused on central aspects of development with unfortunate independence. It highlights politically valuable resources, which are identified in the political economy literature, and shows that the informal sector literature provides ample evidence that these resources in general are (i) scarcely availabl

This paper treats 12 Candelariella species occurring in western North America characterized by having lecanorine apothecia and 8-spored asci. Six new names are proposed: C. aggregata, C. californica, C. complanata, C. corallizoides, C. deppeanae and C. inmarginata. Candelariella terrigena and C. deflexa are treated as synonyms of C. citrina and C. aurella, respectively. Candelariella kansuensis is

Currently, the mechanism by which anesthesia occurs is thought to involve the direct binding of inhaled anesthetics to ligand-gated ion channels. This hypothesis is being studied using four--helix bundles as model systems for the transmembrane domains of the natural "receptor" proteins. This study concerns the role in anesthetic binding played by aromatic side chains in the binding cavity of a fou

In this prospective study, the 10- and 15-year incidence and course of retinopathy were examined in relation to medical risk indicators from 3.1 +/- 1.9 (mean -/+ SD) years diabetes duration and onwards in 29 adult type 1 diabetic patients treated under routine care. A total of 28 patients were followed for 10 years and 20 patients for 15 years diabetes duration. After 10 years diabetes duration,

Real-time PCR technology is increasingly used for detection and quantification of pathogens in food samples. A main disadvantage of nucleic acid detection is the inability to distinguish between signals originating from viable cells and DNA released from dead cells. In order to gain knowledge concerning risks of false-positive results due to detection of DNA originating from dead cells, quantitati

The authors propose a new algorithm, "local K" (LK), for fast evaluation of the exchange Fock matrix in case the Cholesky decomposition of the electron repulsion integrals is used. The novelty lies in the fact that rigorous upper bounds to the contribution from each occupied orbital to the exchange Fock matrix are employed. By formulating these inequalities in terms of localized orbitals, the scal

When an excess of human cystatin C or chicken cystatin was mixed with papain, an enzyme-inhibitor complex was formed immediately. The residual free cystatin was then progressively converted to a form with different electrophoretic mobility and chromatographic properties. The modified cystatins were isolated and sequenced, showing that there had been cleavage of a single peptide bond in each molecu

The Price of Democracy and the Value of Literature : Books, Politics, and the Literary Market with Respect to the 2002 Reduction in VAT on Books in Sweden In 2002 the VAT (value added tax) on books in Sweden was reduced from 25% to 6 %. The reduction was effected in response to a cultural policy, whose aim was to ”improve the conditions for literature and reading” and ”stimulate a diversifed out

We present calculations of elliptic flow and azimuthal dependence of correlation radii in the ellipsoidally symmetric generalization of the Buda-Lund hydrodynamic model of hadron production in high-energy nuclear collisions. We compare them to data from RHIC by simultaneous fits to azimuthally integrated invariant spectra of pions, kaons and protons-antiprotons measured by PHENIX in Au + Au reacti

Popular Abstract in Swedish Personlighetspsykologer har i mer än ett århundrade försökt att identifiera och beskriva observerbara skillnader mellan individer. Bland dessa indiduella skillnader har intelligens och personlighet fått stor uppmärksamhet inom skolvärlden, liksom elevers förhållningssätt till sitt lärande. Kunskapen om vilka faktorer som påverkar studieresultat har viktiga praktiska konThe aim of the present doctoral thesis was to examine to what extent personality traits and approaches to learning contribute to academic performance in upper secondary school (high school), after controlling for the well-known fact that general intelligence accounts for a large part of the variance. The general proposition of the thesis is that personality traits are stable dispositons and theref

Background: Empowerment is essential for gender equity and health. The city of Malmö, Sweden, has formulated a development plan for gender equity integration (GEIDP). A 'Policy Empowerment Index' (PEI) was previously developed to assess the empowerment potential of policies. Objectives: To pilot-evaluate the GEIDP's potential for empowerment and to test the PEI for future policy evaluations. Desig

The aim of this single-site, open-label clinical trial was to determine the biodistribution, pharmacokinetics, absorbed doses, and safety from 2 sequential weight-based administrations of Ra-223-dichloride in patients with bone metastases due to castration-refractory prostate cancer. Methods: Six patients received 2 intravenous injections of Ra-223-dichloride, 6 wk apart, at 100 kBq/kg of whole-bo