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Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI

Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) biomarkers. We selected 153 subjects with mild cognitive impairment from a multicenter memory clinic-based cohort. We tested the CSF beta amyloid (A beta)1-42/tau ratio u

Crisis, austerity and opposition in mainstream media discourses of Greece

This article analyzes neoliberal articulations of the economic crisis in Greece, as they appear at the Ekathimerini daily. Neoliberalism is primarily understood as the ideology organizing the political strategies of late capitalist production. The analysis focuses on the ways the capitalist crisis is presented in the context of Greece, as well as the ways that socio-political opposition to neolibe

A model-supported participatory process for nutrient management: a socio-legal analysis of a bottom-up implementation of the EU Water Framework Directive

A methodology for local stakeholders' involvement in water management using a catchment model as a platform for dialogue has been developed and tested in the Kaggebo Bay drainage area in the southeast of Sweden. The process involved farmers, rural households not connected to municipal wastewater treatment facilities, local and regional authorities as well as different water and agricultural expert

Temperature Aware Power Allocation: An Optimization Framework and Case Studies

In this paper we propose a general power model along with a versatile optimization methodology that can be applied to different applications for minimizing service delay while satisfying power budget in data centers. We test our methodology on two totally different applications from both cloud computing and enterprise scenarios. Our solution is novel in that it takes into account the dependencies

The Evolution of Respiratory Chain Complex I from a Smaller Last Common Ancestor Consisting of 11 Protein Subunits.

The NADH:quinone oxidoreductase (complex I) has evolved from a combination of smaller functional building blocks. Chloroplasts and cyanobacteria contain a complex I-like enzyme having only 11 subunits. This enzyme lacks the N-module which harbors the NADH binding site and the flavin and iron-sulfur cluster prosthetic groups. A complex I-homologous enzyme found in some archaea contains an F(420) de

Coronary Heart Disease in Systemic Lupus Erythematosus Is Associated With Interferon Regulatory Factor-8 Gene Variants

Background- Patients with systemic lupus erythematosus have increased morbidity and mortality in coronary heart disease (CHD). We asked whether there was a genetic influence on CHD in systemic lupus erythematosus. Methods and Results- The association between single-nucleotide polymorphisms (SNPs) and CHD in 2 populations of patients with systemic lupus erythematosus was assessed. Patients were gen

On the volume average of energy and net power

This paper presents an analysis of volume average relations in connection with internal energy, net power and the balance of energy in continuum mechanics. The role of the so-called Hill and Hill-Mandel conditions in connection with the averaged energy balance equation has been elucidated. The significance of volume averages of stress moments for the calculation of the average net power is demonst

Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up: the Malmö Diet and Cancer study.

Arterial stiffness plays a fundamental role in the development of hypertension and is a risk factor for both cardiovascular disease and mortality. The stiffening that occurs with increasing age has, in numerous cross-sectional studies, been shown to be associated with several cardiovascular risk factors. This observational study aims to characterize the predictive and cross-sectional markers focus

Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature

To assess the sensitivity and false positive rate (FPR) of neurological examination and somatosensory evoked potentials (SSEPs) to predict poor outcome in adult patients treated with therapeutic hypothermia after cardiopulmonary resuscitation (CPR). MEDLINE and EMBASE were searched for cohort studies describing the association of clinical neurological examination or SSEPs after return of spontaneo

Novel Loci Associated With PR Interval in a Genome-Wide Association Study of 10 African American Cohorts

Background-The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have exami

Common genetic risk factors for coronary artery disease: new opportunities for prevention?

Atherosclerotic cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide, with coronary artery disease (CAD) being the single leading cause of death. Better control of risk factors, enhanced diagnostic techniques and improved medical therapies have all substantially decreased the mortality of CAD in developed countries. However, CAD and other forms of atherosclerotic CV

Discerning secluded sector gauge structures

New fundamental particles, charged under new gauge groups and only weakly coupled to the standard sector, could exist at fairly low energy scales. In this article we study a selection of such models, where the secluded group either contains a softly broken U(1) or an unbroken SU(N). In the Abelian case new gamma(v) gauge bosons can be radiated off and decay back into visible particles. In the non-

Functional results after orthotopic bladder substitution: A prospective multicentre study comparing four types of neobladder

Objective. The aim of this study was to evaluate enterocystometry, voiding pattern and urine leakage of four types of orthotopic bladder substitute. Material and methods. At eight urological departments, 78 consecutive men were studied: 66 with an ileal neobladder [30 Studer pouches (S), 24 Hautmann pouches (H) and 12 T-pouches (T)] and 12 with a right colonic [Goldwasser type (G)] neobladder. Ent

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.

The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering from Alzheimer's disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal region, yet they display markedly different aggregation behavior. The origins of these differences have remained challenging to connect to specific molecular-level processes underlying the aggregation reaction. In this

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke.

Ischemic stroke induces migration of newly formed neuroblasts, generated by neural stem cells in the adult rat subventricular zone (SVZ), towards the injured striatum where they differentiate into mature neurons. Stroke also leads to accumulation of microglia in the SVZ but their role for neurogenesis is unclear. Here we developed a method for selective depletion of the macrophage antigen complex-

Two-dimensional acoustic particle focusing enables sheathless chip Coulter counter with planar electrode configuration.

The field of cytometry has grown in scope and importance ever since the early 20th century with leaps in technology introducing the Coulter counter and the flow cytometer. Cytometry methods have brought about a revolution for the medical and biotechnology industry by providing fast and accurate analysis of cell and particle suspensions. Recent developments in the field aim at improving current cyt

Social structures in the operating theatre: how contradicting rationalities and trust affect work.

Aim. This article is a report of a study of how healthcare professionals involved in surgery orientate themselves to their common task, and how this orientation can be affected by the social and organizational context. Background. Previous research indicates that surgical teams are not as cohesive as could be expected and that communication failures frequently occur. However, little is known abo