Exploring the effects of platinum compounds on RNA, adduct formation, thermal melting properties and siRNA down regulation capacity of gene targets associated
Since its discovery, RNA interference (RNAi) has turned into an invaluable research tool for regulating gene expression. Furthermore, this naturally occurring phenomenon in mammalian cells is of interest in cancer research, both as a possible therapeutic approach and a target for cancer treatment. Platinum anticancer agents like cisplatin are considered one of the most active cancer drugs used eit