Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

This paper presents a joint experimental and large eddy simulation (LES) study of lean premixed low swirl stabilized methane/air flames at different Reynolds numbers (Re similar to 20,000-100,000). The aims are to investigate the sensitivity of the structures and dynamics of low swirl flames to the inflow boundary conditions and to evaluate the capability of an LES flamelet model in predicting the

Background: Voltage-dependent K+ channels (Kv) mediate repolarisation of beta-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K+ channel in this process is however unclear. We tested for presence of Kv1.1 in different species and tested for a functional role of Kv1.1 by assessing pancreatic islet function in BALB/cByJ (wild-type) and megencephaly (mceph/mceph)

Poly(arylene ether sulfone)s carrying various aromatic mono-, di-, and trisulfonated side´chains have been investigated with respect to their nanoscale structure and key membrane properties. Sulfobenzoyl, sulfonaphthoxybenzoyl, disulfonaphthoxybenzoyl, and trisulfopyrenoxybenzoyl side chains were attached to the poly(arylene ether sulfone) main chain by employing different combinations of metallat

Osteoporosis and low bone strength in older people may be due to low bone mass accrual or elevated age-related loss of bone mass. The mechanisms underlying loss of bone mass have long been subjected to research. However, research has only started in the last decade to focus on strategies to increase bone mass:the current opinion is that childhood and adolescence are critical periods for building u

A search for microscopic black holes has been performed in a same-sign dimuon final state using 1.3 fb(-1) of proton-proton collision data collected with the ATLAS detector at a centre of mass energy of 7 TeV at the CERN Large Hadron Collider. The data are found to be consistent with the expectation from the Standard Model and the results are used to derive exclusion contours in the context of a l

Background: Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken Gallus gallus, the avian species with the best characterized MHC, possesses a highly streamlined minimal essential MHC, which is linked to resis

The concept of followership in higher education has been given limited attention despite the fact that followers are key players in the follower/leader equation and that leadership is increasingly seen as vital to improving the student learning experience. This paper explores this concept, reporting on the findings of a qualitative study underpinned by a socio-constructivist framework. Thirty-eigh

Although diabetes is one of the most serious global health problems, there is no real cure yet for it. The conventional insulin treatment programs aimed at life quality improvement do not take into account the psychological aspects of the disease. Because diabetes has important psychological components, it seems reasonable to consider hypnosis as an adjunct therapy for diabetes. This paper examine

This review summarizes recent progress in our understanding of aquoeus "complex salts" of ionic surfactants with polymeric counterions. Complex salts are simplified versions of the much-studied mixtures of oppositely charged polyelectrolytes and surfactants, and are also good model systems to study the fundamentals of polyion-mediated forces in colloidal systems. Comparisons are made with conventi

Manufacturing corporations sometimes use corporate-internal procedures to evaluate and monitor the ergonomic status of the workplace. This article describes an industrial case study in the Swedish automotive sector, where an internally developed evaluation procedure was compared with a procedure based on a Swedish national standard provision. It was found that the national standard procedure tende

Background: Women working in the public human service sector in 'overstrained' situations run the risk of musculoskeletal symptoms and long-term sick leave. In order to maintain the level of health and work ability and strengthen the potential resources for health, it is important that employees gain greater control over decisions and actions affecting their health - a process associated with the

Abstract in Undetermined This article explores the potential of video activism on YouTube to form a communicative space for deliberation and dissent. It asks how commenting on activist videos can help sustain civic cultures that allow for both antagonism and inclusive political debate.

Objective: The objective of this study was to compare the outcomes of antiretroviral therapy (ART) between hospital and health center levels in Ethiopia. METHODS: Medical records of 1709 ART patients followed for 24 months at 2 hospitals and 3 health centers in the Oromia region of Ethiopia were reviewed. Noted outcomes of ART were currently alive and on treatment; lost to follow-up (LTFU); transf

Popular Abstract in Swedish Avsaltning av havsvatten utgör en viktig källa för vattenförsörjning till befolkningen som bor vid Persiska viken, Medelhavet och Röda havet. De tre regionerna utgör ca 11,8 % av världens landyta och hade omkring 9 % av världens befolkning under 1950 och 2008, samt lika mycket enligt prognos för år 2050. Dessa områden är hemvist för 62 %, 58% och 60% av världens avsaltnSeawater desalination constitutes an important water supply to the population bordering the Arabian Gulf, the Mediterranean Sea and the Red Sea. The three regions represent about 11.8% of the world land area and the countrieshosted approximately 9% of the world population in 1950 and 2008 and are also projected to do so in 2050. The results obtained for desalination capacity in the study area were