In Alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with Brodmann area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and acro

This PhD project balances an interest in social work and its prospects for deliv-ering emancipation or relief from stigma, etc. through motivational agency, on the one hand, with an attentiveness to recent developments in Scandinavian criminal policy, on the other. In my attempts at »bridging« these interests I have come to focus on offender rehabilitation. In this short paper I shall present the

Purpose: Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [18F]flortaucipir PET in relation to cognition may help explain these differences between EOAD and LOAD. Methods: Seventy-nine amyloid-positive individuals with a cl

The clinical utility of microfluidic techniques is often hampered by an unsatisfying sample throughput. Here, the effect of inertial forces on acoustofluidic particle sorting at high sample throughputs is investigated experimentally and theoretically. Polystyrene particles are acoustically prefocused to obtain precise trajectories. At increased flow rates it is observed that the particle stream is

This issue celebrates 20 years of ephemera. We, the editorial collective, feel this anniversary provides the opportunity to debate the pasts, presents and futures of critical publishing. Today, most academic journals are owned by commercial publishing houses and organized according to journal rankings and impact factors. Yet ephemera remains stubbornly independent of these global capitalist forces

The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in tumor biobanks and available at hospital pathology departments. In our retrospective biobank pilot study, 90 FFPE sa

Changes in forest cover have a strong effect on climate through the alteration of surface biogeophysical and biogeochemical properties that affect energy, water and carbon exchange with the atmosphere. To quantify biogeophysical and biogeochemical effects of deforestation in a consistent setup, nine Earth system models (ESMs) carried out an idealized experiment in the framework of the Coupled Mode

Background: Approximately 50% of all patients undergoing esophagectomy experience complications. This paper estimates the costs due to complications after esophagectomy in a Swedish context. Material and methods: The Swedish National Register for Esophageal and Gastric Cancer (NREV) and the Healthcare Consumption Register in Region Skåne (RSVD) were crossmatched for patients undergoing esophagecto

This study presents the results from a set of 11 large-scale open fire tests performed on flexible polyurethane foam slabs/mattresses. The purpose of the study was to investigate the influence of the ignition location on the fire behaviour of the foam slabs and to generate data on a highly characterised material that could be used for modelling work in the future. A method for obtaining spatially

Here we show that scratch family transcriptional repressor 1 (SCRT1), a zinc finger transcriptional regulator, is a novel regulator of beta cell function. SCRT1 was found to be expressed in beta cells in rodent and human islets. In human islets, expression of SCRT1 correlated with insulin secretion capacity and the expression of the insulin (INS) gene. Furthermore, SCRT1 mRNA expression was lower

Importance Perforated colonic diverticulitis usually requires surgical resection, with significant morbidity. Short-term results from randomized clinical trials have indicated that laparoscopic lavage is a feasible alternative to resection. However, it appears that no long-term results are available. Objective To compare long-term (5-year) outcomes of laparoscopic peritoneal lavage and primary re

This paper reports on the quantitative 2D and 3D droplet sizing based on the LIF/Mie ratio in ethanol DISI (Direct Injection Spark Ignition) sprays, where the required calibration is performed using quantitative micro and macro LIF/Mie ratio imaging of individual microdroplets. The droplets are generated from a monodisperse droplet generator in a diameter range from 16 µm to 60 µm. First, the liqu