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Bioethical considerations for human nutrigenomics

This article gives an overview of the ethical issues in nutrigenomics; research and personalized nutrition. The principles of research ethics, i.e., autonomy, beneficence, nonmalfeasance, and justice, are challenged by rapidly growing cross-border research activities utilizing existing and upcoming biobanks for studies of the interaction of genes with diet on risk of common diseases. We highlight

Free volume changes, crystallization, and crystal transition behavior of syndiotactic polystyrene in supercritical CO2 revealed by positron annihilation lifetime spectroscopy

The free volume of syndiotactic polystyrene (sPS) conditioned in supercritical CO2 was investigated by using positron annihilation lifetime spectroscopy (PALS). Supercritical CO2 increased the free volume cavity size of amorphous sPS and made the formation of gamma crystal occur. The orthopositronium (o-Ps) intensity I-3 was correlated well with the crystallinity of gamma form sPS, revealed by its

Hyaluronan reflects the pre-fibrotic inflammation in irradiated rat lung: concomitant analysis of parenchymal tissues and bronchoalveolar lavage

The pathogenesis of pulmonary fibrosis is a complicated chain of interactions between cells and molecules. During recent years bronchoalveolar lavage (BAL) in patients with various interstitial lung disorders has increased our knowledge of the fibrosis process and focused on new interesting interactions. Here we present an animal model which makes it possible to apply both morphological and immuno

Radiological investigation of neurofibromatosis type 2

The radiological findings in six patients fulfilling the criteria of neurofibromatosis type 2 (NF2) were reviewed. Subtle cutaneous lesions were found in three. All patients had bilateral acoustic schwannomas; two had small acoustic tumours and normal hearing. In these patients the presenting symptoms were caused by multiple intracranial meningiomas and spinal neurofibromas, respectively, whereas

Memories of real-life decisions

Three studies investigated decision makers' memory representations of choice alternatives in most important real-life decisions. In Study 1, each participant recalled the most important decision that she or he had ever made and rated to what degree a number of characteristics could describe the decisions. In Study 2, the participants were asked to think about an important decision that they had ma

Observations on reproductive health programs in the baltic States.

Public attention in Sweden has been drawn to three neighboring states that recently joined the European Union: Estonia, Latvia, and Lithuania. At this historic moment, it seems instructive to look at how the rapidly reformed health sectors of these ex-Soviet republics are responding to the vision of reproductive health articulated in Cairo 10 years ago. Reproductive health and rights have improved

Nanoimprint technology for fabrication of three-terminal ballistic junction devices in GaInAs/InP

We present processing technology based on nanoimprint lithography (NIL) and wet etching for fabrication of GaInAs/InP three-terminal ballistic junction (TBJ) devices. To transfer sub-100 nm features into a high-mobility InP-based 2DEG material, we used SiO2/Si stamps made with electron beam lithography and reactive ion etching. After the NIL, the resist residues are removed in oxygen plasma follow

The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans

Type II collagen (CII) is a target for autoreactive T cells in both rheumatoid arthritis and the murine model collagen-induced arthritis. The determinant core of CII has been identified as CII260-270, and the alteration of this T cell epitope by posttranslational modifications is known to be critical for development of arthritis in mice. Using CII-specific T cell hybridomas we have now shown that

Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

Objective: Fasting insulin concentrations are often used as a surrogate measure or insulin resistance. We investigated the relative contributions Of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic. overall h

The international cooperative test of the critical degree of saturation method of assessing the freeze/thaw resistance of concrete

The article describes the execution and result of an investigation of the "'ScR-method'" of freeze/thaw-testing concrete. The investigation formed part of the work within RILEM Committee 4-CDC. Five laboratories participated. Two concrete types were tested," one without and one with entrained air. At each laboratory the critical degree of saturation, SCR, was determined by freeze/thaw-experiments

The origin of x-ray luminescence from CdTe nanoparticles in CdTe/BaFBr : Eu2+ nanocomposite phosphors

X-ray luminescence from CdTe nanoparticles is observed when CdTe nanoparticles are encapsulated into BaFBr:Eu2+ phosphors. In contrast, negligible x-ray luminescence is observed from the unencapsulated nanoparticles, either in solution or in solid form. The origin of the x-ray luminescence is attributed to the effective energy transfer from Eu2+ ions to CdTe nanoparticles in the nanocomposite mate

Guided wave approach for concrete pavement thickness estimation

The basis of a new non-destructive method for concrete pavements is described. The method uses a hybrid approach that combines frequency domain (impact-echo) and time domain (seismic) data. The equipment and data interpretation for the hybrid approach are described. The dynamic response data are interpreted in terms of guided plate wave (Lamb wave) theory, which are shown to follow the S, Lamb mod

Effects of elastic unloading on multiple necking in tensile bars

The deformation of round tensile bars subject to dynamic loading is studied numerically using two different plasticity theories: J(2)-flow theory and J(2)-deformation theory. Time development of neck localization is visualized and a comparison of the necking patterns obtained using the two different constitutive models is presented. The possibility of using J(2)-deformation theory as an alternativ

Collagen type II-specific monoclonal antibody-induced arthritis in mice - Description of the disease and the influence of age, sex, and genes

Transfer of collagen type H (CH)-specific monoclonal antibodies induces an acute form of arthritis (collagen type H antibody-induced arthritis, CAIA) in nave mice. Arthritis was induced using a pair of monoclonal antibodies M2139 and CIIC1, binding to J1 and C1(I) epitopes of CH, respectively. Thereafter, lipopolysaccharide injection was used to increase the incidence and severity of the disease.