The prevalence of type 2 diabetes (T2D) is increasing worldwide, but current treatments have limitations. miRNAs may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D is associated with altered expression and DNA methylation of miRNAs using adipose tissue from 14 monozygotic twin pairs discordant for T2D. Four members each of the miR-30

The role of African-Caribbean nannies in European households is a painful chapter in Caribbean history for many reasons. Ann M. Beaudhuy was a nanny in Christiansted, St. Croix in what was then the Danish West Indies and which is now the US Virgin Islands. In 1871 she wrote letters that have survived time, transfer and geographical displacement. They contain a rare, personal account of the life an

Climate change threatens tropical coastal communities and ecosystems. Governments, resource managers, and communities recognize the value of assessing the social and ecological impacts of climate change, but there is little consensus on the most effective framework to support vulnerability and adaptation assessments. The framework presented in this research is based on a gap analysis developed fro

Lung endothelial cell dysfunction plays a central role in septic-induced lung injury. We hypothesized that endothelial cell subsets, capillary endothelial cells (capEC) and post capillary venules (PCV), might play different roles in regulating important pathophysiology in sepsis. In order to reveal global transcriptomic changes in endothelial cell subsets during sepsis, we induced sepsis in C57BL/

Knowledge remains limited on how the structure of microbial community in paddy soils changes in relation to different types of fertilizers with same amount of nutrients. Thus, here, soil samples were collected at 0–10, 10–20, 20–30, and 30–40 cm depths from a paddy field subjected to four long-term fertilization treatments (no fertilization, mineral fertilization, mineral fertilization combined wi

Microorganisms are important sources of diverse intracellular and extracellular biopolymers havingdifferent functions such as serving as carbon and energy reserves, or as protective layers around the cells in theform of capsules and/or biofilms. They have also found use in foods, medicine and other industrial applications.Research on understanding the synthesis of several biopolymers as well as th

This doctoral thesis explores the effects of carbohydrate(CHO)-restricted diets on symptoms and disease-related variables in type 2 diabetes mellitus (T2DM) and the irritable bowel syndrome (IBS). Aims were to examine the effects of (I) the moderately-low CHO Okinawan-based Nordic diet on anthropometry and metabolism and microbiota-related, inflammatory, and cognitive parameters in T2DM, and (II)

Emotions have traditionally been considered the enemy of reason in Social Science. However, emotions can both enhance and hinder learning in Social Science. It is therefore important to reflect upon why and how emotions play a role, rather than shutting the emotions out or leaving them unreflected in the teaching. This paper draws on ethnographic data from Social Science teaching in four Swedish u

Insects have evolved diverse and remarkable strategies for navigating in various ecologies all over the world. Regardless of species, insects share the presence of a group of morphologically conserved neuropils known collectively as the central complex (CX). The CX is a navigational center, involved in sensory integration and coordinated motor activity. Despite the fact that our understanding of n

Insect neuroscience generates vast amounts of highly diverse data, of which only a small fraction are findable, accessible and reusable. To promote an open data culture, we have therefore developed the InsectBrainDatabase (IBdb), a free online platform for insect neuroanatomical and functional data. The IBdb facilitates biological insight by enabling effective cross-species comparisons, by linking

The solubility and behavior of iron (Fe) in natural waters is tightly linked to Fe speciation, and Fe speciation likely influences how Fe distributes between the water column and sediments. In this study, the function of a lake as an Fe sink, with focus on the role of Fe speciation, was assessed for Lake Bolmen in southern Sweden. We found that a large fraction of the Fe flowing in to the lake was

Background: Evolutionary processes can cause strong spatial genetic signatures, such as local loss of genetic diversity, or conflicting histories from mitochondrial versus nuclear markers. Investigating these genetic patterns is important, as they may reveal obscured processes and players. The maternally inherited bacterium Wolbachia is among the most widespread symbionts in insects. Wolbachia typ

Soil moisture is one of the most important factors controlling the activity and diversity of soil microorganisms. Soils exposed to pronounced cycles of drying and rewetting (D/RW) exhibit disconnected patterns in microbial growth and respiration at RW. These patterns differ depending on the preceding soil moisture history, leading to contrasting amounts of carbon retained in the soil as biomass ve

More than 50% of global lakes periodically freeze, and their lake ice phenology is sensitive to climate change. However, spatially detailed quantification of the changes in lake ice at the global scale is not available. Here, we map ice cover in >33,000 lakes throughout the North Temperate Zone (23.5°–66.5°N) using 0.55 million Landsat images from 1985 to 2020. Over this period, we found a remarka

Microscopy and particle-based simulations are both powerful techniques to study aggregated particulate matter such as colloidal gels. The data provided by these techniques often contains information on a wide array of length scales, but structural analysis methods typically focus on the local particle arrangement, even though the data also contains information about the particle network on the mes