As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF2 source for the construction of gem-difluorinated ring structures. Here, we develop a protocol for the efficient assembly of valuable fluorinated 2,3-dihydrobenzofurans from the [4 + 1] annulation in good yields under basic conditions. The reliable practicabil

How do humans construct their mental representations of the passage of time? The universalist account claims that abstract concepts like time are universal across humans. In contrast, the linguistic relativity hypothesis holds that speakers of different languages represent duration differently. The precise impact of language on duration representation is, however, unknown. Here, we show that langu

Background: A pre-existing, well-established European influenza surveillance network known as I-MOVE enabled the rapid implementation of a European multi-country COVID-19 hospital surveillance network for surveillance of hospitalized COVID-19 cases in early 2020. This network included 257 hospitals in 11 surveillance sites across nine countries. We aimed to identify whether the surveillance object

The possibility of engineering artificial Kitaev chains in arrays of quantum dots coupled via narrow superconducting regions has emerged as an attractive way to overcome the disorder issues that complicate the realization and detection of topological superconducting phases in other platforms. Although a true topological phase would require long chains, a two-site chain realized in a double quantum

Patients who initially survive the rupture and repair of a brain aneurysm often take a devastating turn for the worse some days later and die or suffer permanent neurologic deficits. This catastrophic sequela is attributed to a delayed phase of global cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH), but we lack effective treatment. Here we present our view, based on 20

Considerable progress has been made in the field of leadership in recent years. However, we argue that this is undermined by a strong residual commitment to an older set of ideas which have been repeatedly debunked but which nevertheless resolutely refuse to die. These, we term zombie leadership. Zombie leadership lives on not because it has empirical support but because it flatters and appeals to

Comprehensive sexuality education (CSE) is seen as a key instrument through which to affect behaviour and improve sexual and reproductive health (SRH) outcomes amongst adolescents. However, few studies have to date evaluated key SRH outcomes following exposure to CSE within a school setting. This study estimates the association between CSE and HIV testing and HIV testing self-efficacy amongst HIV

OBJECTIVE: To describe midwives' experiences of intact cord resuscitation close to the mother for nonvigorous neonates after vaginal birth.DESIGN: Descriptive qualitative.SETTING: Four labor wards in Sweden.PARTICIPANTS: Midwives (N = 13) currently or previously employed in labor wards where the Sustained Cord Circulation and Ventilation (SAVE) study was conducted.METHODS: We analyzed semistructur

Background: Well-established associations exist between the risk of small for gestational age (SGA) and unidimensional sociodemographic factors. We investigated social inequalities in SGA risk and adopted an intersectional approach that simultaneously considers different social categories. By doing so, we could assess heterogeneities in SGA risk within unidimensional sociodemographic categories. M

OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).DESIGN: Blood samples from 551 Swedish chil

Vegetation productivity is a critical indicator of global ecosystem health and is impacted by human activities and climate change. A wide range of optical sensing platforms, from ground-based to airborne and satellite, provide spatially continuous information on terrestrial vegetation status and functioning. As optical Earth observation (EO) data are usually routinely acquired, vegetation can be m

Aims Our primary aim was to assess reoperation-free survival at one year after the index injury in patients aged ≥ 75 years treated with internal fixation (IF) or arthroplasty for undis-placed femoral neck fractures (uFNFs). Secondary outcomes were reoperations and mortality analyzed separately. Methods We retrieved data on all patients aged ≥ 75 years with an uFNF registered in the Swedish Fractu

Population ageing within Europe has major social and economic consequences. One of the most devastating conditions that predominantly affects older people is dementia. The SMART4MD (Support Monitoring and Reminder Technology for Mild Dementia) project aims to develop and test a health application specifically designed for people with mild dementia. The aim of this feasibility study was to evaluate

Key messages▶ In the United Nations Framework Convention on Climate Change (UNFCCC), loss and damage has emerged as a third key pillar of climate policy, alongside mitigation and adaptation, to address ever-increasing climate impacts in developing countries that are particularly vulnerable to the adverse effect of climate change. ▶ Losses and damages arise when efforts to avoid or minimize climate

Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity). This has important ecological consequences, because reproduction is the ultimate measure of population fitness: a reduction in reproductive output lowers the population grow

This study analyzes the thermal performance of an indirect-type solar dryer incorporated with a heat exchanger to recover heat from the exhaust. Data were recorded for 8 h from 9:00 to 17:00 from November to January to determine the drying rate for varying airflows from 2 l/s to 12 l/s under the weather conditions of Nepal and Bhutan. The air temperatures in multiple locations in the dryer were re

Introduction: Sport-related concussions (SRC) have been a concern in all sports, including soccer. The long-term effects of soccer-related head injuries are a public health concern. The Concussion in Sport Group (CISG) released a consensus statement in 2017 and several soccer governing associations have published their own SRC guidelines while referring to it but it is unclear whether this has bee

Introduction: Emergent mental illness during adolescence affects daily functioning, causing disruption to daily activities, routines, and patterns. Multiple inter-related personal, social and environmental determinants influence the onset, nature and subsequent course of those difficulties. Research suggests a bi-directional relationship exists between mental health and activity choices. Activity-

Kapitlet ingår i en festskrift till professor emeritus Evert Vedung och har publicerats i Acta Universitatis Upsaliensis vid Uppsala universitet som ett av 25 kapitel i en forskarantlogi om utvärdering. I kapitlet återvänder jag till Vedungs rapport "Forskningens relevans, användbarhet, användning och nytta" från 1993. Det är en delrapport från ett treårigt FoU-projekt finansierat av Byggforskning