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The hemoprotein indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in mammalian tryptophan metabolism. It has received considerable attention in recent years, particularly due to its role in the pathogenesis of many diseases. Here, we report attempts to improve soluble expression and purification of hexahistidyl-tagged recombinant human IDO from Escherichia coli (EC538, pREP4,
GeoBIM, the integration of 3D geoinformation (Geo) with building information models (BIM), is a subject of increasing attention in both domains. A well-known practical challenge for this integration is the mixed state of software support for open standards in each domain that would ease the integration. This is often known by practitioners but poorly documented. In order to solve this problem, we
Transforming growth factor-α (TGF-α) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF- α in cytoplasmic granules. In monocytes, TGF-α did not colocalize with components of peroxidase-positive granules or with albumin of secretory vesicles. Furthermore, no colocal
This chapter examines the evolution of public support for the euro and public trust in the European Central Bank (ECB) during the new currency’s first two decades. Using a unique set of opinion poll data that is not available for any other currency, we find that a majority of citizens in every member country of the euro area (EA) support the euro. The economic crisis in the EA following the Great
BACKGROUND: Accurate classification of breast cancer using gene expression profiles has contributed to a better understanding of the biological mechanisms behind the disease and has paved the way for better prognostication and treatment prediction.RESULTS: We found that miRNA profiles largely recapitulate intrinsic subtypes. In the case of HER2-enriched tumors a small set of miRNAs including the H
If we ever decide to start geoengineering another world, and maybe even terraform a world that is not presently habitable for humans, it is also highly probable that it will become less habitable for any indigenous life. Making sure, or at least trying to determine the probability that a potentially habitable world is in fact uninhabited will thus be an important step before we start any geo-engin
Det finns en rad anledningar till varför ett allt intensivare brukande avjordbrukslandskapen i många industrialiserade länder, t.ex. i Europa, lett till att denbiologiska mångfalden minskat. Även om förlusten av mer eller mindre naturliga habitat är en viktig orsak till den minskade mångfalden, har den biologiskamångfalden påverkats starkt av intensivare odling på fälten. En viktig orsak till dett
Objectives: Double reading in diagnostic radiology can find discrepancies in the original report, but a systematic program of double reading is resource consuming. There are conflicting opinions on the value of double reading. The purpose of the current study was to perform a systematic review on the value of double reading. Methods: A systematic review was performed to find studies calculating th
BackgroundOrgan donation guidelines recommend a “clear” conventional bedside chest radiograph before lung transplantation despite only moderate accuracy for cardiopulmonary abnormalities.PurposeTo evaluate the influence of donor image interpretation on lung transplantation outcome in recipients by following early and late complications, one-year survival, and to correlate imaging findings and bloo
The IEEE Std. P1687.1 working group is currently exploring alternatives to IEEE Std. 1149.1 test access port (TAP) as the interface between the boundary of integrated circuits (ICs) and IEEE Std. 1687 networks. In this paper, we investigate the use of universal asynchronous receiver-transmitter (UART) to access IEEE Std. 1687 networks. We have developed a protocol to describe the information trans
