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Endoscopic versus Laparoscopic Full-Thickness Biopsy in the Pathological Evaluation of the Enteric Nervous System

A full-thickness biopsy of the bowel wall is required to evaluate the enteric nervous system. A patient with aggravating gastrointestinal symptoms underwent a laparoscopic full-thickness biopsy of the ileum and, 1 year later, an endoscopic full-thickness biopsy of the sigmoid colon. Both samples showed enteric neuropathy characterized by vacuolated and enlarged neurons. The length of the myenteric

Cone-beam computed tomography, a new low-dose three-dimensional imaging technique for assessment of bone erosions in rheumatoid arthritis : reliability assessment and comparison with conventional radiography – a BARFOT study

Objectives: To determine the intra- and inter-observer agreement of erosions detected and scored with cone-beam computed tomography (CBCT) of bones in the hands and feet, and to compare CBCT with conventional radiography (CR) for assessment of bone erosions in patients with long-standing rheumatoid arthritis (RA). Method: Thirty patients with long-standing RA from the Better Anti-Rheumatic Pharmac

De-pathologizing Perversion : Proust’s Sexual Discourses and Their Chinese Translations

The sexological aspects of Proust’s work have largely been neglected in its Chinese reception. The paper focuses on the Chinese (re)translations of Proust’s sexual discourses in À la recherche du temps perdu and expounds the epistemic challenges and the evolving strategies of translating sadomasochism and homosexuality into Chinese. It further explores how these observations refract the changing a

Scandinavia

The entry tells the history of Shakespeare in the Scandinavian countries from the late 18th century to 2014.

Evolution : An Irresistibly Clear View of Land

Visually guided predation is range-limited in water, but works over long distances on land. This may have driven our last aquatic ancestors to evolve large eyes on the top of their head for spotting crunchy meals on ancient riverbanks.

Precision medicine in obesity and type 2 diabetes : The relevance of early-life exposures

BACKGROUND: Type 2 diabetes is highly prevalent and devastating. Obesity is a diabetogenic factor, driving insulin resistance and a compensatory demand for increased insulin secretion from the pancreatic cells; a failure to address this demand results in diabetes. Accordingly, primary and secondary prevention of obesity are at the core of diabetes prevention programs. The development of obesity an

Automated computer-assisted quantitative analysis of intact murine lungs at the alveolar scale

Using state-of-the-art X-ray tomographic microscopy we can image lung tissue in three dimensions in intact animals down to a micrometer precision. The structural complexity and hierarchical branching scheme of the lung at this level of details, however, renders the extraction of biologically relevant quantities particularly challenging. We have developed a methodology for a detailed description of

C-H Activation Reactions Mediated by Pd Based Heterogeneous Catalysts : Regioselective Formation of C-O and C-X Bonds

Katalys är ryggraden i många processer i vardagen. Även människokroppen styrs huvudsakligen av katalysatorer. Detta viktiga koncept tillåter oss att på ett miljövänligt sätt konvertera råmaterial som råolja och naturgas till värdefulla och oersättliga produkter, till exempel motorbränslen, läkemedel och agrokemikalier. En katalysprocess drivs av en katalysator, vilket således är en substans som, uNew classes of N-heterocyclic carbene-palladium(II) complexes containing either a vinyl group in different positions or an anthracene tag in the backbone of the N-heterocycle were synthesized and fully characterized. The vinyl based complexes were copolymerized with divinylbenzene to fabricate robust polymer-supported NHC-Pd(II) systems, while the anthracene based complexes were π-stacked onto the

Helping Hand grasp rehabilitation : Preliminary assessment on chronic stroke patients

The Helping Hand (HH) system is a novel grasp rehabilitation platform aimed at simplifying the clinical usage of wearable electrode arrays for neuromuscular electrical stimulation (NMES). In a randomized dose-matched, clinical study we evaluate usability and effectiveness of the HH treatment, and of other enriched upper limb rehabilitation treatments, and compare the outcomes. This paper shows the

Optimization of land use pattern reduces surface runoff and sediment loss in a Hilly-Gully watershed at the Loess Plateau, China

Aim of study: The aim is to find a way increasing gain yield and lessen area of farmland, and then increasing vegetation cover, improving environment and alleviating soil erosion.Area of study: The Hilly-Gully region at the loess plateau of China.Material and methods: In this study, an adjusted and optimized land use pattern was developed in Luoyugou watershed in the Yellow River valley based on t

Experiences of living with increased risk of developing colorectal and gynaecological cancer in individuals with no identified gene mutation

Background: In most families with familial cancers, mutations have not been demonstrated; thus, healthy individuals cannot be tested for mutation status. As a consequence, many persons at risk of familial cancer live with an unknown, but presumably high, risk of developing cancer. Aim: The aim of this study was to describe individuals' perceptions of living with an increased risk of colorectal and

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer's disease mouse model 5xFAD

Alzheimer's disease (AD) is the most common form of dementia characterized by the formation of amyloid plaques (Aβ). Over the last decade, the important role of the innate immune system for the disease development has been established. Chronic activation of microglial cells creates a proinflammatory environment, which is believed to be central for the development of the disease as well as its prog

En dikt och ett misstag

En artikel om Ovidius Fasti, med anledning av Ingvar Björkesons översättning till svenska.

Emotive and sensory simulation through comparative construal

Using authentic textual data from written personal narratives, we investigate how individuals with Attention Deficit Hyperactivity Disorder (ADHD), Obsessive Compulsive Disorder (OCD) and Tourette Syndrome (TS) mediate their emotive and sensory experiences through language. Our study reveals that experiential comparisons of different kinds (Trying not to tic is like trying not to blink) feature pr

The prognostic role of cancer stem cell markers for long-term outcome after resection of colonic liver metastases

Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemis

Role of ZNF224 in c-Myc repression and imatinib responsiveness in chronic myeloid leukemia

The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription. Recently, we demonstrated that Bcr-Abl signaling represses ZNF224 expression in Bcr-Abl positive CML cell lines and in CML patients. Interestingly, Imatinib and second-generation tyrosine kinase inhibitors specifical