Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated lipid metabolism, proliferation is diminished. To study the outcome of CDK1 loss and blocked hepatocyte proliferation on lipid metabolism and the consequent impact on whole-body physiology, we performed lipidomics, metabolomics, and RNA-s

Background: In a previous study we interviewed significant others (SOs) directly following a patient's suicide attempt as a part of the psychiatric assessment. SOs added important information to the assessment and they needed professional counselling themselves. In the present study the opinions of SOs were investigated 1 year after a suicide attempt. Methods: Semi-structured interviews of 84 SOs

As part of the psychiatric assessment after a suicide attempt contact with a significant other could be of importance in order to obtain an additional view of the patient's situation, and thereby possibly broadening the basis of the assessment. The aims of this study were to investigate whether information from a significant other would be helpful in the psychiatric assessment of the patient, and

The aims of the present study were to investigate the existence of overconsumption of alcohol and tranquillizers in suicide attempters and whether overconsumers differ from those with no overconsumption. One hundred and twenty-six patients, evaluated and treated after a suicide attempt in a psychiatric ward, took part in a comprehensive investigation. This included questions on consumption of alco

During the last decades, a positive relation between a good alliance and a successful therapy outcome has been demonstrated across a variety of different therapeutic modalities. The relationship between alliance and drinking outcome in long-term treatment of alcoholics (12 months or more) has not, as far as we know, been presented. In the present study, alcoholics were randomized to two outpatient

Seventy-five patients were admitted to the ward of the Lund Suicide Research Center following a suicide attempt. After 5 years, the patients were followed up by a personal semistructured interview covering sociodemographic, psychosocial and psychiatric areas. Ten patients (13%) had committed suicide during the follow-up period, the majority within 2 years. They tended to be older at the index atte

The X-ray absorption spectrum of N2+ in the K-edge region has been measured by irradiation of ions stored in a cryogenic radio frequency ion trap with synchrotron radiation. We interpret the experimental results with the help of restricted active space multiconfiguration theory. Spectroscopic constants of the 1σu-1 ς2u+ state, and the two 1σu-13σg-11πg Π2u states are determined from the measuremen

Field measurement data on greenhouse gas (GHG) emissions are still scarce for many land-use types in Africa, causing a high level of uncertainty in GHG budgets. To address this gap, we present in situ measurements of carbon dioxide (CO2 ), nitrous oxide (N2 O), and methane (CH4) emissions from the lowlands of southern Kenya. We conducted eight chamber measurement campaigns on gas exchange from fou

The global climate transition from the Lateglacial to the Early Holocene is dominated by a rapid warming trend driven by an increase in orbital summer insolation over high northern latitudes and related feedbacks. The warming trend was interrupted by several abrupt shifts between colder (stadial) and warmer (interstadial) climate states following instabilities of the Atlantic Meridional Overturnin

50 years had passed since the introduction of the so-called safety bicycle when Kulturen's first yearbook was published in 1935. The bicycle was a common sight in everyday city life during the 1930s. Was it perhaps for this reason that it rarely featured in the yearbooks issued during the 1930s and 1940s? During these two decades it was most common to hear about them through adverts. Nonetheless t

With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleim

Microbial degradation of lignin and its related aromatic compounds has great potential for the sustainable production of chemicals and bioremediation of contaminated soils. We previously isolated Pseudomonas sp. strain 9.1 from historical waste deposits (forming so-called fiber banks) released from pulp and paper mills along the Baltic Sea coast. The strain accumulated vanillyl alcohol during grow

The predictors of the long‐term outcome in alcoholics (n= 50) who had been treated in a 2‐year outpatient treatment program were investigated. Previously, the sample had been followed up personally 2 years after the termination of treatment. This study is a repeated, independent follow‐up of the same sample over a 4‐year period, 3–6 years after termination of treatment. Outcome could be categorize

Objectives:We aimed to investigate possible associations between birth weight and adult life carotid-femoral pulse wave velocity (cfPWV) and augmentation pressure index (AIx).Design and method:This study included 1598 participants, that is, 340 elderly individuals from the Malmö Birth Data Cohort (MBDC) and 1258 young-middle aged individuals from the Malmö Offspring Study (MOS) with full data on b

Background: To increase the clinical usefulness of the D-dimer test in diagnosis of deep vein thrombosis (DVT), two strategies have been proposed: the age-adjusted, and the clinical pre-test probability (CPTP) adjusted interpretation. However, it is not known which of these strategies is superior. Objective: To conduct an individual patient data (IPD) meta-analysis that compares the sensitivity, s

The importance of previous suicidal behavior for the treatment of alcoholics was analyzed in a long‐term outpatient treatment study. In a series of 72 patients, 21 patients, (29%), 17 men and 4 women, had previously made at least one suicide attempt or had seriously threatened to kill themselves (3 cases). In comparison with the other alcoholics, those with previous suicidal behavior had a similar

I syfte att samla material kring vardagsliv, vanor och värderingar har Folklivsarkivet i Lund under lång tid skickat ut så kallade frågelistor. Varje lista utgår från ett särskilt ämne, svaren skrivs i löpande text och materialet används i forskning och för dokumentation. Men vad som anses intressant och relevant är inte detsamma idag som då den första listan sändes ut. Vilka ämnen som blir teman

Seventy-two alcoholic patients (60 men and 12 women) were randomized into four groups who received psychiatric treatment (PT) or multimodal behavioural therapy (MBT), for either 1 or 2 years. PT was based on psychodynamic principles, and MBT is a cognitive-behavioural treatment. The patients accepting treatment had a mean age of 37 ± 9 years, and they were socially stable. There was no difference