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Third cumulant for multivariate aggregate claim models

The third cumulant for the aggregated multivariate claims is considered. A formula is presented for the general case when the aggregating variable is independent of the multivariate claims. Two important special cases are considered. In the first one, multivariate skewed normal claims are considered and aggregated by a Poisson variable. The second case is dealing with multivariate asymmetric gener

Hyperparameter-free sparse regression of grouped variables

In this paper, we introduce a novel framework for semi-parametric estimation of an unknown number of signals, each parametrized by a group of components. Via a reformulation of the covariance fitting criteria, we formulate a convex optimization problem over a grid of candidate representations, promoting solutions with only a few active groups. Utilizing the covariance fitting allows for a hyperpar

Trace-based manycore partitioning of stream-processing applications

Application performance on these processor array platforms is highly sensitive to how functionality is physically placed on the device, as this choice crucially determines communication latencies and congestion patterns of the on-chip inter-core communication. The problem of identifying the best, or just a good enough, partitioning and placement does not, in general, admit to an analytic solution,

A targeted approach to maintenance of tumour response. Clinical and translational studies in metastatic colorectal cancer.

In metastatic colorectal cancer (mCRC) chemotherapy +/- targeted therapy with palliative intent aims at prolonging survival with sustained quality of life. Maintenance of tumour response by a period of less intense treatment maydelay progression and accumulation of unacceptable toxicity. We studied the combination of targeted treatment with the angiogenesis inhibiting antibody bevacizumab (bev) an

Det tidiga klosterväsendet och den antika bildningen. : Slutrapport från ett forskningsprogram

Denna rapport sammanfattar resultaten av forskningsprogrammet ”Det tidiga klosterväsendet och den antika bildningen”, som pågick åren 2009-2015. Rapporten är författad av programmets forskningsledare Samuel Rubenson, men bygger på det omfattande arbete som gjorts av programmets olika forskare: Elin Andersson, Anahit Avagyan, Jesper Blid Kullberg, Karin Kulneff-Eriksson, Britt Dahlman, Bo Holmberg,

Benchmarking of learning architectures for digital predistortion

Indirect and direct learning architectures are the two main parameter identification approaches for digital predistortion systems. While the indirect scheme is less complex, its inherent shortcomings are avoided by the direct learning approach. Trying to answer the question whether this advantage of the direct approach can be exploited in terms of measurable linearization-performance improvement i

High-level system synthesis and optimization of dataflow programs for MPSoCs

The growing complexity of digital signal processing applications make a compelling case the use of high-level design and synthesis methodologies for the implementation on reconfigurable and embedded devices. Past research has shown that raising the level of abstraction of design stages does not necessarily gives penalties in terms of performance or resources. Dataflow programs provide behavioral d

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr