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A Theoretical Investigation of the Magnetic-field-induced Transition in Fe X, of Importance for Measuring Magnetic Field Strengths in the Solar Corona

The use of the magnetic-field-induced transition (MIT) in Fe X for the measurement of the magnetic field strength in the solar corona has been discussed and demonstrated in a number of recent studies. This diagnostic technique depends on, among other conditions, the accuracy of the atomic data for Fe X. In the present work, we carry out a large-scale calculation for the atomic properties needed fo

A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression

Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of substrate function, substrate accumulation, or loss of a function(s) embodied in the substrate fragments. Hence, recapitulation of a protease-deficient phenotype b

Prospects for single-molecule electrostatic detection in molecular motor gliding motility assays

Molecular motor gliding motility assays based on myosin/actin or kinesin/microtubules are of interest for nanotechnology applications ranging from cargo-trafficking in lab-on-a-chip devices to novel biocomputation strategies. Prototype systems are typically monitored by expensive and bulky fluorescence microscopy systems. The development of integrated, direct electric detection of single filaments

A method-of-lines formulation for a model of reactive settling in tanks with varying cross-sectional area

Reactive settling denotes the process of sedimentation of small solid particles dispersed in a viscous fluid with simultaneous reactions between the components that constitute the solid and liquid phases. This process is of particular importance for the simulation and control of secondary settling tanks (SSTs) in water resource recovery facilities (WRRFs), formerly known as wastewater treatment pl

Mediational pathways from genetic risk to alcohol use disorder in swedish men and women

Objective: The purpose of this study was to clarify the mediational pathways from genetic risk for alcohol use disorder (AUD) to AUD itself. Method: Using information on AUD status from first-through fourth-degree relatives obtained from national registries, we created a genetic risk score for AUD for the Swedish population. We first tested a simple mediational path model in males and females sepa

Test automation with grad-CAM Heatmaps - A future pipe segment in MLOps for Vision AI?

Machine Learning (ML) is a fundamental part of modern perception systems. In the last decade, the performance of computer vision using trained deep neural networks has outperformed previous approaches based on careful feature engineering. However, the opaqueness of large ML models is a substantial impediment for critical applications such as in the automotive context. As a remedy, Gradient-weighte

High-frequency news sentiment and its application to forex market prediction

Financial news has been identified as an important alternative information source for modeling market dynamics in recent years. While most of the attention goes to stock markets, the foreign exchange (Forex) market, in contrast, is much less studied. Most of the existing text mining research for the Forex market combine news sentiment with other text features, making the contribution of each facto

3D X-Ray Diffraction Characterization of Grain Growth and Recrystallization in Rolled Braze Clad Aluminum Sheet

Braze clad on aluminum (Al) sheets has enabled fast and convenient brazing assembly of complex heat exchangers. However, there are details in the brazing process that are not fully understood. Herein, 3D X-ray diffraction (3DXRD) is used to investigate the grain position, size, and orientation before and after controlled atmosphere brazing (CAB). The outcomes are presented as maps of center-of-mas

Hearing impairment among children in Sweden with foreign-born parents and natives : A national Swedish study

Aim: We aimed to estimate the risk of hearing impairment in children and adolescents with foreign-born parents, compared to natives. Methods: A nationwide study of 1,923,590 (51.4% boys) individuals aged 0–17 years of age in Sweden. Hearing impairment was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2015. We used Cox regressio

Filled Julia Sets of Chebyshev Polynomials

We study the possible Hausdorff limits of the Julia sets and filled Julia sets of subsequences of the sequence of dual Chebyshev polynomials of a non-polar compact set K⊂ C and compare such limits to K. Moreover, we prove that the measures of maximal entropy for the sequence of dual Chebyshev polynomials of K converges weak* to the equilibrium measure on K.

Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation

Objectives: Total body irradiation (TBI) is commonly used prior to hematopoietic stem cell transplantation (HSCT) in myeloablative conditioning regimens. However, TBI may be replaced by total marrow irradiation (TMI) at centres with access to Helical TomoTherapy, a modality that has the advantage of delivering intensity-modulated radiotherapy to long targets such as the entire bone marrow compartm

Patients' experiences of well-being when being cared for in the intensive care unit—An integrative review

Objective: The aim of this integrative review was to identify facilitators and barriers to patients’ well-being when being cared for in an ICU setting, from the perspective of the patients. Background: To become critically ill and hospitalised in an ICU is a stressful, chaotic event due to the life-threatening condition itself, as well as therapeutic treatments and the environment. A growing body

Automated left atrial time-resolved segmentation in MRI long-axis cine images using active contours

Background: Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range of cardiovascular conditions, such as atrial fibrillation, stroke, and diastolic dysfunction. LA segmentations are currently being performed manually, which is time-consuming and observer-dependent. Methods: This study presents an automated imag

Demonstration: A cloud-control system equipped with intrusion detection and mitigation

The cloud control systems (CCs) are inseparable parts of industry 4.0. The cloud, by providing storage and computing resources, allows the controllers to evaluate complex problems that are too computationally demanding to perform locally. However, connecting physical systems to the cloud through the network can provide an entry point for attackers to infiltrate the system and cause damage with pot

Planning and governing nature-based solutions in river landscapes : Concepts, cases, and insights

Nature-based solutions (NBS), understood as actions that use ecosystem processes to address societal needs, can play important roles to future-proof river landscape development for people and nature. However, knowledge gaps exist how NBS can be planned and implemented at landscape scales. This Special Issue brings together insights and experiences from studies of assessing, planning, and implement

Genetics of quantitative traits with dominance under stabilizing and directional selection in partially selfing species

Recurrent self-fertilization is thought to lead to reduced adaptive potential by decreasing the genetic diversity of populations, thus leading selfing lineages down an evolutionary “blind alley.” Although well supported theoretically, empirical support for reduced adaptability in selfing species is limited. One limitation of classical theoretical models is that they assume pure additivity of the f

The Assassination of Fakhrizadeh—A Major Iranian Counterintelligence Failure?

The assassination of Iranian top nuclear scientist Mohsen Fakhrizadeh is one of numerous assassinations in Iran conducted by foreign powers ever since 2007. In the past six months, assassins have in addition to Fakhrizadeh also been able to kill Al-Qaida’s no. 2 on Iranian soil. The three most important organizations in the Iranian intelligence community are the Ministry of Intelligence, as well a

NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently, diphosphatase NUDT15 was linked to thiopurine metabolism with NUDT15 polymorphism associated with drug toxicity in patients. Profiling NNA drugs, we identify acyclovir (ACV) and ganciclovir (GCV) as two new NNAs metabo