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Self-propagating, amyloidogenic mutant huntingtin (mHTT) aggregates may drive progression of Huntington's disease (HD). Here, we report the development of a FRET-based mHTT aggregate seeding (FRASE) assay that enables the quantification of mHTT seeding activity (HSA) in complex biosamples from HD patients and disease models. Application of the FRASE assay revealed HSA in brain homogenates of presy

This thesis experimentally investigates the possibilities of using quantum effects in semiconductor nanostructures for engineering their thermoelectric properties. More specifically, heterostructured InAs/InP nanowires are used to create short InAs quantum dots (QDs) with electronic state structure resembling that found in atoms. Recently developed top-heater architecture is used to apply a temper

We predict bond betas conditioning on a number of macro-finance variables. We explore differences across long-term government bonds, investment grade corporate bonds, and high yield corporate bonds. We conduct out-of-sample forecasting using the new approach of combining predictor variables through complete subset regressions (CSR). We consider the robustness of CSR forecasts across the 1-month, 3

Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third D

Background: Treatment for cleft lip and/or palate (CL/P) involves a multidisciplinary team of experts who aim to improve ones’ appearance, health-related quality of life, and speech function. To appropriately measure outcomes in CL/P from the patient perspective, a CL/P-specific patient-reported outcome (PRO) instrument is needed. The CLEFT-Q is a self-report PRO instrument developed to evaluate t

Context. The second Gaia data release (Gaia DR2) contains high-precision positions, parallaxes, and proper motions for 1.3 billion sources as well as line-of-sight velocities for 7.2 million stars brighter than GRVS = 12 mag. Both samples provide a full sky coverage. Aims. To illustrate the potential of Gaia DR2, we provide a first look at the kinematics of the Milky Way disc, within a radius of s

Context. The Gaia spacecraft of the European Space Agency (ESA) has been securing observations of solar system objects (SSOs) since the beginning of its operations. Data Release 2 (DR2) contains the observations of a selected sample of 14,099 SSOs. These asteroids have been already identified and have been numbered by the Minor Planet Center repository. Positions are provided for each Gaia observa

Programmable logical controllers (PLCs) have been in use since the 1960s and are still the basis for the low-level control in many automation systems. Today PLCs can handle not only the lowest levels of control but also advanced control of hybrid systems, where time-driven continuous controllers have to be integrated with event-driven controllers. The state concept is of fundamental importance to

Sugars and starches belong to the category of carbohydrates, which are important energy sources for organisms and nonessential nutrients in the human diet. Sugars are mono- or disaccharides that can be immediately transformed to energy by organisms. Starches, on the other hand, are polysaccharides, a space-efficient storage of energy for organisms. Before transforming polysaccharides into energy f

The food industry, which is a major worldwide industry, is going through a revolution. Changing lifestyles and expectations, such as demand for fewer additives, have placed new demands on the industry, which can only be met by new technology. At the same time, the producers in this very large industry have a further challenge, namely, that of the countervailing power of the retailer. Some years ag

Engineering Aspects of Membrane Separation and Application in Food Processing presents an overview and introduction to a wide range of membrane processes, their unique characteristics and challenges. In the food industry, as in many industries, membranes have an environmental advantage over conventional processes that they displace, because they are less energy intensive. The processing at near-am

Measures of muscle mass, strength, and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX (fracture risk assessment tool) probability. In the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, United States), we investigated whether measures of physical performance/appendicular lean mass (ALM) by DXA pred

Vi har lyckan att leva i en föränderlig värld, och med förändringar följer variation. Den stora variationen i yttre egenskaper hos djur, och i synnerhet deras färger, fascinerar både forskare och lekmän. I den här avhandlingen utforskar jag flera aspekter på varför, och hur, färgvariation evolverar hos en karismatisk insektsgrupp. Dammflicksländor är färgglada, dagaktiva och visuellt drivna organiSexual conflict over mating shapes the interactions between males and females in many animals and is also responsible for dramatic adaptations in both sexes. In some species of pond damselflies (Odonata:Coeangrionidae), sexual conflict maintains discrete female-limited colour morphs over multiple generations and within populations. One of the female morphs is typically male-coloured and considered

The life expectancy of people with intellectual disabilities (ID) has steadily increased, which has been accompanied by an increased risk of dementia. Staff and managers are key resources for safety diagnosis since they deliver information about people with ID behavior every day. The aim of the present study was to explore the identification process employed by staff and managers to detect signs o

User attitudes on privacy with respect to location data has been extensively studied. However, user attitudes of privacy in relation to proximity sensing is still lacking. We present the results from a survey conducted on users of a proximity sensing application we developed and diffused by handing out phones with the proximity sensing application pre-installed, with 31 respondents. The results co