Glioma cells are characterized by their invasiveness and resistance against conventional therapeutics. Telomerase activity has been suggested to be an important target for glioma treatment. Here we assessed the anticancer effects and its potential mechanisms of lentiviral vector mediated siRNA knock-down of the human telomerase reverse transcriptase (hTERT) in U87MG human glioblastoma cells. Stabl

Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), In addition, it has been suggested that duodenal metallothionein (MT) may limit the transport of cadmium across the intestinal epitheli

Objective. Recently, it was reported that treatment with adrenocorticotrophic hormone (ACTH) has a strong lipid-lowering effect in healthy individuals. The mechanism behind this has not been established. The aim of the present investigation was to study the effect of ACTH on the plasma lipoprotein pattern in patients treated with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor. Design

The objectives of the present study were to estimate long-term risks of osteoporotic fractures. The incidence of hip, distal forearm, proximal humerus and vertebral fracture were obtained from patient records in Malmo, Sweden. Vertebral fractures were confined to those coming to clinical attention, either as an inpatient or an outpatient case. Patient records were examined to exclude individuals w

Because of conflicting evidence about several fundamental issues, long-distance animal navigation has yet to be satisfactorily explained. Among the unsolved problems are the nature of genetic spatial control of migration and the relationships between celestial and magnetic compass mechanisms and between different map-related cues in orientation and homing, respectively. In addition, navigation is

Annually laminated (varved) sediments from the River Angermanalven, mid-central Sweden, have been used to construct an annual 2000-year long record of varve thickness. Maximum daily annual discharge and mean varve thickness for the years 1909-1971 are significantly correlated (r = 0.87). A relationship between maximum daily annual discharge for the observed period (1909-1971) and varve thickness w

Virtual pedagogical agents (VPAs), i.e. computer generated characters in pedagogical roles, populate the digital society in increasing numbers. They are found in educational programs from preschool to university. In a broader educational context, they function as virtual medical counsellors, physical exercise coaches and guides on city web pages – and they also appear in edutainment and infotainme

How can an artificial island and a bridge-building project shape the dreams and plans for a transnational region? In this article I examine the making of the Oresund region of Denmark and Sweden by analyzing the intertwining of bridge construction and region building, from the early dreams and plans, to the actual construction phase, to the ceremonial opening in 2000, and to the difficult transiti

The IWA Anaerobic Digestion Model No. 1 (ADM1) was presented in 2002 and is expected to represent the state-of-the-art model within this field in the future. Due to its complexity the implementation of the model is not a simple task and several computational aspects need to be considered, in particular if the ADM1 is to be included in dynamic simulations of plant-wide or even integrated systems. I

Aims: Several studies have shown that self-rated health (SRH ) is associated with drug use. The aim of this study was to investigate the possible interaction between SRH and use of analgesics and hypnotics and its ability to predict disability pension. Methods: In 1974-78, complete birth-year cohorts of middle-aged male residents in Malmö, Sweden, were invited to a health screening, and the cohort

ABSTRACT: BACKGROUND: Traditional patterns relating to how to handle pregnancy and birth are often challenged due to migration. The purpose of this study was to describe Middle Eastern mothers' experiences of the maternal health care services in Sweden and the involvement of their male partner. METHODS: Thirteen immigrant mothers from the Middle East who had used the maternal health services in Sw

This paper describes a highly digitized direct conversion receiver of a single-chip quadruple-band RF transceiver that meets GSM/GPRS and EDGE requirements. The chip uses an advanced 0.25-mum BiCMOS technology. The I and Q on-chip fifth-order single-bit continuous-time sigma-delta (SigmaDelta) ADC has 84-dB dynamic range over a total bandwidth of +/-135 kHz for an active area of 0.4 mm(2). Hence,

This study was aimed to characterize the ability of human bone marrow mesenchymal stem cells (MSC) to differentiate into osteoblasts in vitro. Twenty-three women and 20 men at late adulthood (52-92 years of age) were selected for the study. MSCs were isolated and cultured in vitro and alkaline phosphatase (ALP) activity, secretion of amino-terminal propeptide of type I procollagen (PINP), type III

Home mechanical ventilation (HMV) is increasingly used as a therapeutic option to patients with symptomatic chronic hypoventilation. There is, however, a paucity of solid data on factors that could affect prognosis in patients on home ventilation. In the present study, our aim was to study several factors in these patients with potential influence on survival. We examined 1526 adult patients from