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Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration

The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed m

Experiences from early stages of a national industrial symbiosis programme in the UK: determinants and coordination challenges

This paper reviews the factors influencing the development and sustained operation of regional industrial symbiosis (IS) networks and discusses the roles a coordination body can play to alter these factors so as to catalyse the development and functioning of such networks. These are analysed within the context of experiences gained in the early stages of three regional IS programmes under developm

G proteins coupled to phospholipase C: molecular targets of long-term ethanol exposure

Long-term ethanol exposure is known to inhibit bradykinin-stimulated phosphoinositide hydrolysis in cultures of neuroblastoma x glioma 108-15 cells. In the present study, [3H]bradykinin binding, GTP-binding protein function, and phospholipase C activity were assayed in cells grown for 4 days in 100 mM ethanol with the aim of elucidating the molecular target of ethanol on signal transduction couple

Transverse and longitudinal Bose-Einstein correlations

We show how a difference in the correlation length longitudinally and transversely, with respect to the jet axis in e+e− annihilation, arises naturally in a model for Bose-Einstein correlations based on the Lund string model. In genuine three-particle correlations the difference is even more apparent and they provide therefore a good probe for the longitudinal stretching of the string field. The c

Beta-Cell-Targeted Expression of a Dominant-Negative Mutant of Hepatocyte Nuclear Factor-1{alpha} in Mice: Diabetes Model with {beta}-Cell Dysfunction Partially Rescued by Nonglucose Secretagogues.

We studied islet function in mice with beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor (HNF)-1alpha. At age 2-3 months, anesthetized transgenic and wild-type male mice underwent an intravenous glucose (1 g/kg) tolerance test (IVGTT). It was found that transgenic mice had an abolished insulin response in association with severe glucose intolerance. In other

The Jurassic-Cretaceous transition of Southern Sweden - palynological and sedimentological interpretation

Palynological studies on the Vitaback Clay help resolve the position of the Jurassic-Cretaceous boundary in southern Sweden. Well-preserved assemblages of terrestrial pollen and spores, together with abundant algae (Botrycoccus), and for the first time, dinoflagellates have been identified in the Vitaback Clay. A Berriasian age is corroborated for the Vitaback Clay based on the palynological data;

Relationship between vitamin use, smoking, and nausea and vomiting of pregnancy.

Background. Nausea and vomiting in pregnancy (NVP) is a common complaint but risk factors for NVP are not well characterized. Methods. Occurrence of NVP was studied by questionnaires given to pregnant women at their first visit to the antenatal care unit and were returned around gestational week 28. Results. Analysis of 3675 completed questionnaires was made. Nausea and vomiting in pregnancy was

The perfusion fraction in volunteers and in patients with ischaemic stroke

The fractional volume of capillary blood, i.e. the perfusion fraction f, was measured with the aid of an echo-planar imaging protocol originally designed for the measurement of water diffusion. In healthy volunteers, reasonable f values were obtained. In patients with cerebral ischaemic stroke, a marked decrease in the f value was seen in the infarcted region as compared with corresponding values

An evaluation of an optimal sampling strategy for meropenem in febrile neutropenics

Optimal sampling design with nonparametric population modeling offers the opportunity to determine pharma-cokinetic parameters for patients in whom blood sampling is restricted. This approach was compared to a standard individualized modeling method for meropenem pharmacokinetics in febrile neutropenic patients. The population modeling program, nonparametric approach of expectation maximization (N

Cerebral perfusion deficits in age-associated memory impairment. The role of tobacco smoking

Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Meth

The effect of short-duration sub-maximal cycling on balance in single-limb stance in patients with anterior cruciate ligament injury: a cross-sectional study

Background: It has previously been shown that an anterior cruciate ligament (ACL) injury may lead to impaired postural control, and that the ability to maintain postural control is decreased by fatigue in healthy subjects. To our knowledge, no studies have reported the effect of fatigue on postural control in subjects with ACL injury. This study was aimed at examining the effect of fatigue on bala

Perception of South Swedish Word Accents

A perceptual experiment concerning South Swedish word accents (accent I, accent II) is described. By means of editing and resynthesis techniques the F0 pattern of a test word in a phrase context has been systematically manipulated: initial rise (glide vs. jump) and final concatenation (6 timing degrees of the accentual fall). The results indicate that both a gliding rise and a late fall seem neces