Geometry projection-based topology optimization has attracted a great deal of attention because it enables the design of structures consisting of a combination of geometric primitives and simplifies the integration with computer-aided design (CAD) systems. While the approach has undergone substantial development under the assumption of linear theory, it remains to be developed for non-linear hyper

Purpose: Oligometastatic gastroesophageal cancer is a clinical entity with no standard treatment recommendation. Treatment with curative intent has recently emerged as an option for selected patients in contrast to the traditional palliative treatment strategy. This prospective study aimed to assess the safety and efficacy of combined systemic and local treatment with curative intent for patients

A new metaheuristic optimizer combined with artificial neural networks is proposed for streamflow prediction. Hence, the study aimed to forecast monthly streamflow of the main rivers in Urmia, Iran, by considering data shortage and using artificial neural network (ANN) models. By combining three variables: temperature, precipitation, and streamflow, we formulated five patterns, where 70% of the da

The utilization of industrial side streams for generating value has always been of interest, but in today's society, with a high focus on the circular economy, it is becoming increasingly important. Lime mud (whose major component is calcium carbonate, CaCO3) is a low-value by-product of the pulp and paper industry that is generated in considerable amounts during the causticizing process. Designin

Due to the large-scale production of lignin, continuous flow reactors are preferred for its further valorization through depolymerization. However, there is limited literature on their use in lignin depolymerization, especially concerning feedstock pretreatments and catalyst deactivation. Therefore, in this study, the impact of a batch solvolysis pretreatment on the mild reductive catalytic depoly

Mild reductive catalytic depolymerization (MRCD) of lignin offers a sustainable route to produce functionalized aromatic compounds. However, the economic viability is hindered by the need for expensive palladium (Pd) catalysts and the limited exploration of continuous flow reactors (CFRs), which are essential to achieve an adequate production scale. This study examines the impact of partial replac

Lignosulfonate, a macromolecular byproduct derived from the paper and pulp industry, is a promising feedstock for bioconversion processes due to its rich carbon content and widespread availability. We here present an approach for the production of muconic acid through the optimization of the oxidative depolymerization of lignosulfonate and its further conversion using a recombinant Pseudomona

Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b

This review examines the complex interaction between heavy metals and soil microorganisms, focusing on five common heavy metals (HM) (chromium -Cr-, copper -Cu-, nickel -Ni-, lead -Pb-, and zinc -Zn-) in polluted areas worldwide. The systematic review was performed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The literature selection procedure i

Cellulose and its derivatives are considered sustainable alternatives to non-biodegradable fossil-based plastics. Chemically modified cellulose fibres to dialcohol cellulose (DAC) fibres demonstrated a melt processing window between the glass transition and degradation temperatures which enabled their extrusion by using only water as a temporary plasticizer. With the aim of supporting an industria

Background: High-quality assessment of prostate MRI is fundamental in both clinical practice and screening. There is a lack of national level data on variability in prostate volume measurement and PI-RADS assessment. Methods of quality assurance need to be developed. Methods: All Swedish radiology departments were invited to participate in an external quality assurance of prostate MRI reading. Ten

In this study, laminar burning velocities (LBV) of ammonia in oxygen-enriched air (oxygen content ranging from 30 to 50 vol%) were investigated under various initial temperatures (298, 323, and 348 K) at a pressure of 1 atm, employing the heat flux method. Our measurements reveal substantial disparities with previously published data primarily obtained using the spherical flame method. The reliabi

Introduction: This study aims to evaluate the effects of a novel noise reduction software (INR, Canon Europe, Amsterdam, NL) on image quality (IQ) in Digital Radiography (DR) pelvic phantom images. Methods: In total, 53 pelvic phantom images and 360 technical images of a Contrast Detail Radiography phantom (CDRAD) were collected, including 8 different exposure levels (between 0.8 and 40 mAs at 70

Background: Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT. Objectives: This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive s

What were the effects of having a distinctively African American-sounding name on educational attainment, occupation, income, marital status, and longevity in early 20th century America? How did those effects differ for people based on their phenotypical race/ethnicity? The findings of contemporary research have shown racialized names to be related to negative outcomes such as job interview callba