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We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occur
The marine Quaternary of Vendsyssel has been studied in a series of new boreholes in the area, and the climatic development is discussed on the basis of foraminiferal assemblages and stable isotopes. The foraminiferal zones are correlated with previously published records from northern Denmark, and the spatial local and regional distribution is discussed in details based on the new evidence. The n
In this article we give the classification of compact exceptional simple Kantor triple systems defined on tensor products of composition algebras $A=\mathbb{A}_1\otimes\mathbb{A}_2$ such that their Kantor algebras ${\cal L}(\phi,A)$ are real forms of exceptional simple Lie algebras.
Chromosome banding as well as molecular cytogenetic methods are of great help in the diagnosis of mesenchymal tumors. Myoepithelial neoplasms of soft tissue including myoepitheliomas, mixed tumors, and parachordomas are diagnoses that have been increasingly recognized the last few years. It is still debated which neoplasms should be included in these morphologically heterogeneous entities, and the
We have analysed the mechanism of action for induction of apoptosis by N-substituted benzamides using declopramide as a lead compound. We show here that declopramide at doses above 250 microM in the mouse 70Z/3 pre-B cell line or in the human promyeolocytic cancer cell line HL60 induced cytochrome c release into the cytosol and caspase-9 activation. The broad spectrum caspase inhibitor zVADfmk and
Background Use of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy may represent a hazard for the foetus. In order to analyse this in an adequate way, knowledge of maternal characteristics as putative confounders is needed. Methods In the Swedish Medical Birth Register, 2149 pregnant women using BZDs or HBRAs were identified, 1944 of them in early pr
Objective. To analyze the Immoral immune response to Ro/SSA and La/SSB antigens in detail, in order to identify markers in mothers at high risk of having children with congenital heart block (CHB). Methods. Serum samples were obtained from 9 Ro/La-positive mothers who gave birth to affected children, from their 8 newborns with CHB, and from 26 Ro/La-positive mothers whose children were healthy. An
Prostaglandin (PG) E(2) (PGE(2)) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE(2) is accomplished by conversion of the cyclooxygenase (COX) product PGH(2) by several terminal prostaglandin E synthases (PGES). Among the known PGES isoforms, microsomal PGES type 1 (mPGES-1) and type 2 (mPGES-2) were found to be overexpressed in colorectal cancer (CRC); howe
BACKGROUND: Hepatoblastoma (HBT) is the most common hepatic neoplasm in children. This notwithstanding, little is known about pathogenetic factors, such as genetic abnormalities, of importance for the development and progression of this tumor type. To date, only 33 cytogenetically abnormal HBT have been published, and trisomies for chromosomes 2 and 20 have been shown to be the most frequent aberr
Humus samples were collected 12 growing seasons after the start of a simulated acid rain experiment situated in the subarctic environment. The acid rain was simulated with H2SO4, a combination of H2SO4 and HNO3, and HNO3 at two levels of moderate acidic loads close to the natural anthropogenic pollution levels of southern Scandinavia. The higher levels of acid applications resulted in acidificatio
Background Conflicting data have been published concerning the effect of calcium on binding of autoantibodies to tissue transglutaminase (tTG) in celiac disease (CD). Methods IgA-tTG and IgG-tTG were measured with radioligand binding assays (RBA) using human recombinant (hr) 35S-tTG produced in lysate of rabbit reticulocytes and with guinea pig (gp) tTG ELISA in 51 CD children (median: 5.7 years
Reducing energy use in buildings is essential to decrease the environmental impact. Outside Gothenburg in Sweden, 20 terrace houses were built according to the passive house standard and completed in 2001. The goal was to show that it is possible to build passive houses in a Scandinavian climate with very low energy use and to normal costs. The houses are the result of a project including research
A machine learning conceptual clustering method applied to reaction mechanisms provides an automatic and, hence, unbiased means to differentiate between reactive phases within a total reactive process. Similar reactive phases were defined by means of local reaction sensitivity values. The method was applied to the Hochgreb and Dryer aldehyde combustion mechanism of 36 reactions. Three major time r
A model, MAKEDEP, was developed for reconstructing historic atmospheric deposition and nutrient uptake for forests using present day values. Deposition is reconstructed by separation of wet deposition and throughfall into five different categories. Dry deposition is assumed to depend linearly on needle biomass. Non-marine deposition is scaled using general European emission and deposition trends f
The use of microspheres and nanospheres of poly(d,l-lactide-co-glycolide) (PLG) as a controlled-release drug delivery system has been the subject of great interest for at least two decades within the field of pharmaceuticals. Salts of zinc and other divalent cations are sometimes co-encapsulated in PLG particles to control the pH or to stabilize encapsulated proteins or peptides. Zinc salts are kn
