Background: Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. Methods: With the aim to develop effective cell replacement for HD, we assess

Athymic Nude Rat Brain Atlas will provide the first stereotaxic brain atlas of the athymic nude rat (Crl:NIH-Foxn1rnu), a T-cell deficient rat model commonly used in experimental studies and pre-clinical safety and efficacy studies. This 2D vector-based atlas contains coronal, sagittal, and horizontal brain sections of an athymic rat brain rendered from a single cleared specimen, placed in a compu

Two decades into the young history of e-participation research, we aim to take stock of the state of this field in the light of three developments that we argue have substantial implications for research on electronic participation:(1) dissolving boundaries between online and offline spheres of political participation;(2) academic isolation of e-participation research from other research fields re

The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have limited sensitivity until most dopaminergic neurons are lost. Here we show that cerebrospinal fluid levels of DOPA decarboxylase (DDC) (also known as aromatic L-amino acid decarboxylase) can accurately identify patients with Lewy body disease (LBD) (area under the curve (AUC) = 0.89; PFDR = 2.6 × 10-13) and

The Swedish Armed Forces (SwAF) air dive tables are under revision. Currently, the air dive table from the U.S. Navy (USN) Diving Manual (DM) Rev. 6 is used with an msw-to-fsw conversion. Since 2017, the USN has been diving according to USN DM rev. 7, which incorporates updated air dive tables derived from the Thalmann Exponential Linear Decompression Algorithm (EL-DCM) with VVAL79 parameters. The

The purpose of this study is to investigate the relationship between ownership concentration and corporate performance in Chinese listed companies. Enriching the theory of corporate governance. The empirical foundation consists of data collected from 1468 listed companies at the Shanghai and Shenzhen Stock Exchanges in China, spanning 2018 to 2022. We observed a statistically significant positive

This interview is part of a major research project that is based on interviews and discussions with influential decision-makers, facilitators, mediators and negotiators who were involved in Arab-Israeli peace negotiations over the past three decades, as well as on archival research in Oslo, London, Washington and Jerusalem. Semi-structured in-depth interviews were conducted with more than 80 Israe

The aim of this article is to explore the opportunities of using theoretical concepts as way of gaining a shared language for people participating in an active labour market program (ALMP). The investigated programme offered vocational education preparing for work in eldercare to unemployed individuals. Data was collected through interviews with ten participants and two teachers, and through obser

This thesis aimed at examining the effects of file and disk cache for certain writing patterns and file sizes for Beijer Electronic's human machine interface (HMI) panels with the focus on write amplification factor (WAF). The goal was to determine optimal configurations to reduce WAF for different use cases to prolong the lifetime of Beijer Electronic's HMI panels. A test application and

Sweden passed legislation to achieve a target of net zero greenhouse gas emissions by the end of 2045. The Energy Performance of Building Directive further obliged European countries to ensure zero-energy building codes and improve the quality of indoor environments when buildings are renovated, as approximately 40% of total greenhouse gas emissions in Sweden are produced while heating buildings.

Collateralized Loan Obligations (CLOs) are non-bank entities securitizing high-yield loans and trading these on secondary markets. They are decisive for the functioning of the leveraged loan market and therefore refinancing opportunities of firms. We assess how CLOs change their trading behavior when public attention to climate change rises. We find that CLOs increase exposure to high emission loa

Medical waste is produced in huge quantities daily, and the increasing amount of it is a worldwide issue that makes managing medical waste more and more crucial. Leakage or improper use of medical waste can be harmful, risking the environment and human lives. The pandemic COVID-19 has challenged current practices with the increasing number of waste and the possibility of transferring the virus fro

Food Traceability 4.0 refers to the application of fourth industrial revolution (or Industry 4.0) technologies to ensure food authenticity, safety, and high food quality. Growing interest in food traceability has led to the development of a wide range of chemical, biomolecular, isotopic, chromatographic, and spectroscopic methods with varied performance and success rates. This review will give an

En översikt över regleringen av apoteksväsendet i Danmark fram till 1600-talet och i Sverige fram till idag.

Purpose: This thesis aims to strengthen the understanding of contextual business model design within the last-mile delivery industry and create a foundation for transferable knowledge from which Swedish logistic service providers can draw knowledge connected to last-mile delivery business models from. Theoretical framework: The theoretical framework is a decision-making process model, illustratin

Purpose: The purpose of the study is to gain a deeper understanding of how MaaS business models can be designed and configured. Theoretical Perspective: The theoretical perspective is provided by a preliminary framework which consists of a synthesis between Business model theory and MaaS literature. Methodology: A qualitative single case study was employed with an abductive research approach. E

Purpose and research question: The purpose of this study is to investigate whether an improved ESG performance leads to a lower cost of debt, proxied by the yield spread of newly issued corporate bonds and if this effect is more pronounced for firms operating in a stronger institutional environment. We therefore ask the following two research questions: Does a higher ESG score lead to a lower cost