Astrocytes form functionally and morphologically distinct populations of cells with brain-region-specific properties. Human pluripotent stem cells (hPSCs) offer possibilities to generate astroglia for studies investigating mechanisms governing the emergence of astrocytic diversity. We established a method to generate human astrocytes from hPSCs with forebrain patterning and final specification wit

Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and cervical cancer, but its therapeutic benefit is limited by the development of resistance. Our previous studies demonstrated that BCAT1 promoted cell proliferation and decreased cisplatin sensitivity in HCC cells. However, the exact role and mechanism

Monte Carlo (MC) modelling techniques have been used extensively in Nuclear Medicine (NM). The theoretical energy resolution relationship (∝1/E−−√), does not accurately predict the gamma camera detector response across all energies. This study aimed to validate the accuracy of an energy resolution model for the SIMIND MC simulation code emulating the Siemens Symbia T16 dual-head gamma camera.Me

Sudden infant death syndrome (SIDS) is the unexpected death of an infant under one year of age that remains unexplained after a thorough investigation. Despite SIDS remaining a diagnosis of exclusion with an unexplained etiology, it is widely accepted that SIDS can be caused by environmental and/or biological factors, with multiple underlying candidate genes. However, the lack of biomarkers raises

The program HiggsSignals confronts the predictions of models with arbitrary Higgs sectors with the available Higgs signal rate and mass measurements, resulting in a likelihood estimate. A new version of the program, HiggsSignals-2, is presented that contains various improvements in its functionality and applicability. In particular, the new features comprise improvements in the theoretical input f

Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods:

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of p

Background: Dizziness and pain are common complaints that often appear concomitantly, with or without a causal relationship. However, these symptoms might maintain and exacerbate each other and other co-morbidities. Therefore, adequate rehabilitation may have to include an expanded focus on other deficits and preconditions, especially in older adults and in patients. Objective: To understand how f

Using data between 2003 and 2016, this paper assesses the degree and evolution of socio-economic inequalities in maternal health outcomes in four African countries. The study measures the trends of socio-economic inequalities in maternal healthcare and assesses the sources of socio-economic inequalities in maternal health through a decomposition approach. We find cross-country differences in the e

Objective: The aim of this study was to describe the change of antibiotic prescribing in pre-school children in the municipalities of the former Copenhagen County in Denmark and Skåne County in Sweden after 20 years of antibiotic stewardship effort. Furthermore, the variation in the prescribing of antibiotics between the municipalities and the correlation between municipal adult educational level

Aim of this deliverable is to describe the work being carried out for the conceptual design of the Open-Platform and Factsheets for GDSI, in accordance with the project plan of Simona Miraglia (Postdoc2-DTU-BYG) in collaboration with Carlos Moraleda Melero (Research assistant), Sebastian Thöns (DTU-BYG) and Peter Fantke (DTU-MAN). A brief literature review regarding basic terminology, key concepts

This report describes a system model for assessing and updating the condition state and reliability of bridge structures utilizing inspection and monitoring data. The system model was developed on the basis of an existing continuous single-cell prestressed concrete box girder. The system model consists of two integrated sub-models: a condition model for predicting the deterioration state of the bo

This report describes concepts for an intelligent bridge on the basis of a reliability-based condition assessment utilizing inspection and monitoring data. The central part of the concept is a model describing the bridge system. The overall bridge model is com-prised of deterioration models and a mechanical system model of the structure. The model is a-priori characterized by the input data (such