Control of haemorrhage is vital in all operative settings. As complement to traditional surgical haemostatic techniques, a heterogeneous collection of absorbable substances with haemostatic capacity have been developed; topical haemostatic agents. The widespread variety of the products and the study-populations (clinical or experimental) make interpretation of previously performed studies difficul

Aims Delcasertib is a selective inhibitor of delta-protein kinase C (delta-PKC), which reduced infarct size during ischaemia/reperfusion in animal models and diminished myocardial necrosis and improved reperfusion in a pilot study during primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI). Methods and results A multicentre, double-blind trial was perform

In this article, we analyse the evolution and transformation of Danish spatial planning from its tentative origins in liberalist politics, through its rise as a central feature of the welfare state project, to its more recent entrepreneurial forms in a context of neoliberalisation. The article demonstrates how transformations of Danish spatial planning discourses and practices must be understood i

Integrated Water Resources Management (IWRM) is a relatively new approach in Bolivia. However, it is now generally accepted that this approach needs to be established in order to find sustainable solutions for development and is actively promoted by the Water Ministry, especially in environmentally fragile regions, such as the Lake Poopo basin. The Lake Poopo basin is one of the poorest regions in

Ultraviolet radiation (UVR) causes physical damage to DNA, carboxylation of proteins and peroxidation of lipids in copepod crustaceans, ubiquitous and abundant secondary producers in most aquatic ecosystems. Copepod adaptations for long duration exposures include changes in behaviour, changes in pigmentation and ultimately changes in morphology. Adaptations to short-term exposures are little studi

The far-infrared spectra of solid orthodeuterium and solid normal deuterium are presented and compared to the corresponding spectra of solid parahydrogen and solid normal hydrogen. Spectra of water in orthodeuterium are compared to spectra of water in parahydrogen. The water rotation constants in orthodeuterium are approximately 80% of the rotation constants of water in parahydrogen. The S(0)(0) b

Objective: To evaluate the ability of a postnatal weight-gain algorithm (WINROP) to identify sight-threatening retinopathy of prematurity (ROP type 1) in a nation-based extremely preterm infant cohort. Methods: This study enrolled all 707 live-born extremely preterm (gestational age [GA]

Vartannat år anordnar Nordisk Lichenologisk Förening en exkursion, vanligen till något av medlemsländerna. 2013 var det Sveriges tur att vara värdland. Den första exkursionen gick till Saxnäs i Lappland och nu den 20e till Vadstena. Läs denna ingående rapport från arrangemanget.

Background: ADAMTS13 is the physiological von Willebrand factor (VWF)-cleaving protease. The aim of this study was to examine ADAMTS13 expression in kidneys from ADAMTS13 wild-type (Adamts13(+/+)) and deficient (Adamts13(-/-)) mice and to investigate the expression pattern and bioactivity in human glomerular endothelial cells. Methodology/Principal Findings: Immunohistochemistry was performed on k

Measurements of cross sections of inelastic and diffractive processes in proton-proton collisions at LHC energies were carried out with the ALICE detector. The fractions of diffractive processes in inelastic collisions were determined from a study of gaps in charged particle pseudorapidity distributions: for single diffraction (diffractive mass M-X < 200 GeV/c(2)) sigma(SD)/sigma(INEL) = 0.21 +/-

Background: Estimations of the risk of bisphosphonate associated atypical femoral fractures vary between different population-based studies, from considerable to neglectable. A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use. Methods: In a previo

Popular Abstract in Swedish Bröstcancer är den vanligaste maligna sjukdomen hos kvinnor i världen. Årligen insjuknar mer än 7300 kvinnor i Sverige, vilket innebär nästan 30 % av all kvinnlig cancer. Mer än 80 000 kvinnor i Sverige är friska efter att ha blivit behandlade för bröstcancer, och cirka 3000 kvinnor lever med återfall av sjukdomen. Prognosen har förbättrats de senaste decennierna, delviRadiotherapy (RT) after mastectomy has been part of the treatment for early breast cancer since the 1940s. The treatment reduces the risk of loco-regional recurrences, but implies risk of late side effects that can begin decades after RT. Aims of the thesis were: - To analyse the long term effects of postmastectomy radiotherapy and systemic treatment for 1100 stage II breast cancer patients in t

The addition of amphiphiles grafted with polyethylene glycol units to constructs of DNA-amphiphiles is of most relevance for applications demanding colloidal stability. In this work, we study the self-assembly behavior of a true ternary mixture comprising (i) an electroneutral complex of DNA and a cationic surfactant (dodecyltrimethylammonium, DTA), (ii) water, and (iii) nonionic surfactant (dodec

Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS. In the present study, we hypothesized that Rac1 signaling might regulate M1 protein-induced lung injury. We studied the effect of a Rac1 inhibitor (NSC23766) o

Background. Poor ultrafiltration is associated with worse outcomes in peritoneal dialysis (PD) patients. This might in part reflect problems associated with salt and water excess. Increasing the diffusive component of peritoneal sodium removal using low-sodium PD fluids might have beneficial effects on blood pressure (BP), thirst and fluid status that could translate into clinical benefits. Method

Background Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have a high risk of developing colorectal cancer and dysplasia. Ursodeoxycholic acid (UDCA) has been suggested to have chemopreventive effects on the development of colorectal cancer and dysplasia but long-term data and larger trials are lacking. Aim To evaluate the effect of high dose (17-23 mg/kg/d