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Breast cancer, a common and often aggressive malignancy, presents significant challenges due to its ability to develop resistance to therapies. This resistance is intricately linked to the function and regulation of the estrogen receptor, a key driver of breast cancer cell proliferation. Our research focuses on unraveling the complex mechanisms underlying this resistance by investigating the roles
The collection contains hitherto unpublished poems from the period 2017 - 2020
The risk of sports participation in elite athletes with cardiac disease with an indication for implantable cardioverter-defibrillator (ICD) therapy is largely unknown. Currently, international guidelines provide restrictive sports advice for such athletes. This case report presents a professional football player who after an episode of syncope and diagnosis of apical hypertrophic cardiomyopathy ex
Bokverkets första del behandlar tiden från istidens slut ca 10000 år före vår tideräkning fram till 1658 då Blekinge blev svenskt. I del 1 behandlas stenålderns och metalltidernas kontakter, mobilitet, gravskick, boplatser, näringsförhållanden. Profana och religiösa maktförhållanden analyseras liksom bebyggelse, kultur- och naturförhållanden. Handeln belyses via vattenvägarna, de tidiga städerna,
Avfallshantering i historisk tid, i nutid och i framtiden.
Cellular communication within the brain is imperative for maintaining homeostasis and mounting effective responses to pathological triggers like hypoxia. However, a comprehensive understanding of the precise composition and dynamic release of secreted molecules has remained elusive, confined primarily to investigations using isolated monocultures. To overcome these limitations, we utilized the pot
Although very few people appear to travel to the Nordic region in contexts that might accurately be described as ‘climate-related,' some Nordic states have developed bespoke legal provisions, and all have ‘exceptional grounds’ categories that may be applied when people seek to enter or remain in the context of climate change or disaster. This chapter provides a brief overview of legal provisions r
The anesthetic drug propofol is commonly used to control hypnotic depth (suppression of awareness) in patients undergoing surgery or intensive care. In addition to manual titration, a model-based open-loop feed-forward strategy called target-controlled infusion (TCI) has attained some clinical popularity. Research on closed-loop control, with awareness estimates derived from an electroencephalogra
The global COVID-19 pandemic fundamentally changed education as we know it. Globally, billions of learners at all levels were affected by months of rolling school closures and other severe pandemic restrictions to daily life. Magnifying issues of educational equity, access, and opportunity, this unprecedented global crisis forced Deans, and academic and professional staff in schools of education tThe global COVID-19 pandemic fundamentally changed education as we know it. Globally, billions of learners at all levels were affected by months of rolling school closures and other severe pandemic restrictions to daily life. Magnifying issues of educational equity, access, and opportunity, this unprecedented global crisis forced Deans, and academic and professional staff in schools of education t
Reliance on corporate and financial non-state actors in the context of migration has accelerated over the last three decades. The involvement of these actors can, under certain circumstances, bring advantages in terms of providing rapid and reliable access to private funds and professional services. It can, however, also pose crucial challenges in terms of ascertaining legal responsibility when su
Knowledge seems to mitigate the consequences of dementia and new educational strategies are required. This study aimed to qualitatively explore the reflexive views and experiences of virtual Communities of Practice (vCoP) among informal and formal caregivers of people with dementia and explore vCoP as a tool for learning and knowledge development. Data were collected in a sequence of virtual works
Phenotypic plasticity can be adaptive in fluctuating environments by providing rapid environment-phenotype matching and this applies particularly in seasonal environments. African Bicyclus butterflies have repeatedly colonized seasonal savannahs from ancestral forests around the late Miocene, and many species now exhibit seasonal polyphenism. On a macroevolutionary scale, it can be expected that s
We report on the synthesis and detailed spectroscopic characterization of bis-phenylhydrazone astaxanthin (BPH-Asx), a derivative of astaxanthin (Asx), in which the conjugated carbonyl group of Asx is replaced by a conjugated C N bond. BPH-Asx was successfully synthesized and characterized using various spectroscopic techniques, revealing subtle changes in absorption spectra and significant altera
A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.
