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S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation end-products (RAGE) interacts with both S100A9 and S100A4. Furthermore, we show that S100A9 and S100A4 interact with RAGE and TLR4; interac
Measurements based on a large number of red giant stars suggest a broad metallicity distribution function (MDF) for the Galactic bulge, centered on [Fe/H] approximate to -0.1. However, recently, a new opportunity emerged to utilize temporary flux amplification (by factors of similar to 100 or more) of faint dwarf stars in the Bulge which are gravitationally lensed, making them observable with high
Migration has evolved as a strategy to maximise individual fitness in response to seasonally changing ecological and environmental conditions. However, migration can also incur costs, and quantifying these costs can provide important clues to the ultimate ecological forces that underpin migratory behaviour. A key emerging model to explain migration in many systems posits that migration is driven b
To fully exploit the environmental benefits of the biogas process, the digestate should be recycled as biofertiliser to agriculture. This practice can however be jeopardized by the presence of unwanted compounds such as heavy metals in the digestate. By using two-stage digestion, where the first stage includes hydrolysis/acidification and liquefaction of the substrate, heavy metals can be transfer
Abstract is not available
The objective of this study was to evaluate the effect of alpha-ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of alpha-ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 i
The aim of this study was to evaluate how the fixed furniture dimensions match with students' anthropometry and to describe head, upper back and upper limbs postures and movements. Evaluation was performed in 48 students from a Brazilian state school. Furniture dimensions were measured with metric tape, movements and postures by inclinometers (Logger Tecknologi, Akarp, Sweden). Seat height was hig
Popular Abstract in Swedish Det har diskuterats huruvida mäns spermiekoncentration minskat och missbildningar i pojkars könsorgan ökat under den senare delen av 1900-talet. Med säkerhet har dock testikelcancer ökat flerfaldigt under samma tidsperiod. Målet med denna avhandling var dels att undersöka huruvida skånska mäns spermakvalitet hade förändrats under det förra årtiondet, dels att studera saA decrease in male reproductive function, including sperm counts, during the second half of the 20th century, has been postulated. During this period, testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative trend in male reproductive function. One important lifestyle factor is smoking. However, smoking dur
The aim of this study was to explore the variation and regulation of bacterial carbon processing at a coastal oligotrophic site of the Island of Majorca in the Mediterranean Sea. In situ bacterial production (BP), respiration (BR), growth efficiency, and carbon demand in relation to environmental parameters were studied over an annual cycle. In addition, the response of bacterial carbon processing
Popular Abstract in Swedish Det talas mycket om rättvis fred i den allmänna debatten men det är ett ämne som är lite utforskat av akademiker. Det vetenskapliga pusslet som ligger till grund för denna avhandling är att undersöka vad en rättvis fred är, dels konceptuellt i fredsbyggande mer generellt, och empiriskt i förhållande till EU och den israelisk-palestinska konflikten. EU har använt termeJust peace has been much talked about in everyday life, but it is less well researched by academics. The puzzle underlying this dissertation is therefore to probe what constitutes a just peace, both conceptually within the field of peacebuilding and empirically in the context of the EU as a peacebuilder in the Israeli-Palestinian conflict. The EU has used the term just peace in many of its most
Oestrogens are important sex hormones central to health and disease in both genders that have protective effects on the cardiovascular and metabolic systems. These hormones act in complex ways via both genomic and non-genomic mechanisms. The genomic mechanisms are relatively well characterized, whereas the non-genomic ones are only beginning to be explored. Two oestrogen receptors (ER), ER alpha a
Physicians caring for the critically ill are now expected to acquire competence in echocardiography. It has become an indispensable diagnostic and monitoring tool in acute care settings where it is generally accepted to have therapeutic impact. There are a number of indications for a critical care echocardiographic study, and the most important queries include those pertaining left and right ventr
Background: In workplace health promotion, all potential resources needs to be taken into consideration, not only factors relating to the absence of injury and the physical health of the workers, but also psychological aspects. A dynamic balance between the resources of the individual employees and the demands of work is an important prerequisite. In the home care services, there is a noticeable t
This article analyses three recent and very successful Scandinavian films – Niels Arden Oplev’s Män som hatar kvinnor/The Girl with the Dragon Tatoo (Sweden), Susanne Bier’s Hævnen/In a Better World (Denmark) and Sara Johnsen’s Upperdog (Norway) – in order to understand how the relationship between the national and the international is articulated. Focus is on the scenes taking place abroad and on
