Aims: Huntington disease (HD) is a fatal neurodegenerative disorder with no disease-modifying treatments approved so far. Ongoing clinical trials are attempting to reduce huntingtin (HTT) expression in the central nervous system (CNS) using different strategies. Yet, the distribution and timing of HTT-lowering therapies required for a beneficial clinical effect is less clear. Here, we investigated

Lately have the demands on good room acoustics in public ordinary rooms increased. Traditionally has only reverberation time been considered in this type of rooms but complementary parameters as sound strength and speech clarity are more commonly used today. This trend naturally implies higher demands on the acoustic treatment. Typical for public ordinary rooms is to use an absorbent ceiling. One

Rapport som sammanfattar utvärderingen av den första generationen av tematiska samverkansinitiativ vid Lunds universitet 2017-2019.

This article connects to the discussion on skills and knowledge during the early industrialisation. It focuses on how two out of four technical secondary schools in Sweden (Malmö and Borås) lived up to their aims communicated by politicians and other stakeholders: to provide emerging industries and crafts in their regions with technicians and to prepare for studies at the Technological Institute.

Historical commons represent self-governed governance regimes that regulate the use and management of natural and man-made shared resources. Despite growing scientific interests, analyses of commons evolution and temporal dynamics are rare and drivers of change (birth, adaptation, dissolution) remain obscure. We apply an interdisciplinary approach and address these issues from an eco-evolutionary

Studien kartlägger litteraturämnen i kandidatuppsatser och avhandlingar i romanska språk i Sverige under tidsperioden 2000-2016. Syftet är att belysa olika litteraturers roll och (o)synliggörande i självständiga arbeten. Ansatsen är deskriptiv och ämnar identifiera mönster och tendenser i materialet. Dessa mönster ska ligga till grund för fördjupade studier av områden med utvecklingspotential i de

BACKGROUND: Preterm infants are susceptible to hyperglycemia and hypoglycemia, conditions which may lead to adverse neurodevelopment. The use of continuous glucose monitoring devices (CGM) might help keeping glucose levels in the normal range, and reduce the need for blood sampling. However, the use of CGM might be associated with harms in the preterm infant. OBJECTIVES: Objective one: to assess t

In all planning processes, including those we label participatory, there are neglected parties. Even when co-produced decisions, equity objectives, or common initiatives are at hand, some actors are likely to be less listened to, or they are never even recognised, hence, ‘perfect’ participation does not exist. Nevertheless, participatory objectives continue to be an important resilience factor in

By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values

Case isolation is a strategy with the potential to curb infectious disease epidemics. Expressions for the stability boundary of a case isolation scheme defined through the proportion of the infectious population that it isolates with a given delay have recently been established. Here we quantify how this stability boundary moves when heterogeneity of the inter-individual contact network increases,

In order to convince both policy makers and the general public to engage in climate change mitigation activities, it is crucial to communicate the inherent risks in an effective way. Due to the complexity of the system, mitigation activities cannot completely rule out the possibility of the climate reaching a dangerous tipping point but can only reduce it to some unavoidable residual risk level. W

In the present paper, computational auralizations of a single pass-by of a passenger car and passenger train are investigated. Auralization of future traffic noise scenarios would be a valuable tool for city planners, noise consultants and decision makers, since it would make it possible to evaluate various noise mitigation solutions already at the planning stage. The main goal of the Swedish mult

Non-invasive imaging biomarkers (IBs) are warranted to enable improved diagnostics and follow-up monitoring of interstitial lung disease (ILD) including drug-induced ILD (DIILD). Of special interest are IB, which can characterize and differentiate acute inflammation from fibrosis. The aim of the present study was to evaluate a PET-tracer specific for Collagen-I, combined with multi-echo MRI, in a

I arbetet har på uppdrag av en myndighet genomförts en genomlysning av ett på myndigheten internt utbildningsunderlag, i syfte att på vetenskaplig grund kvalitetssäkra utbildningen.